<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:e14f370b-ae1a-4971-9d24-dce0163a0dde,g:80025aa3-f607-4952-8539-bd3df5600574-->
<xs:schema xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:tars="http://tarsusrx.com/20251231" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2024-01-31" attributeFormDefault="unqualified" elementFormDefault="qualified" targetNamespace="http://tarsusrx.com/20251231">
  <xs:import namespace="http://fasb.org/srt/2025" schemaLocation="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd"/>
  <xs:import namespace="http://fasb.org/us-gaap/2025" schemaLocation="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/2024-01-31" schemaLocation="https://www.xbrl.org/dtr/type/2024-01-31/types.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/cyd-af-sub/2025" schemaLocation="https://xbrl.sec.gov/cyd/2025/cyd-af-sub-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei/2025" schemaLocation="https://xbrl.sec.gov/dei/2025/dei-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/ecd/2025" schemaLocation="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd"/>
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="tars-20251231_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="tars-20251231_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="tars-20251231_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="tars-20251231_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:type="simple"/>
      <link:roleType id="Cover" roleURI="http://tarsusrx.com/role/Cover">
        <link:definition>0000001 - Document - Cover</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="AuditInformation" roleURI="http://tarsusrx.com/role/AuditInformation">
        <link:definition>0000002 - Document - Audit Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BALANCESHEETS" roleURI="http://tarsusrx.com/role/BALANCESHEETS">
        <link:definition>9952151 - Statement - BALANCE SHEETS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BALANCESHEETSParenthetical" roleURI="http://tarsusrx.com/role/BALANCESHEETSParenthetical">
        <link:definition>9952152 - Statement - BALANCE SHEETS (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STATEMENTSOFOPERATIONSANDCOMPREHENSIVELOSS" roleURI="http://tarsusrx.com/role/STATEMENTSOFOPERATIONSANDCOMPREHENSIVELOSS">
        <link:definition>9952153 - Statement - STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STATEMENTSOFSTOCKHOLDERSEQUITY" roleURI="http://tarsusrx.com/role/STATEMENTSOFSTOCKHOLDERSEQUITY">
        <link:definition>9952154 - Statement - STATEMENTS OF STOCKHOLDERS&#8217; EQUITY</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STATEMENTSOFSTOCKHOLDERSEQUITYParenthetical" roleURI="http://tarsusrx.com/role/STATEMENTSOFSTOCKHOLDERSEQUITYParenthetical">
        <link:definition>9952155 - Statement - STATEMENTS OF STOCKHOLDERS&#8217; EQUITY (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STATEMENTSOFCASHFLOWS" roleURI="http://tarsusrx.com/role/STATEMENTSOFCASHFLOWS">
        <link:definition>9952156 - Statement - STATEMENTS OF CASH FLOWS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DESCRIPTIONOFBUSINESSANDPRESENTATIONOFFINANCIALSTATEMENTS" roleURI="http://tarsusrx.com/role/DESCRIPTIONOFBUSINESSANDPRESENTATIONOFFINANCIALSTATEMENTS">
        <link:definition>9952157 - Disclosure - DESCRIPTION OF BUSINESS AND PRESENTATION OF FINANCIAL STATEMENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESANDUSEOFESTIMATES" roleURI="http://tarsusrx.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESANDUSEOFESTIMATES">
        <link:definition>9952158 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES AND USE OF ESTIMATES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTS" roleURI="http://tarsusrx.com/role/FAIRVALUEMEASUREMENTS">
        <link:definition>9952159 - Disclosure - FAIR VALUE MEASUREMENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BALANCESHEETACCOUNTDETAIL" roleURI="http://tarsusrx.com/role/BALANCESHEETACCOUNTDETAIL">
        <link:definition>9952160 - Disclosure - BALANCE SHEET ACCOUNT DETAIL</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STOCKHOLDERSEQUITY" roleURI="http://tarsusrx.com/role/STOCKHOLDERSEQUITY">
        <link:definition>9952161 - Disclosure - STOCKHOLDERS&#8217; EQUITY</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STOCKBASEDCOMPENSATION" roleURI="http://tarsusrx.com/role/STOCKBASEDCOMPENSATION">
        <link:definition>9952162 - Disclosure - STOCK-BASED COMPENSATION</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NETLOSSPERSHARE" roleURI="http://tarsusrx.com/role/NETLOSSPERSHARE">
        <link:definition>9952163 - Disclosure - NET LOSS PER SHARE</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SEGMENTREPORTING" roleURI="http://tarsusrx.com/role/SEGMENTREPORTING">
        <link:definition>9952164 - Disclosure - SEGMENT REPORTING</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSCONTINGENCIES" roleURI="http://tarsusrx.com/role/COMMITMENTSCONTINGENCIES">
        <link:definition>9952165 - Disclosure - COMMITMENTS&#160;&amp; CONTINGENCIES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OUTLICENSEAGREEMENTS" roleURI="http://tarsusrx.com/role/OUTLICENSEAGREEMENTS">
        <link:definition>9952166 - Disclosure - OUT-LICENSE AGREEMENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CREDITFACILITYAGREEMENTS" roleURI="http://tarsusrx.com/role/CREDITFACILITYAGREEMENTS">
        <link:definition>9952167 - Disclosure - CREDIT FACILITY AGREEMENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXES" roleURI="http://tarsusrx.com/role/INCOMETAXES">
        <link:definition>9952168 - Disclosure - INCOME TAXES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RELATEDPARTYTRANSACTIONS" roleURI="http://tarsusrx.com/role/RELATEDPARTYTRANSACTIONS">
        <link:definition>9952169 - Disclosure - RELATED PARTY TRANSACTIONS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EMPLOYEEBENEFITPLAN" roleURI="http://tarsusrx.com/role/EMPLOYEEBENEFITPLAN">
        <link:definition>9952170 - Disclosure - EMPLOYEE BENEFIT PLAN</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SUBSEQUENTEVENT" roleURI="http://tarsusrx.com/role/SUBSEQUENTEVENT">
        <link:definition>9952171 - Disclosure - SUBSEQUENT EVENT</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESANDUSEOFESTIMATESPolicies" roleURI="http://tarsusrx.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESANDUSEOFESTIMATESPolicies">
        <link:definition>9955511 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES AND USE OF ESTIMATES (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESANDUSEOFESTIMATESTables" roleURI="http://tarsusrx.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESANDUSEOFESTIMATESTables">
        <link:definition>9955512 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES AND USE OF ESTIMATES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSTables" roleURI="http://tarsusrx.com/role/FAIRVALUEMEASUREMENTSTables">
        <link:definition>9955513 - Disclosure - FAIR VALUE MEASUREMENTS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BALANCESHEETACCOUNTDETAILTables" roleURI="http://tarsusrx.com/role/BALANCESHEETACCOUNTDETAILTables">
        <link:definition>9955514 - Disclosure - BALANCE SHEET ACCOUNT DETAIL (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STOCKHOLDERSEQUITYTables" roleURI="http://tarsusrx.com/role/STOCKHOLDERSEQUITYTables">
        <link:definition>9955515 - Disclosure - STOCKHOLDERS&#8217; EQUITY (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STOCKBASEDCOMPENSATIONTables" roleURI="http://tarsusrx.com/role/STOCKBASEDCOMPENSATIONTables">
        <link:definition>9955516 - Disclosure - STOCK-BASED COMPENSATION (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NETLOSSPERSHARETables" roleURI="http://tarsusrx.com/role/NETLOSSPERSHARETables">
        <link:definition>9955517 - Disclosure - NET LOSS PER SHARE (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SEGMENTREPORTINGTables" roleURI="http://tarsusrx.com/role/SEGMENTREPORTINGTables">
        <link:definition>9955518 - Disclosure - SEGMENT REPORTING (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSCONTINGENCIESTables" roleURI="http://tarsusrx.com/role/COMMITMENTSCONTINGENCIESTables">
        <link:definition>9955519 - Disclosure - COMMITMENTS&#160;&amp; CONTINGENCIES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CREDITFACILITYAGREEMENTSTables" roleURI="http://tarsusrx.com/role/CREDITFACILITYAGREEMENTSTables">
        <link:definition>9955520 - Disclosure - CREDIT FACILITY AGREEMENTS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESTables" roleURI="http://tarsusrx.com/role/INCOMETAXESTables">
        <link:definition>9955521 - Disclosure - INCOME TAXES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DESCRIPTIONOFBUSINESSANDPRESENTATIONOFFINANCIALSTATEMENTSDetails" roleURI="http://tarsusrx.com/role/DESCRIPTIONOFBUSINESSANDPRESENTATIONOFFINANCIALSTATEMENTSDetails">
        <link:definition>9955522 - Disclosure - DESCRIPTION OF BUSINESS AND PRESENTATION OF FINANCIAL STATEMENTS (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESANDUSEOFESTIMATESAdditionalInformationDetails" roleURI="http://tarsusrx.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESANDUSEOFESTIMATESAdditionalInformationDetails">
        <link:definition>9955523 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES AND USE OF ESTIMATES - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESANDUSEOFESTIMATESGrossProductSalesandAccountsReceivableNetDetails" roleURI="http://tarsusrx.com/role/SUMMARYOFSIGNIFICANTACCOUNTINGPOLICIESANDUSEOFESTIMATESGrossProductSalesandAccountsReceivableNetDetails">
        <link:definition>9955524 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES AND USE OF ESTIMATES - Gross Product Sales and Accounts Receivable Net (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSFinancialInstrumentsMeasuredatFairValueDetails" roleURI="http://tarsusrx.com/role/FAIRVALUEMEASUREMENTSFinancialInstrumentsMeasuredatFairValueDetails">
        <link:definition>9955525 - Disclosure - FAIR VALUE MEASUREMENTS - Financial Instruments Measured at Fair Value (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSEstimatedFairValueofCashCashEquivalentsMarketableSecuritiesandEquitySecuritiesDetails" roleURI="http://tarsusrx.com/role/FAIRVALUEMEASUREMENTSEstimatedFairValueofCashCashEquivalentsMarketableSecuritiesandEquitySecuritiesDetails">
        <link:definition>9955526 - Disclosure - FAIR VALUE MEASUREMENTS - Estimated Fair Value of Cash, Cash Equivalents, Marketable Securities, and Equity Securities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FAIRVALUEMEASUREMENTSAdditionalInformationDetails" roleURI="http://tarsusrx.com/role/FAIRVALUEMEASUREMENTSAdditionalInformationDetails">
        <link:definition>9955527 - Disclosure - FAIR VALUE MEASUREMENTS - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BALANCESHEETACCOUNTDETAILInventoryDetails" roleURI="http://tarsusrx.com/role/BALANCESHEETACCOUNTDETAILInventoryDetails">
        <link:definition>9955528 - Disclosure - BALANCE SHEET ACCOUNT DETAIL - Inventory (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BALANCESHEETACCOUNTDETAILPropertyandEquipmentNetDetails" roleURI="http://tarsusrx.com/role/BALANCESHEETACCOUNTDETAILPropertyandEquipmentNetDetails">
        <link:definition>9955529 - Disclosure - BALANCE SHEET ACCOUNT DETAIL - Property and Equipment, Net (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BALANCESHEETACCOUNTDETAILAdditionalInformationDetails" roleURI="http://tarsusrx.com/role/BALANCESHEETACCOUNTDETAILAdditionalInformationDetails">
        <link:definition>9955530 - Disclosure - BALANCE SHEET ACCOUNT DETAIL - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BALANCESHEETACCOUNTDETAILScheduleofIntangibleAssetsNetDetails" roleURI="http://tarsusrx.com/role/BALANCESHEETACCOUNTDETAILScheduleofIntangibleAssetsNetDetails">
        <link:definition>9955531 - Disclosure - BALANCE SHEET ACCOUNT DETAIL - Schedule of Intangible Assets, Net (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BALANCESHEETACCOUNTDETAILScheduleofExpectedFutureAmortizationExpenseDetails" roleURI="http://tarsusrx.com/role/BALANCESHEETACCOUNTDETAILScheduleofExpectedFutureAmortizationExpenseDetails">
        <link:definition>9955532 - Disclosure - BALANCE SHEET ACCOUNT DETAIL - Schedule of Expected Future Amortization Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BALANCESHEETACCOUNTDETAILAccountsPayableandAccruedLiabilitiesDetails" roleURI="http://tarsusrx.com/role/BALANCESHEETACCOUNTDETAILAccountsPayableandAccruedLiabilitiesDetails">
        <link:definition>9955533 - Disclosure - BALANCE SHEET ACCOUNT DETAIL - Accounts Payable and Accrued Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STOCKHOLDERSEQUITYAdditionalInformationDetails" roleURI="http://tarsusrx.com/role/STOCKHOLDERSEQUITYAdditionalInformationDetails">
        <link:definition>9955534 - Disclosure - STOCKHOLDERS&#8217; EQUITY - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STOCKHOLDERSEQUITYSharesReservedforIssuanceDetails" roleURI="http://tarsusrx.com/role/STOCKHOLDERSEQUITYSharesReservedforIssuanceDetails">
        <link:definition>9955535 - Disclosure - STOCKHOLDERS&#8217; EQUITY - Shares Reserved for Issuance (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STOCKBASEDCOMPENSATIONExpenseDetails" roleURI="http://tarsusrx.com/role/STOCKBASEDCOMPENSATIONExpenseDetails">
        <link:definition>9955536 - Disclosure - STOCK-BASED COMPENSATION - Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STOCKBASEDCOMPENSATIONEquityExpenseDetails" roleURI="http://tarsusrx.com/role/STOCKBASEDCOMPENSATIONEquityExpenseDetails">
        <link:definition>9955537 - Disclosure - STOCK-BASED COMPENSATION - Equity Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STOCKBASEDCOMPENSATIONUnrecognizedStockBasedCompensationExpenseDetails" roleURI="http://tarsusrx.com/role/STOCKBASEDCOMPENSATIONUnrecognizedStockBasedCompensationExpenseDetails">
        <link:definition>9955538 - Disclosure - STOCK-BASED COMPENSATION - Unrecognized Stock Based Compensation Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STOCKBASEDCOMPENSATIONValuationAssumptionsofStockOptionsDetails" roleURI="http://tarsusrx.com/role/STOCKBASEDCOMPENSATIONValuationAssumptionsofStockOptionsDetails">
        <link:definition>9955539 - Disclosure - STOCK-BASED COMPENSATION - Valuation Assumptions of Stock Options (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STOCKBASEDCOMPENSATIONStockOptionActivityDetails" roleURI="http://tarsusrx.com/role/STOCKBASEDCOMPENSATIONStockOptionActivityDetails">
        <link:definition>9955540 - Disclosure - STOCK-BASED COMPENSATION - Stock Option Activity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STOCKBASEDCOMPENSATIONAdditionalInformationDetails" roleURI="http://tarsusrx.com/role/STOCKBASEDCOMPENSATIONAdditionalInformationDetails">
        <link:definition>9955541 - Disclosure - STOCK-BASED COMPENSATION - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STOCKBASEDCOMPENSATIONRestrictedStockUnitActivityDetails" roleURI="http://tarsusrx.com/role/STOCKBASEDCOMPENSATIONRestrictedStockUnitActivityDetails">
        <link:definition>9955542 - Disclosure - STOCK-BASED COMPENSATION - Restricted Stock Unit Activity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="STOCKBASEDCOMPENSATIONScheduleofPerformanceStockUnitActivityDetails" roleURI="http://tarsusrx.com/role/STOCKBASEDCOMPENSATIONScheduleofPerformanceStockUnitActivityDetails">
        <link:definition>9955543 - Disclosure - STOCK-BASED COMPENSATION - Schedule of Performance Stock Unit Activity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NETLOSSPERSHAREDetails" roleURI="http://tarsusrx.com/role/NETLOSSPERSHAREDetails">
        <link:definition>9955544 - Disclosure - NET LOSS PER SHARE (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NETLOSSPERSHAREAntidilutiveSecuritiesDetails" roleURI="http://tarsusrx.com/role/NETLOSSPERSHAREAntidilutiveSecuritiesDetails">
        <link:definition>9955545 - Disclosure - NET LOSS PER SHARE - Antidilutive Securities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SEGMENTREPORTINGAdditionalInformationDetails" roleURI="http://tarsusrx.com/role/SEGMENTREPORTINGAdditionalInformationDetails">
        <link:definition>9955546 - Disclosure - SEGMENT REPORTING - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SEGMENTREPORTINGScheduleofOperatingFinancialResultsofTherapeuticsSegmentDetails" roleURI="http://tarsusrx.com/role/SEGMENTREPORTINGScheduleofOperatingFinancialResultsofTherapeuticsSegmentDetails">
        <link:definition>9955547 - Disclosure - SEGMENT REPORTING - Schedule of Operating Financial Results of Therapeutics Segment (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SEGMENTREPORTINGOtherSegmentDisclosuresDetails" roleURI="http://tarsusrx.com/role/SEGMENTREPORTINGOtherSegmentDisclosuresDetails">
        <link:definition>9955548 - Disclosure - SEGMENT REPORTING - Other Segment Disclosures (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSCONTINGENCIESLeaseAgreementsDetails" roleURI="http://tarsusrx.com/role/COMMITMENTSCONTINGENCIESLeaseAgreementsDetails">
        <link:definition>9955549 - Disclosure - COMMITMENTS&#160;&amp; CONTINGENCIES - Lease Agreements (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSCONTINGENCIESLeaseCostDetails" roleURI="http://tarsusrx.com/role/COMMITMENTSCONTINGENCIESLeaseCostDetails">
        <link:definition>9955550 - Disclosure - COMMITMENTS&#160;&amp; CONTINGENCIES - Lease Cost (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSCONTINGENCIESOtherInformationDetails" roleURI="http://tarsusrx.com/role/COMMITMENTSCONTINGENCIESOtherInformationDetails">
        <link:definition>9955551 - Disclosure - COMMITMENTS&#160;&amp; CONTINGENCIES - Other Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSCONTINGENCIESSummaryofMinimumLeasePaymentsDetails" roleURI="http://tarsusrx.com/role/COMMITMENTSCONTINGENCIESSummaryofMinimumLeasePaymentsDetails">
        <link:definition>9955552 - Disclosure - COMMITMENTS&#160;&amp; CONTINGENCIES - Summary of Minimum Lease Payments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSCONTINGENCIESSummaryofMinimumLeasePaymentsDetails_1" roleURI="http://tarsusrx.com/role/COMMITMENTSCONTINGENCIESSummaryofMinimumLeasePaymentsDetails_1">
        <link:definition>9955552 - Disclosure - COMMITMENTS&#160;&amp; CONTINGENCIES - Summary of Minimum Lease Payments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSCONTINGENCIESInLicenseAgreementsDetails" roleURI="http://tarsusrx.com/role/COMMITMENTSCONTINGENCIESInLicenseAgreementsDetails">
        <link:definition>9955553 - Disclosure - COMMITMENTS&#160;&amp; CONTINGENCIES - In-License Agreements (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="COMMITMENTSCONTINGENCIESEmploymentAgreementsDetails" roleURI="http://tarsusrx.com/role/COMMITMENTSCONTINGENCIESEmploymentAgreementsDetails">
        <link:definition>9955554 - Disclosure - COMMITMENTS&#160;&amp; CONTINGENCIES - Employment Agreements (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OUTLICENSEAGREEMENTSDetails" roleURI="http://tarsusrx.com/role/OUTLICENSEAGREEMENTSDetails">
        <link:definition>9955555 - Disclosure - OUT-LICENSE AGREEMENTS (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CREDITFACILITYAGREEMENTSAdditionalInformationDetails" roleURI="http://tarsusrx.com/role/CREDITFACILITYAGREEMENTSAdditionalInformationDetails">
        <link:definition>9955556 - Disclosure - CREDIT FACILITY AGREEMENTS - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CREDITFACILITYAGREEMENTSSummaryofInterestExpenseDetails" roleURI="http://tarsusrx.com/role/CREDITFACILITYAGREEMENTSSummaryofInterestExpenseDetails">
        <link:definition>9955557 - Disclosure - CREDIT FACILITY AGREEMENTS - Summary of Interest Expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CREDITFACILITYAGREEMENTSBalancesofDebtDebtIssuanceCostsandAccumulatedAccretionDetails" roleURI="http://tarsusrx.com/role/CREDITFACILITYAGREEMENTSBalancesofDebtDebtIssuanceCostsandAccumulatedAccretionDetails">
        <link:definition>9955558 - Disclosure - CREDIT FACILITY AGREEMENTS - Balances of Debt, Debt Issuance Costs, and Accumulated Accretion (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESComponentsofLossfromOperationsBeforeProvisionforIncomeTaxesDetails" roleURI="http://tarsusrx.com/role/INCOMETAXESComponentsofLossfromOperationsBeforeProvisionforIncomeTaxesDetails">
        <link:definition>9955559 - Disclosure - INCOME TAXES - Components of Loss from Operations Before Provision for Income Taxes (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESFederalandStateIncomeTaxProvisionBenefitDetails" roleURI="http://tarsusrx.com/role/INCOMETAXESFederalandStateIncomeTaxProvisionBenefitDetails">
        <link:definition>9955560 - Disclosure - INCOME TAXES - Federal and State Income Tax Provision (Benefit) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESReconciliationofIncomeTaxesDetails" roleURI="http://tarsusrx.com/role/INCOMETAXESReconciliationofIncomeTaxesDetails">
        <link:definition>9955561 - Disclosure - INCOME TAXES - Reconciliation of Income Taxes (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESTaxEffectsofSignificantItemsofDeferredTaxAssetsandLiabilitiesDetails" roleURI="http://tarsusrx.com/role/INCOMETAXESTaxEffectsofSignificantItemsofDeferredTaxAssetsandLiabilitiesDetails">
        <link:definition>9955562 - Disclosure - INCOME TAXES - Tax Effects of Significant Items of Deferred Tax Assets and Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESAdditionalInformationDetails" roleURI="http://tarsusrx.com/role/INCOMETAXESAdditionalInformationDetails">
        <link:definition>9955563 - Disclosure - INCOME TAXES - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="INCOMETAXESGrossUnrecognizedTaxBenefitsDetails" roleURI="http://tarsusrx.com/role/INCOMETAXESGrossUnrecognizedTaxBenefitsDetails">
        <link:definition>9955564 - Disclosure - INCOME TAXES - Gross Unrecognized Tax Benefits (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RELATEDPARTYTRANSACTIONSAdditionalInformationDetails" roleURI="http://tarsusrx.com/role/RELATEDPARTYTRANSACTIONSAdditionalInformationDetails">
        <link:definition>9955565 - Disclosure - RELATED PARTY TRANSACTIONS - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EMPLOYEEBENEFITPLANDetails" roleURI="http://tarsusrx.com/role/EMPLOYEEBENEFITPLANDetails">
        <link:definition>9955566 - Disclosure - EMPLOYEE BENEFIT PLAN (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SUBSEQUENTEVENTDetails" roleURI="http://tarsusrx.com/role/SUBSEQUENTEVENTDetails">
        <link:definition>9955567 - Disclosure - SUBSEQUENT EVENT (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:element id="tars_AuditInformationAbstract" abstract="true" name="AuditInformationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="tars_LicenseAndCollaborationMember" abstract="true" name="LicenseAndCollaborationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_A2023ATMProspectusMember" abstract="true" name="A2023ATMProspectusMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_ClassOfWarrantOrRightPaymentsOfIssuanceCosts" abstract="false" name="ClassOfWarrantOrRightPaymentsOfIssuanceCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tars_OperatingLeaseNoncashExpense" abstract="false" name="OperatingLeaseNoncashExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tars_LeaseModificationExpenseNonCash" abstract="false" name="LeaseModificationExpenseNonCash" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tars_DeferredOfferingCostsIncurredButNotYetPaidIncludedInAccountsPayableAndAccruedLiabilities" abstract="false" name="DeferredOfferingCostsIncurredButNotYetPaidIncludedInAccountsPayableAndAccruedLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tars_FollowOnPublicOfferingMember" abstract="true" name="FollowOnPublicOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_A2023ShelfRegistrationStatementMember" abstract="true" name="A2023ShelfRegistrationStatementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_SaleOfStockConsiderationAmountAuthorized" abstract="false" name="SaleOfStockConsiderationAmountAuthorized" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tars_ClassOfWarrantOrRightSalePrice" abstract="false" name="ClassOfWarrantOrRightSalePrice" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="tars_ClassOfWarrantOrRightReservedForFutureIssuance" abstract="false" name="ClassOfWarrantOrRightReservedForFutureIssuance" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tars_SaleOfStockUnderwriterPurchaseOptionTerm" abstract="false" name="SaleOfStockUnderwriterPurchaseOptionTerm" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="tars_SaleOfStockSalesAgentFeePercentageOfGrossProceeds" abstract="false" name="SaleOfStockSalesAgentFeePercentageOfGrossProceeds" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="tars_EquityIncentivePlan2016Member" abstract="true" name="EquityIncentivePlan2016Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_MajorCustomersMember" abstract="true" name="MajorCustomersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_CustomerAMember" abstract="true" name="CustomerAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_CustomerBMember" abstract="true" name="CustomerBMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_CustomerCMember" abstract="true" name="CustomerCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_CustomerDMember" abstract="true" name="CustomerDMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_CustomerEMember" abstract="true" name="CustomerEMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_CustomerFMember" abstract="true" name="CustomerFMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_DebtSecuritiesAvailableForSaleAndCashAndCashEquivalents" abstract="false" name="DebtSecuritiesAvailableForSaleAndCashAndCashEquivalents" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tars_CashAndCashEquivalentsAccumulatedUnrealizedGainsBeforeTax" abstract="false" name="CashAndCashEquivalentsAccumulatedUnrealizedGainsBeforeTax" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tars_AvailableForSaleDebtSecuritiesContractualMaturityGreaterThan12MonthsMember" abstract="true" name="AvailableForSaleDebtSecuritiesContractualMaturityGreaterThan12MonthsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_DebtSecuritiesAvailableForSaleContractualMaturitiesGreaterThanTwelveMonthsNumberOfSecurities" abstract="false" name="DebtSecuritiesAvailableForSaleContractualMaturitiesGreaterThanTwelveMonthsNumberOfSecurities" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tars_InventoryRawMaterialsNoncurrentNetOfReserves" abstract="false" name="InventoryRawMaterialsNoncurrentNetOfReserves" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tars_InventoryCurrentAndNoncurrentNet" abstract="false" name="InventoryCurrentAndNoncurrentNet" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tars_IntangibleAssetsMilestonePaymentMember" abstract="true" name="IntangibleAssetsMilestonePaymentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_AccruedRoyaltyPayableCurrent" abstract="false" name="AccruedRoyaltyPayableCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tars_EquityIncentivePlan2020Member" abstract="true" name="EquityIncentivePlan2020Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_CommonStockCapitalSharesReservedForFutureIssuanceAnnualPercentageIncrease" abstract="false" name="CommonStockCapitalSharesReservedForFutureIssuanceAnnualPercentageIncrease" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="tars_ShareBasedCompensationArrangementByShareBasedPaymentAwardOfferingPeriod" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOfferingPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="tars_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumEmployeeSubscriptionAmount" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumEmployeeSubscriptionAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tars_CommonStockCapitalSharesReservedForFutureIssuanceAnnualSharesIncrease" abstract="false" name="CommonStockCapitalSharesReservedForFutureIssuanceAnnualSharesIncrease" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tars_CommonStockNumberOfVotes" abstract="false" name="CommonStockNumberOfVotes" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tars_CommonStockCapitalSharesReservedForFutureIssuanceEffectOfStockAwardsAvailableForFutureGrant" abstract="false" name="CommonStockCapitalSharesReservedForFutureIssuanceEffectOfStockAwardsAvailableForFutureGrant" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tars_CommonStockCapitalSharesReservedForFutureIssuanceEmployeeStockPurchasePlan" abstract="false" name="CommonStockCapitalSharesReservedForFutureIssuanceEmployeeStockPurchasePlan" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tars_CommonStockCapitalSharesReservedForFutureIssuanceEffectOfStockOptionsIssuedAndOutstanding" abstract="false" name="CommonStockCapitalSharesReservedForFutureIssuanceEffectOfStockOptionsIssuedAndOutstanding" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tars_CommonStockCapitalSharesReservedForFutureIssuanceEffectOfRestrictedStockUnitsAvailableForFutureGrant" abstract="false" name="CommonStockCapitalSharesReservedForFutureIssuanceEffectOfRestrictedStockUnitsAvailableForFutureGrant" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tars_CommonStockCapitalSharesReservedForFutureIssuanceEffectOfPerformanceStockUnitsAvailableForFutureGrants" abstract="false" name="CommonStockCapitalSharesReservedForFutureIssuanceEffectOfPerformanceStockUnitsAvailableForFutureGrants" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="tars_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTermAbstract" abstract="true" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTermAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="tars_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsNonvestedWeightedAverageRemainingContractualTerm" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsNonvestedWeightedAverageRemainingContractualTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="tars_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" abstract="true" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAggregateIntrinsicValueAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="tars_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsNonvestedAggregateIntrinsicValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsNonvestedAggregateIntrinsicValue" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tars_ShareBasedPaymentArrangementEquityInstrumentsOtherThanOptionsRestrictedStockUnitsUnvestedMember" abstract="true" name="ShareBasedPaymentArrangementEquityInstrumentsOtherThanOptionsRestrictedStockUnitsUnvestedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_ReportableSegmentMember" abstract="true" name="ReportableSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_LesseeOperatingLeaseNumberOfLeaseContracts" abstract="false" name="LesseeOperatingLeaseNumberOfLeaseContracts" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tars_LesseeOperatingLeaseAnnualRentIncreasePercent" abstract="false" name="LesseeOperatingLeaseAnnualRentIncreasePercent" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="tars_LesseeTenantImprovementAllowance" abstract="false" name="LesseeTenantImprovementAllowance" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tars_LesseeOperatingLeaseLiabilityTenantImprovementAllowance" abstract="false" name="LesseeOperatingLeaseLiabilityTenantImprovementAllowance" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tars_ElancoMember" abstract="true" name="ElancoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_ClinicalMilestonesMember" abstract="true" name="ClinicalMilestonesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_CommercialAndSalesMilestonesMember" abstract="true" name="CommercialAndSalesMilestonesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_SalesBasedMilestonesMember" abstract="true" name="SalesBasedMilestonesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_EventBasedDevelopmentMilestoneMember" abstract="true" name="EventBasedDevelopmentMilestoneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_CommercialSalesMilestonePaymentsMember" abstract="true" name="CommercialSalesMilestonePaymentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_CollaborativeArrangementRightsAndObligationsUpfrontPayment" abstract="false" name="CollaborativeArrangementRightsAndObligationsUpfrontPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tars_CollaborativeArrangementRightsAndObligationsContractualMilestoneNetSales" abstract="false" name="CollaborativeArrangementRightsAndObligationsContractualMilestoneNetSales" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tars_CollaborativeArrangementFutureCashPayments" abstract="false" name="CollaborativeArrangementFutureCashPayments" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tars_CollaborativeArrangementMaximumMilestonePayment" abstract="false" name="CollaborativeArrangementMaximumMilestonePayment" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tars_NumberOfEmploymentArrangementsWithExecutiveOfficers" abstract="false" name="NumberOfEmploymentArrangementsWithExecutiveOfficers" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tars_LianBioMember" abstract="true" name="LianBioMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_GrandPharmaMember" abstract="true" name="GrandPharmaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_MilestoneDeterminedByTheCompanyMember" abstract="true" name="MilestoneDeterminedByTheCompanyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_DevelopmentAndRegulatoryMilestoneMember" abstract="true" name="DevelopmentAndRegulatoryMilestoneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_UponExecutionOfTheNovationAgreementMember" abstract="true" name="UponExecutionOfTheNovationAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_UponExecutionOfWarrantTerminationAgreementMember" abstract="true" name="UponExecutionOfWarrantTerminationAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_RevenueRemainingPerformanceObligationAdditionalCashPayment" abstract="false" name="RevenueRemainingPerformanceObligationAdditionalCashPayment" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tars_RevenueRemainingPerformanceObligationVariableConsiderationAmount" abstract="false" name="RevenueRemainingPerformanceObligationVariableConsiderationAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tars_ProceedsFromCancellationOfWarrants" abstract="false" name="ProceedsFromCancellationOfWarrants" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tars_UpfrontPayment" abstract="false" name="UpfrontPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tars_PharmakonCreditFacilityTrancheOneMember" abstract="true" name="PharmakonCreditFacilityTrancheOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_PharmakonCreditFacilityMember" abstract="true" name="PharmakonCreditFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_PharmakonCreditFacilityTrancheTwoMember" abstract="true" name="PharmakonCreditFacilityTrancheTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_PharmakonCreditFacilityTrancheThreeMember" abstract="true" name="PharmakonCreditFacilityTrancheThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_DebtInstrumentNumberOfPotentialAdditionalTranches" abstract="false" name="DebtInstrumentNumberOfPotentialAdditionalTranches" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tars_DebtInstrumentNumberOfTranchesWithMilestoneRequirements" abstract="false" name="DebtInstrumentNumberOfTranchesWithMilestoneRequirements" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="tars_DebtInstrumentFloorInterestRate" abstract="false" name="DebtInstrumentFloorInterestRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="tars_LineOfCreditFacilityPeriodicPaymentInterestRate" abstract="false" name="LineOfCreditFacilityPeriodicPaymentInterestRate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="tars_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseExecutiveCompensationAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationNondeductibleExpenseExecutiveCompensationAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tars_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseExecutiveCompensationPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationNondeductibleExpenseExecutiveCompensationPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="tars_DeferredTaxAssetsOperatingLeaseLiability" abstract="false" name="DeferredTaxAssetsOperatingLeaseLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="tars_AfterTaxYear2025Member" abstract="true" name="AfterTaxYear2025Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_BobakAzamianMember" abstract="true" name="BobakAzamianMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_AnteriorInLicenseAgreementMember" abstract="true" name="AnteriorInLicenseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_SeshadriNeervannanMember" abstract="true" name="SeshadriNeervannanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="tars_Dr.AzamianMember" abstract="true" name="Dr.AzamianMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
