<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2021 Workiva-->
<!--r:c2a5dd4c-0714-4e6d-9d69-9dcdcf656cb9,g:98d4a9ec-f750-4120-90cd-b8b7f0f2ca8d-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://tarsusrx.com/role/Cover" xlink:type="simple" xlink:href="tars-20210331.xsd#Cover"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_946d6905-1a2e-4679-93c7-c20fd5fe21ba" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_fd717ba5-ae5a-4760-be03-b728ddea26ba" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_946d6905-1a2e-4679-93c7-c20fd5fe21ba" xlink:to="loc_dei_DocumentType_fd717ba5-ae5a-4760-be03-b728ddea26ba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_5e9a8946-dbd6-4080-ab8b-9a8229853740" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_946d6905-1a2e-4679-93c7-c20fd5fe21ba" xlink:to="loc_dei_DocumentPeriodEndDate_5e9a8946-dbd6-4080-ab8b-9a8229853740" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_f67bd73d-4bfa-4377-94d0-f1ac9672af09" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_946d6905-1a2e-4679-93c7-c20fd5fe21ba" xlink:to="loc_dei_EntityRegistrantName_f67bd73d-4bfa-4377-94d0-f1ac9672af09" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_43b0c75e-d0a6-476d-b469-a69502cba41c" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_946d6905-1a2e-4679-93c7-c20fd5fe21ba" xlink:to="loc_dei_EntityIncorporationStateCountryCode_43b0c75e-d0a6-476d-b469-a69502cba41c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_c543cd43-82d1-48ec-8770-d247fa97a0d2" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_946d6905-1a2e-4679-93c7-c20fd5fe21ba" xlink:to="loc_dei_EntityFileNumber_c543cd43-82d1-48ec-8770-d247fa97a0d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_09884477-9951-4d91-b91c-5b9e3c8682cc" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_946d6905-1a2e-4679-93c7-c20fd5fe21ba" xlink:to="loc_dei_EntityTaxIdentificationNumber_09884477-9951-4d91-b91c-5b9e3c8682cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_8f45696d-3dd1-4f78-888f-298bb703dce9" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_946d6905-1a2e-4679-93c7-c20fd5fe21ba" xlink:to="loc_dei_EntityAddressAddressLine1_8f45696d-3dd1-4f78-888f-298bb703dce9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_e5e1f126-e8c0-4099-9c7b-08e8f7bcc272" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_946d6905-1a2e-4679-93c7-c20fd5fe21ba" xlink:to="loc_dei_EntityAddressCityOrTown_e5e1f126-e8c0-4099-9c7b-08e8f7bcc272" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_ee39975a-60e7-4d5b-b677-430f3e4c0a45" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_946d6905-1a2e-4679-93c7-c20fd5fe21ba" xlink:to="loc_dei_EntityAddressStateOrProvince_ee39975a-60e7-4d5b-b677-430f3e4c0a45" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_97825b16-e1ed-4d88-a048-f53f71be2784" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_946d6905-1a2e-4679-93c7-c20fd5fe21ba" xlink:to="loc_dei_EntityAddressPostalZipCode_97825b16-e1ed-4d88-a048-f53f71be2784" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_6702bedc-5753-432a-95fa-c173be992c09" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_946d6905-1a2e-4679-93c7-c20fd5fe21ba" xlink:to="loc_dei_CityAreaCode_6702bedc-5753-432a-95fa-c173be992c09" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_434bc4b9-a1fc-42b8-9cb5-fff91ae78a35" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_946d6905-1a2e-4679-93c7-c20fd5fe21ba" xlink:to="loc_dei_LocalPhoneNumber_434bc4b9-a1fc-42b8-9cb5-fff91ae78a35" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_2fb41e50-86c9-45a5-9f54-378cf0eff811" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_946d6905-1a2e-4679-93c7-c20fd5fe21ba" xlink:to="loc_dei_WrittenCommunications_2fb41e50-86c9-45a5-9f54-378cf0eff811" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_7541c822-76a3-4855-ad26-3df2666858f4" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_946d6905-1a2e-4679-93c7-c20fd5fe21ba" xlink:to="loc_dei_SolicitingMaterial_7541c822-76a3-4855-ad26-3df2666858f4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_67fd72a4-bc0a-401a-84ef-a18370b52844" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_946d6905-1a2e-4679-93c7-c20fd5fe21ba" xlink:to="loc_dei_PreCommencementTenderOffer_67fd72a4-bc0a-401a-84ef-a18370b52844" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_1235c2bd-8100-4cfb-b1e4-0b777047a3e2" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_946d6905-1a2e-4679-93c7-c20fd5fe21ba" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_1235c2bd-8100-4cfb-b1e4-0b777047a3e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_85676695-6061-4b5f-a158-f8009176327a" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_946d6905-1a2e-4679-93c7-c20fd5fe21ba" xlink:to="loc_dei_Security12bTitle_85676695-6061-4b5f-a158-f8009176327a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_f52a73e2-23ef-4df9-9960-c2eed935025e" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_946d6905-1a2e-4679-93c7-c20fd5fe21ba" xlink:to="loc_dei_TradingSymbol_f52a73e2-23ef-4df9-9960-c2eed935025e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_7e8deb0f-28e4-4c80-99a4-7b7d27bc0ae3" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_946d6905-1a2e-4679-93c7-c20fd5fe21ba" xlink:to="loc_dei_SecurityExchangeName_7e8deb0f-28e4-4c80-99a4-7b7d27bc0ae3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_27d4c753-2de5-455a-8820-297b51cf957d" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_946d6905-1a2e-4679-93c7-c20fd5fe21ba" xlink:to="loc_dei_EntityEmergingGrowthCompany_27d4c753-2de5-455a-8820-297b51cf957d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityExTransitionPeriod_16ebabc8-1b11-4723-9862-dcc0664ef57a" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityExTransitionPeriod"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_946d6905-1a2e-4679-93c7-c20fd5fe21ba" xlink:to="loc_dei_EntityExTransitionPeriod_16ebabc8-1b11-4723-9862-dcc0664ef57a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_42a1f1d4-9400-414c-a0e0-9ed53b7d32ea" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_946d6905-1a2e-4679-93c7-c20fd5fe21ba" xlink:to="loc_dei_EntityCentralIndexKey_42a1f1d4-9400-414c-a0e0-9ed53b7d32ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_be9fd8d1-5184-42cc-9abd-f887276148dd" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_946d6905-1a2e-4679-93c7-c20fd5fe21ba" xlink:to="loc_dei_AmendmentFlag_be9fd8d1-5184-42cc-9abd-f887276148dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
