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Disclosure - Summary of Significant Accounting Policies and Use of Estimates link:presentationLink link:calculationLink link:definitionLink 0000011 - Disclosure - Balance Sheet Account Detail link:presentationLink link:calculationLink link:definitionLink 0000012 - Disclosure - Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 0000013 - Disclosure - Stock-Based Compensation link:presentationLink link:calculationLink link:definitionLink 0000014 - Disclosure - Net Loss Per Share link:presentationLink link:calculationLink link:definitionLink 0000015 - Disclosure - Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 0000016 - Disclosure - Commitments & Contingencies link:presentationLink link:calculationLink link:definitionLink 0000017 - Disclosure - China Out-License link:presentationLink link:calculationLink link:definitionLink 0000018 - Disclosure - Credit Facility Agreement link:presentationLink link:calculationLink link:definitionLink 0000019 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 0000020 - Disclosure - Summary of Significant Accounting Policies and Use of Estimates (Policies) link:presentationLink link:calculationLink link:definitionLink 0000021 - Disclosure - Balance Sheet Account Detail (Tables) link:presentationLink link:calculationLink link:definitionLink 0000022 - Disclosure - Stockholders' Equity (Tables) link:presentationLink link:calculationLink link:definitionLink 0000023 - Disclosure - Stock-Based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 0000024 - Disclosure - Net Loss Per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 0000025 - Disclosure - Fair Value Measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 0000026 - Disclosure - Commitments & Contingencies (Tables) link:presentationLink link:calculationLink link:definitionLink 0000027 - Disclosure - Credit Facility Agreement (Tables) link:presentationLink link:calculationLink link:definitionLink 0000028 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 0000029 - Disclosure - Description of Business and Presentation of Financial Statements (Details) link:presentationLink link:calculationLink link:definitionLink 0000030 - Disclosure - Summary of Significant Accounting Policies and Use of Estimates (Details) link:presentationLink link:calculationLink link:definitionLink 0000031 - Disclosure - Balance Sheet Account Detail - Prepaid Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 0000032 - Disclosure - Balance Sheet Account Detail - Other Receivables (Details) link:presentationLink link:calculationLink link:definitionLink 0000033 - Disclosure - Balance Sheet Account Detail - Property and Equipment, Net (Details) link:presentationLink link:calculationLink link:definitionLink 0000034 - Disclosure - Balance Sheet Account Detail - Other Assets (Details) link:presentationLink link:calculationLink link:definitionLink 0000035 - Disclosure - Balance Sheet Account Detail - Accounts Payable and Accrued Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 0000036 - Disclosure - Balance Sheet Account Detail - Other Long-Term Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 0000037 - Disclosure - Stockholders' Equity - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 0000038 - Disclosure - Stockholders' Equity - Shares Reserved for Issuance (Details) link:presentationLink link:calculationLink link:definitionLink 0000039 - Disclosure - Stock-Based Compensation - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 0000040 - Disclosure - Stock-Based Compensation - Expense (Details) link:presentationLink link:calculationLink link:definitionLink 0000041 - Disclosure - Stock-Based Compensation - Valuation Assumptions of Stock Options (Details) link:presentationLink link:calculationLink link:definitionLink 0000042 - Disclosure - Stock-Based Compensation - Stock Option Activity (Details) link:presentationLink link:calculationLink link:definitionLink 0000043 - Disclosure - Stock-Based Compensation - Restricted Stock Unit Activity (Details) link:presentationLink link:calculationLink link:definitionLink 0000044 - Disclosure - Net Loss Per Share (Details) link:presentationLink link:calculationLink link:definitionLink 0000045 - Disclosure - Net Loss Per Share - Outstanding Potentially Dilutive Securities (Details) link:presentationLink link:calculationLink link:definitionLink 0000046 - Disclosure - Fair Value Measurements - Financial Instruments Measured at Fair Value (Details) link:presentationLink link:calculationLink link:definitionLink 0000047 - Disclosure - Fair Value Measurements - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 0000048 - Disclosure - Fair Value Measurements - Changes in Fair Value of Derivative Asset (Details) link:presentationLink link:calculationLink link:definitionLink 0000049 - Disclosure - Fair Value Measurements - Estimated Fair Value of Cash, Cash Equivalents, Marketable Securities, and Equity Securities (Details) link:presentationLink link:calculationLink link:definitionLink 0000050 - Disclosure - Commitments & Contingencies - Facility Leases (Details) link:presentationLink link:calculationLink link:definitionLink 0000051 - Disclosure - Commitment and Contingencies - Components of Lease Cost (Details) link:presentationLink link:calculationLink link:definitionLink 0000052 - Disclosure - Commitments & Contingencies - Future Contractual Lease Payments (Details) link:presentationLink link:calculationLink link:definitionLink 0000052 - Disclosure - Commitments & Contingencies - Future Contractual Lease Payments (Details) link:presentationLink link:calculationLink link:definitionLink 0000053 - Disclosure - Commitments & Contingencies - In-License Agreements for Lotilaner (Details) link:presentationLink link:calculationLink link:definitionLink 0000054 - Disclosure - Commitments & Contingencies - Employment Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 0000055 - Disclosure - China Out-License (Details) link:presentationLink link:calculationLink link:definitionLink 0000056 - Disclosure - Credit Facility Agreement (Details) link:presentationLink link:calculationLink link:definitionLink 0000057 - Disclosure - Credit Facility Agreement - Summary of Interest Expense (Details) link:presentationLink link:calculationLink link:definitionLink 0000058 - Disclosure - Credit Facility Agreement - Balances of Credit Facility and Related Accretion and Amortization (Details) link:presentationLink link:calculationLink link:definitionLink 0000059 - Disclosure - Income Taxes - Components of Loss from Operations Before Provision for Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 0000060 - Disclosure - Income Taxes - Components of Provision for Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 0000061 - Disclosure - Income Taxes - Reconciliation of Income Taxes (Details) link:presentationLink link:calculationLink link:definitionLink 0000062 - Disclosure - Income Taxes - Significant Components of Deferred Tax Assets and Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 0000063 - Disclosure - Income Taxes - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 0000064 - Disclosure - Income Taxes - Gross Unrecognized Tax Benefits (Details) link:presentationLink link:calculationLink link:definitionLink