<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2024 Workiva-->
<!--r:81c7f216-2514-4c60-a770-28f6125b3533,g:c38623ea-9ff8-444d-8b22-1d9a2425ca98-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://tarsusrx.com/role/Cover" xlink:type="simple" xlink:href="tars-20240227.xsd#Cover"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_80f0709d-f049-4ae1-9360-ee4ff0dbb338" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_ddc1db9c-13a9-4086-870b-0a335fa748b0" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_80f0709d-f049-4ae1-9360-ee4ff0dbb338" xlink:to="loc_dei_DocumentType_ddc1db9c-13a9-4086-870b-0a335fa748b0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_eb78a833-1140-4d98-b5d8-9484c22d84ca" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_80f0709d-f049-4ae1-9360-ee4ff0dbb338" xlink:to="loc_dei_DocumentPeriodEndDate_eb78a833-1140-4d98-b5d8-9484c22d84ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_1a9e2938-0331-4e37-a1aa-e667c499eeea" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_80f0709d-f049-4ae1-9360-ee4ff0dbb338" xlink:to="loc_dei_EntityRegistrantName_1a9e2938-0331-4e37-a1aa-e667c499eeea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_ceaa7abd-bd63-423c-a220-b48e0f04a6f3" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_80f0709d-f049-4ae1-9360-ee4ff0dbb338" xlink:to="loc_dei_EntityIncorporationStateCountryCode_ceaa7abd-bd63-423c-a220-b48e0f04a6f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_58aa6a2e-d4fa-4c3d-9462-a98de6ae6a41" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_80f0709d-f049-4ae1-9360-ee4ff0dbb338" xlink:to="loc_dei_EntityFileNumber_58aa6a2e-d4fa-4c3d-9462-a98de6ae6a41" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_63c0f7ae-10c6-4cd1-a0ad-fed770545b50" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_80f0709d-f049-4ae1-9360-ee4ff0dbb338" xlink:to="loc_dei_EntityTaxIdentificationNumber_63c0f7ae-10c6-4cd1-a0ad-fed770545b50" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_793eb20a-dabd-447f-9b2c-26bb4e5f0080" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_80f0709d-f049-4ae1-9360-ee4ff0dbb338" xlink:to="loc_dei_EntityAddressAddressLine1_793eb20a-dabd-447f-9b2c-26bb4e5f0080" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_da14d78d-b0a7-4743-aaf3-83b05edc649d" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_80f0709d-f049-4ae1-9360-ee4ff0dbb338" xlink:to="loc_dei_EntityAddressCityOrTown_da14d78d-b0a7-4743-aaf3-83b05edc649d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_6001e092-4698-404e-b613-8ed6f1bbc5d8" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_80f0709d-f049-4ae1-9360-ee4ff0dbb338" xlink:to="loc_dei_EntityAddressStateOrProvince_6001e092-4698-404e-b613-8ed6f1bbc5d8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_d9a77a81-033a-4652-92a6-70ed406d3821" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_80f0709d-f049-4ae1-9360-ee4ff0dbb338" xlink:to="loc_dei_EntityAddressPostalZipCode_d9a77a81-033a-4652-92a6-70ed406d3821" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_55ffbc25-1c22-4b63-871c-e53ae029d303" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_80f0709d-f049-4ae1-9360-ee4ff0dbb338" xlink:to="loc_dei_CityAreaCode_55ffbc25-1c22-4b63-871c-e53ae029d303" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_e411fd5d-1909-4bab-b7d9-6d6a9a59d6c6" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_80f0709d-f049-4ae1-9360-ee4ff0dbb338" xlink:to="loc_dei_LocalPhoneNumber_e411fd5d-1909-4bab-b7d9-6d6a9a59d6c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_4291113a-c419-4c43-8261-a2c909e08425" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_80f0709d-f049-4ae1-9360-ee4ff0dbb338" xlink:to="loc_dei_WrittenCommunications_4291113a-c419-4c43-8261-a2c909e08425" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_13dc0fff-ce66-41d9-b925-d9a27cd4d23c" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_80f0709d-f049-4ae1-9360-ee4ff0dbb338" xlink:to="loc_dei_SolicitingMaterial_13dc0fff-ce66-41d9-b925-d9a27cd4d23c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_293fecec-6be8-41f6-ab84-7696bc617191" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_80f0709d-f049-4ae1-9360-ee4ff0dbb338" xlink:to="loc_dei_PreCommencementTenderOffer_293fecec-6be8-41f6-ab84-7696bc617191" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_ba22928c-47f3-4060-a917-e5456573bcce" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_80f0709d-f049-4ae1-9360-ee4ff0dbb338" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_ba22928c-47f3-4060-a917-e5456573bcce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_92e6bdb5-6698-4e91-b4f1-01a261039b57" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_80f0709d-f049-4ae1-9360-ee4ff0dbb338" xlink:to="loc_dei_Security12bTitle_92e6bdb5-6698-4e91-b4f1-01a261039b57" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_6aa4b800-c029-47c2-9db0-4f1bcfd32e63" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_80f0709d-f049-4ae1-9360-ee4ff0dbb338" xlink:to="loc_dei_TradingSymbol_6aa4b800-c029-47c2-9db0-4f1bcfd32e63" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_d381a66e-1eb9-45f2-a7c3-932380f2e259" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_80f0709d-f049-4ae1-9360-ee4ff0dbb338" xlink:to="loc_dei_SecurityExchangeName_d381a66e-1eb9-45f2-a7c3-932380f2e259" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_16ef5a04-2ac6-42c2-9015-338ed9010413" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_80f0709d-f049-4ae1-9360-ee4ff0dbb338" xlink:to="loc_dei_EntityEmergingGrowthCompany_16ef5a04-2ac6-42c2-9015-338ed9010413" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityExTransitionPeriod_b77184d1-5380-453f-a440-a3733c66c931" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityExTransitionPeriod"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_80f0709d-f049-4ae1-9360-ee4ff0dbb338" xlink:to="loc_dei_EntityExTransitionPeriod_b77184d1-5380-453f-a440-a3733c66c931" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_2bce6d8b-643b-406f-b532-a64abc7da1cc" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_80f0709d-f049-4ae1-9360-ee4ff0dbb338" xlink:to="loc_dei_EntityCentralIndexKey_2bce6d8b-643b-406f-b532-a64abc7da1cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_6fcd073e-f29d-4947-af0a-fef3873e7104" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_80f0709d-f049-4ae1-9360-ee4ff0dbb338" xlink:to="loc_dei_AmendmentFlag_6fcd073e-f29d-4947-af0a-fef3873e7104" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
