<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2023 Workiva-->
<!--r:8f1c3737-32f2-4cca-9fdb-4af6e30a57bf,g:50981a6e-6f8d-4ebc-9eef-363103bf5917-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://tarsusrx.com/role/Cover" xlink:type="simple" xlink:href="tars-20231109.xsd#Cover"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_6bc8d3f3-5899-4a8f-b5ae-ef49009890c8" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_3cb4084b-64d1-4181-987d-524192d64dda" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6bc8d3f3-5899-4a8f-b5ae-ef49009890c8" xlink:to="loc_dei_DocumentType_3cb4084b-64d1-4181-987d-524192d64dda" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_d596a580-f3d8-4480-91c3-c3c5a56202b2" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6bc8d3f3-5899-4a8f-b5ae-ef49009890c8" xlink:to="loc_dei_DocumentPeriodEndDate_d596a580-f3d8-4480-91c3-c3c5a56202b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_ec3851ee-83e5-493e-a556-5612ec59776d" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6bc8d3f3-5899-4a8f-b5ae-ef49009890c8" xlink:to="loc_dei_EntityRegistrantName_ec3851ee-83e5-493e-a556-5612ec59776d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_315765ea-740d-41cb-902a-3e9c55f5d8ee" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6bc8d3f3-5899-4a8f-b5ae-ef49009890c8" xlink:to="loc_dei_EntityIncorporationStateCountryCode_315765ea-740d-41cb-902a-3e9c55f5d8ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_894c782e-b4f0-4f47-b07b-5982ffef15d2" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6bc8d3f3-5899-4a8f-b5ae-ef49009890c8" xlink:to="loc_dei_EntityFileNumber_894c782e-b4f0-4f47-b07b-5982ffef15d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_7f069f3b-5858-42a3-9a31-b7c98c89edeb" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6bc8d3f3-5899-4a8f-b5ae-ef49009890c8" xlink:to="loc_dei_EntityTaxIdentificationNumber_7f069f3b-5858-42a3-9a31-b7c98c89edeb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_28f198bf-3f99-4895-9ede-d5735a0a066f" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6bc8d3f3-5899-4a8f-b5ae-ef49009890c8" xlink:to="loc_dei_EntityAddressAddressLine1_28f198bf-3f99-4895-9ede-d5735a0a066f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_67246851-3fd3-47bd-8d3b-c570ea71996b" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6bc8d3f3-5899-4a8f-b5ae-ef49009890c8" xlink:to="loc_dei_EntityAddressCityOrTown_67246851-3fd3-47bd-8d3b-c570ea71996b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_e0442ca6-d7e1-4caa-ae76-9de3a3b892fe" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6bc8d3f3-5899-4a8f-b5ae-ef49009890c8" xlink:to="loc_dei_EntityAddressStateOrProvince_e0442ca6-d7e1-4caa-ae76-9de3a3b892fe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_0734d863-e811-4ba4-a996-759a84eb6d93" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6bc8d3f3-5899-4a8f-b5ae-ef49009890c8" xlink:to="loc_dei_EntityAddressPostalZipCode_0734d863-e811-4ba4-a996-759a84eb6d93" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_d88556c2-c64b-41cc-a05f-55348448b78a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6bc8d3f3-5899-4a8f-b5ae-ef49009890c8" xlink:to="loc_dei_CityAreaCode_d88556c2-c64b-41cc-a05f-55348448b78a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_f8e54b71-2e06-460e-ae1e-976c97fab5fc" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6bc8d3f3-5899-4a8f-b5ae-ef49009890c8" xlink:to="loc_dei_LocalPhoneNumber_f8e54b71-2e06-460e-ae1e-976c97fab5fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_6f7e13f5-8f77-4258-b3de-5d70cb66902d" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6bc8d3f3-5899-4a8f-b5ae-ef49009890c8" xlink:to="loc_dei_WrittenCommunications_6f7e13f5-8f77-4258-b3de-5d70cb66902d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_7f5b5111-a8f4-414f-8eed-bef89062541a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6bc8d3f3-5899-4a8f-b5ae-ef49009890c8" xlink:to="loc_dei_SolicitingMaterial_7f5b5111-a8f4-414f-8eed-bef89062541a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_58116a3b-f404-4046-b0f1-293be436dbea" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6bc8d3f3-5899-4a8f-b5ae-ef49009890c8" xlink:to="loc_dei_PreCommencementTenderOffer_58116a3b-f404-4046-b0f1-293be436dbea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_a9373a24-40b4-45d3-990b-b61a3b493c6c" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6bc8d3f3-5899-4a8f-b5ae-ef49009890c8" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_a9373a24-40b4-45d3-990b-b61a3b493c6c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_cf31f164-b72b-4b08-9d13-20456b14daf0" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6bc8d3f3-5899-4a8f-b5ae-ef49009890c8" xlink:to="loc_dei_Security12bTitle_cf31f164-b72b-4b08-9d13-20456b14daf0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_9632b5d0-a38c-4698-9b48-16620b7fdafc" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6bc8d3f3-5899-4a8f-b5ae-ef49009890c8" xlink:to="loc_dei_TradingSymbol_9632b5d0-a38c-4698-9b48-16620b7fdafc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_747f3ec0-8ae8-47a6-9c8a-459fdfc293e1" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6bc8d3f3-5899-4a8f-b5ae-ef49009890c8" xlink:to="loc_dei_EntityEmergingGrowthCompany_747f3ec0-8ae8-47a6-9c8a-459fdfc293e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityExTransitionPeriod_e1c8646f-7a6f-4794-a391-e7b8926e96c1" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityExTransitionPeriod"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6bc8d3f3-5899-4a8f-b5ae-ef49009890c8" xlink:to="loc_dei_EntityExTransitionPeriod_e1c8646f-7a6f-4794-a391-e7b8926e96c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_9238aeaa-7d1b-43e5-ad2f-6d5d10ec69cb" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6bc8d3f3-5899-4a8f-b5ae-ef49009890c8" xlink:to="loc_dei_EntityCentralIndexKey_9238aeaa-7d1b-43e5-ad2f-6d5d10ec69cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_12229150-f455-4935-9f0e-15c198c25ca8" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6bc8d3f3-5899-4a8f-b5ae-ef49009890c8" xlink:to="loc_dei_AmendmentFlag_12229150-f455-4935-9f0e-15c198c25ca8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_183929f0-e932-4ed4-a08e-5c79fe8aaef1" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6bc8d3f3-5899-4a8f-b5ae-ef49009890c8" xlink:to="loc_dei_SecurityExchangeName_183929f0-e932-4ed4-a08e-5c79fe8aaef1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
