<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2025 Workiva-->
<!--r:b4dbe799-d85f-41f2-a4ac-9da95f5b1fbe,g:1316cc77-1e53-4da7-af1b-d95304edb213-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://tarsusrx.com/role/CONDENSEDBALANCESHEETS" xlink:type="simple" xlink:href="tars-20250630.xsd#CONDENSEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://tarsusrx.com/role/CONDENSEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_78db0fc4-2333-4fbb-8cc0-574589232a36" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent_25d7df16-9724-4348-a5e6-03af42e30be7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_78db0fc4-2333-4fbb-8cc0-574589232a36" xlink:to="loc_us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent_25d7df16-9724-4348-a5e6-03af42e30be7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_b7c630eb-e56e-4c3f-ba27-41fd391ace28" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_78db0fc4-2333-4fbb-8cc0-574589232a36" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_b7c630eb-e56e-4c3f-ba27-41fd391ace28" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_7b3df33e-c09c-4f91-b042-6a488841f970" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_02451f78-2b63-4207-910b-aba97e95148e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_7b3df33e-c09c-4f91-b042-6a488841f970" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_02451f78-2b63-4207-910b-aba97e95148e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_501f0941-5848-4bfb-88f9-e534b1bdd57a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_7b3df33e-c09c-4f91-b042-6a488841f970" xlink:to="loc_us-gaap_CommonStockValue_501f0941-5848-4bfb-88f9-e534b1bdd57a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_14f67e79-7a6c-461f-90c6-da2123057faa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_7b3df33e-c09c-4f91-b042-6a488841f970" xlink:to="loc_us-gaap_PreferredStockValue_14f67e79-7a6c-461f-90c6-da2123057faa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_02bb8ba8-5798-4d8f-bb62-c8e6bf1e22ee" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_7b3df33e-c09c-4f91-b042-6a488841f970" xlink:to="loc_us-gaap_AdditionalPaidInCapital_02bb8ba8-5798-4d8f-bb62-c8e6bf1e22ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_e7705708-ac68-4cf0-88ef-1408b81245ff" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_7b3df33e-c09c-4f91-b042-6a488841f970" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_e7705708-ac68-4cf0-88ef-1408b81245ff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_10fc6a17-5f71-4c31-ac73-2fdcafdbb23f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_5c757925-621f-43ec-bca4-1b9c7f12e939" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_10fc6a17-5f71-4c31-ac73-2fdcafdbb23f" xlink:to="loc_us-gaap_Liabilities_5c757925-621f-43ec-bca4-1b9c7f12e939" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_ef954379-0a44-4136-8e8a-4ad99b51d0d4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_10fc6a17-5f71-4c31-ac73-2fdcafdbb23f" xlink:to="loc_us-gaap_StockholdersEquity_ef954379-0a44-4136-8e8a-4ad99b51d0d4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_a2ff97cb-a30d-4f30-9d01-3bd0830a3c51" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_10fc6a17-5f71-4c31-ac73-2fdcafdbb23f" xlink:to="loc_us-gaap_CommitmentsAndContingencies_a2ff97cb-a30d-4f30-9d01-3bd0830a3c51" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_5909c568-1f9c-4064-91fc-10540d2252ff" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_db95e8d0-3d20-40dd-b3c0-10bb410bdef0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_5909c568-1f9c-4064-91fc-10540d2252ff" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_db95e8d0-3d20-40dd-b3c0-10bb410bdef0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseCurrent_c748ec17-240c-4b8f-ad3e-08d955b80582" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PrepaidExpenseCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_5909c568-1f9c-4064-91fc-10540d2252ff" xlink:to="loc_us-gaap_PrepaidExpenseCurrent_c748ec17-240c-4b8f-ad3e-08d955b80582" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherReceivablesNetCurrent_a3b3a3d5-010d-472d-badf-900b8847a394" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherReceivablesNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_5909c568-1f9c-4064-91fc-10540d2252ff" xlink:to="loc_us-gaap_OtherReceivablesNetCurrent_a3b3a3d5-010d-472d-badf-900b8847a394" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_29a57ed3-b370-4169-862c-3d7d3bbac53d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_5909c568-1f9c-4064-91fc-10540d2252ff" xlink:to="loc_us-gaap_InventoryNet_29a57ed3-b370-4169-862c-3d7d3bbac53d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_9ff185b5-090e-4c89-8229-f9c10cfa54b3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_5909c568-1f9c-4064-91fc-10540d2252ff" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_9ff185b5-090e-4c89-8229-f9c10cfa54b3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesCurrent_8b7e9fd9-0a0f-4fbc-a070-556589789f5a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_MarketableSecuritiesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_5909c568-1f9c-4064-91fc-10540d2252ff" xlink:to="loc_us-gaap_MarketableSecuritiesCurrent_8b7e9fd9-0a0f-4fbc-a070-556589789f5a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_9ad2c57e-7290-45d0-a0b1-84c001fd147a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_3050cdae-ab3b-4d49-ab1a-c511d0619b2a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_9ad2c57e-7290-45d0-a0b1-84c001fd147a" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_3050cdae-ab3b-4d49-ab1a-c511d0619b2a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_20ccd2cb-6b13-41de-91c6-5ebcfd2465c9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_9ad2c57e-7290-45d0-a0b1-84c001fd147a" xlink:to="loc_us-gaap_LiabilitiesCurrent_20ccd2cb-6b13-41de-91c6-5ebcfd2465c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_60ce1c4f-398d-44f8-bf5d-c353009be9f4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_c6e94f12-31a2-416e-a5d7-33727cec5430" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_60ce1c4f-398d-44f8-bf5d-c353009be9f4" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_c6e94f12-31a2-416e-a5d7-33727cec5430" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNoncurrent_ac7507a0-fb7f-4306-97b4-b56db238d042" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_60ce1c4f-398d-44f8-bf5d-c353009be9f4" xlink:to="loc_us-gaap_InventoryNoncurrent_ac7507a0-fb7f-4306-97b4-b56db238d042" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermInvestments_73a6f100-4e80-41f4-b147-803561016822" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermInvestments"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_60ce1c4f-398d-44f8-bf5d-c353009be9f4" xlink:to="loc_us-gaap_LongTermInvestments_73a6f100-4e80-41f4-b147-803561016822" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_2adec54c-1ae1-4636-97d2-ed1082b2ca88" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_60ce1c4f-398d-44f8-bf5d-c353009be9f4" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_2adec54c-1ae1-4636-97d2-ed1082b2ca88" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_3f8e0ba8-b98b-4fd2-a15e-d01bd1884d7c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_60ce1c4f-398d-44f8-bf5d-c353009be9f4" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_3f8e0ba8-b98b-4fd2-a15e-d01bd1884d7c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_9bfc55d4-bcd4-47c7-a7be-cc1e09ef35b2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_60ce1c4f-398d-44f8-bf5d-c353009be9f4" xlink:to="loc_us-gaap_AssetsCurrent_9bfc55d4-bcd4-47c7-a7be-cc1e09ef35b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_e0a731bb-a347-435c-8e67-b1c752d0f15e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_60ce1c4f-398d-44f8-bf5d-c353009be9f4" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_e0a731bb-a347-435c-8e67-b1c752d0f15e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_4ea4ffa7-540c-4c6d-bb13-a327804f4ffd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashNoncurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_60ce1c4f-398d-44f8-bf5d-c353009be9f4" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_4ea4ffa7-540c-4c6d-bb13-a327804f4ffd" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/CONDENSEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVELOSS" xlink:type="simple" xlink:href="tars-20250630.xsd#CONDENSEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVELOSS"/>
  <link:calculationLink xlink:role="http://tarsusrx.com/role/CONDENSEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVELOSS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_fc340474-e761-492e-bf7c-c9b53934a0b3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_f9d5ca4a-4286-41e3-bf2b-1ece6a3bf836" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_fc340474-e761-492e-bf7c-c9b53934a0b3" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_f9d5ca4a-4286-41e3-bf2b-1ece6a3bf836" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_bff8bb82-73d6-4ae8-afa5-ea11b086b6d1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_fc340474-e761-492e-bf7c-c9b53934a0b3" xlink:to="loc_us-gaap_NetIncomeLoss_bff8bb82-73d6-4ae8-afa5-ea11b086b6d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_a1e590ce-d179-42e4-92f9-6218b54ea7a4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeOther_a4c83b20-4f6a-474c-ae3d-2a9a5b878e43" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestIncomeOther"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_a1e590ce-d179-42e4-92f9-6218b54ea7a4" xlink:to="loc_us-gaap_InterestIncomeOther_a4c83b20-4f6a-474c-ae3d-2a9a5b878e43" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_7137e3ae-0c8f-41b4-a870-07a336fb6af8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_a1e590ce-d179-42e4-92f9-6218b54ea7a4" xlink:to="loc_us-gaap_InterestExpenseNonoperating_7137e3ae-0c8f-41b4-a870-07a336fb6af8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_7a1119a6-b935-46df-ae6b-b3403ed9ccc2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_a1e590ce-d179-42e4-92f9-6218b54ea7a4" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_7a1119a6-b935-46df-ae6b-b3403ed9ccc2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_be183eb4-f0ef-4b93-8c0a-a3be102deb55" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_a1e590ce-d179-42e4-92f9-6218b54ea7a4" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_be183eb4-f0ef-4b93-8c0a-a3be102deb55" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_c48b8f85-e8f7-4b9b-b5a5-a2a99dfa5e0f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_c185486f-fef6-4124-a3ce-f63e6028fbb8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_c48b8f85-e8f7-4b9b-b5a5-a2a99dfa5e0f" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_c185486f-fef6-4124-a3ce-f63e6028fbb8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_ab3b9803-ae90-4745-8a90-c0474213bb64" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_c48b8f85-e8f7-4b9b-b5a5-a2a99dfa5e0f" xlink:to="loc_us-gaap_OperatingIncomeLoss_ab3b9803-ae90-4745-8a90-c0474213bb64" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_ee0c5b89-4504-42b3-b8de-a2775cd3eae6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_e71bcd92-0961-4230-97c9-7eab1cee2c20" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostsAndExpenses"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_ee0c5b89-4504-42b3-b8de-a2775cd3eae6" xlink:to="loc_us-gaap_CostsAndExpenses_e71bcd92-0961-4230-97c9-7eab1cee2c20" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_05838aa4-65e2-4ced-a111-9d752f1b7428" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Revenues"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_ee0c5b89-4504-42b3-b8de-a2775cd3eae6" xlink:to="loc_us-gaap_Revenues_05838aa4-65e2-4ced-a111-9d752f1b7428" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/CONDENSEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="tars-20250630.xsd#CONDENSEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://tarsusrx.com/role/CONDENSEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c41ec0b3-c0a0-45f4-96be-eebd52e2f17e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_7e37b665-f0fe-442d-8311-0b7fc88c91a4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c41ec0b3-c0a0-45f4-96be-eebd52e2f17e" xlink:to="loc_us-gaap_NetIncomeLoss_7e37b665-f0fe-442d-8311-0b7fc88c91a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_72cc9172-cb61-4a0e-9add-2c7dc1db1d54" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Depreciation"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c41ec0b3-c0a0-45f4-96be-eebd52e2f17e" xlink:to="loc_us-gaap_Depreciation_72cc9172-cb61-4a0e-9add-2c7dc1db1d54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_af3aa0be-6bcf-4a41-aaa4-4de3fc307816" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c41ec0b3-c0a0-45f4-96be-eebd52e2f17e" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_af3aa0be-6bcf-4a41-aaa4-4de3fc307816" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_f53225c8-d3bc-4cd8-848b-a1ef118f5e76" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfFinancingCostsAndDiscounts"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c41ec0b3-c0a0-45f4-96be-eebd52e2f17e" xlink:to="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_f53225c8-d3bc-4cd8-848b-a1ef118f5e76" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_4d1a4874-cdc9-4b86-8119-71bd3300101a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c41ec0b3-c0a0-45f4-96be-eebd52e2f17e" xlink:to="loc_us-gaap_ShareBasedCompensation_4d1a4874-cdc9-4b86-8119-71bd3300101a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_db719f57-75eb-4629-8fa9-43b40256079a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c41ec0b3-c0a0-45f4-96be-eebd52e2f17e" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_db719f57-75eb-4629-8fa9-43b40256079a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_OperatingLeaseNoncashExpense_d70d6a60-6076-4a49-a229-9e372f6b09a7" xlink:href="tars-20250630.xsd#tars_OperatingLeaseNoncashExpense"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c41ec0b3-c0a0-45f4-96be-eebd52e2f17e" xlink:to="loc_tars_OperatingLeaseNoncashExpense_d70d6a60-6076-4a49-a229-9e372f6b09a7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_70539b1a-5544-47bf-9258-32fd9d215057" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c41ec0b3-c0a0-45f4-96be-eebd52e2f17e" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_70539b1a-5544-47bf-9258-32fd9d215057" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiRealizedGainLoss_5572b5c4-9e07-4ad6-8375-6b7701ab8ec8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquitySecuritiesFvNiRealizedGainLoss"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c41ec0b3-c0a0-45f4-96be-eebd52e2f17e" xlink:to="loc_us-gaap_EquitySecuritiesFvNiRealizedGainLoss_5572b5c4-9e07-4ad6-8375-6b7701ab8ec8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_0d42bb9b-36d2-459e-a6f8-705f387cdeac" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c41ec0b3-c0a0-45f4-96be-eebd52e2f17e" xlink:to="loc_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_0d42bb9b-36d2-459e-a6f8-705f387cdeac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_52a6ae74-b626-4e35-a509-39675c690496" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c41ec0b3-c0a0-45f4-96be-eebd52e2f17e" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_52a6ae74-b626-4e35-a509-39675c690496" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_5546ca1b-8de2-4806-8b1c-ae63e59902f4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c41ec0b3-c0a0-45f4-96be-eebd52e2f17e" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_5546ca1b-8de2-4806-8b1c-ae63e59902f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherReceivables_5ce62c70-3aa8-4ef5-abce-fa62aa5d29ed" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInOtherReceivables"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c41ec0b3-c0a0-45f4-96be-eebd52e2f17e" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherReceivables_5ce62c70-3aa8-4ef5-abce-fa62aa5d29ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidExpense_b88728fd-115d-4b1d-b282-cf704ffc8ca8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInPrepaidExpense"/>
    <link:calculationArc order="14" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c41ec0b3-c0a0-45f4-96be-eebd52e2f17e" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidExpense_b88728fd-115d-4b1d-b282-cf704ffc8ca8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_d7bea5e4-9476-4425-85e3-7ae0406cf7c4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentAssets"/>
    <link:calculationArc order="15" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c41ec0b3-c0a0-45f4-96be-eebd52e2f17e" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_d7bea5e4-9476-4425-85e3-7ae0406cf7c4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities_461be7a2-5382-44e4-850b-8e5eb0457a6d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c41ec0b3-c0a0-45f4-96be-eebd52e2f17e" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities_461be7a2-5382-44e4-850b-8e5eb0457a6d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities_9c21df1b-2a23-40d9-9f1e-b552b268a0a7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities"/>
    <link:calculationArc order="17" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c41ec0b3-c0a0-45f4-96be-eebd52e2f17e" xlink:to="loc_us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities_9c21df1b-2a23-40d9-9f1e-b552b268a0a7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_98a18430-a1a5-4f1b-acc4-480ac65e3d12" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities"/>
    <link:calculationArc order="18" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c41ec0b3-c0a0-45f4-96be-eebd52e2f17e" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_98a18430-a1a5-4f1b-acc4-480ac65e3d12" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossUnrealized_5a55b748-09de-4880-915b-2ea18b746f31" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ForeignCurrencyTransactionGainLossUnrealized"/>
    <link:calculationArc order="19" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_c41ec0b3-c0a0-45f4-96be-eebd52e2f17e" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossUnrealized_5a55b748-09de-4880-915b-2ea18b746f31" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f04ac11b-1f77-414a-8e96-c1e9d1947745" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_e9b45bc1-d8ea-4eaf-ad42-965559845c3f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f04ac11b-1f77-414a-8e96-c1e9d1947745" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_e9b45bc1-d8ea-4eaf-ad42-965559845c3f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfWarrants_a883f271-a70d-4005-ac58-492df361da46" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromIssuanceOfWarrants"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f04ac11b-1f77-414a-8e96-c1e9d1947745" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfWarrants_a883f271-a70d-4005-ac58-492df361da46" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockPlans_3c0aca79-fdc3-4eea-a025-113d6c99d1ae" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromStockPlans"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f04ac11b-1f77-414a-8e96-c1e9d1947745" xlink:to="loc_us-gaap_ProceedsFromStockPlans_3c0aca79-fdc3-4eea-a025-113d6c99d1ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_40fa25d2-c09a-4b66-bc7f-92942433dd16" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f04ac11b-1f77-414a-8e96-c1e9d1947745" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_40fa25d2-c09a-4b66-bc7f-92942433dd16" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_d2dfbd5b-fe0b-434e-bcf4-ff3fb54ab8b9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f04ac11b-1f77-414a-8e96-c1e9d1947745" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_d2dfbd5b-fe0b-434e-bcf4-ff3fb54ab8b9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtExtinguishmentCosts_61e3603e-1e84-4b04-b46a-70ba44f6eb8e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsOfDebtExtinguishmentCosts"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f04ac11b-1f77-414a-8e96-c1e9d1947745" xlink:to="loc_us-gaap_PaymentsOfDebtExtinguishmentCosts_61e3603e-1e84-4b04-b46a-70ba44f6eb8e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_9188bb10-7008-4af2-9b15-ea59a2302174" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsOfDebtIssuanceCosts"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f04ac11b-1f77-414a-8e96-c1e9d1947745" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_9188bb10-7008-4af2-9b15-ea59a2302174" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_82524df5-76fa-437e-88cf-c9519de0080a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_ee84347c-22e6-4fe7-9e5d-852151460936" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_82524df5-76fa-437e-88cf-c9519de0080a" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_ee84347c-22e6-4fe7-9e5d-852151460936" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_59f71339-f5e2-43b1-9c42-e52b9693c734" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_82524df5-76fa-437e-88cf-c9519de0080a" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_59f71339-f5e2-43b1-9c42-e52b9693c734" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireLongtermInvestments_d37a1543-ac55-47eb-bad0-4e4864c0a28b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireLongtermInvestments"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_82524df5-76fa-437e-88cf-c9519de0080a" xlink:to="loc_us-gaap_PaymentsToAcquireLongtermInvestments_d37a1543-ac55-47eb-bad0-4e4864c0a28b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_744b03b5-583d-427d-933e-273550437dee" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_82524df5-76fa-437e-88cf-c9519de0080a" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_744b03b5-583d-427d-933e-273550437dee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_83f82b54-9df0-4bce-99d3-9c71577eabb6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a3a86bdb-06ba-4d58-9ea4-ad730d7f182d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_83f82b54-9df0-4bce-99d3-9c71577eabb6" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a3a86bdb-06ba-4d58-9ea4-ad730d7f182d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_c76cd61a-9de9-49df-acf4-d9261996ae12" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_83f82b54-9df0-4bce-99d3-9c71577eabb6" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_c76cd61a-9de9-49df-acf4-d9261996ae12" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_16a64274-a03b-49e1-85f7-34748b2bd703" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_83f82b54-9df0-4bce-99d3-9c71577eabb6" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_16a64274-a03b-49e1-85f7-34748b2bd703" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/FAIRVALUEMEASUREMENTSScheduleofFinancialInstrumentsMeasuredatFairValueDetails" xlink:type="simple" xlink:href="tars-20250630.xsd#FAIRVALUEMEASUREMENTSScheduleofFinancialInstrumentsMeasuredatFairValueDetails"/>
  <link:calculationLink xlink:role="http://tarsusrx.com/role/FAIRVALUEMEASUREMENTSScheduleofFinancialInstrumentsMeasuredatFairValueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_c88bf8ec-7a83-48cf-b3d4-2bf6df3ecc5d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_DebtSecuritiesAvailableForSaleAndCashAndCashEquivalents_6640093f-b18e-4827-86e3-dbca46b49ea5" xlink:href="tars-20250630.xsd#tars_DebtSecuritiesAvailableForSaleAndCashAndCashEquivalents"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_c88bf8ec-7a83-48cf-b3d4-2bf6df3ecc5d" xlink:to="loc_tars_DebtSecuritiesAvailableForSaleAndCashAndCashEquivalents_6640093f-b18e-4827-86e3-dbca46b49ea5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_47c8b2d2-24fb-4007-b138-159c40a018ac" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_c88bf8ec-7a83-48cf-b3d4-2bf6df3ecc5d" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_47c8b2d2-24fb-4007-b138-159c40a018ac" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/FAIRVALUEMEASUREMENTSScheduleofEstimatedValueofCashCashEquivalentsMarketableSecuritiesandEquitySecuritiesDetails" xlink:type="simple" xlink:href="tars-20250630.xsd#FAIRVALUEMEASUREMENTSScheduleofEstimatedValueofCashCashEquivalentsMarketableSecuritiesandEquitySecuritiesDetails"/>
  <link:calculationLink xlink:role="http://tarsusrx.com/role/FAIRVALUEMEASUREMENTSScheduleofEstimatedValueofCashCashEquivalentsMarketableSecuritiesandEquitySecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_2c717d0d-3d97-418b-bc2b-a8bf680c4e52" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_6197aaa5-a155-49bd-a7bb-9b25d6d77504" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_2c717d0d-3d97-418b-bc2b-a8bf680c4e52" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_6197aaa5-a155-49bd-a7bb-9b25d6d77504" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_e4792dc7-b938-4ed7-89b7-0acea609b866" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_2c717d0d-3d97-418b-bc2b-a8bf680c4e52" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_e4792dc7-b938-4ed7-89b7-0acea609b866" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_05bc0cef-234c-4599-b014-03416cacccab" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_2c717d0d-3d97-418b-bc2b-a8bf680c4e52" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_05bc0cef-234c-4599-b014-03416cacccab" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/BALANCESHEETACCOUNTDETAILScheduleofInventoryDetails" xlink:type="simple" xlink:href="tars-20250630.xsd#BALANCESHEETACCOUNTDETAILScheduleofInventoryDetails"/>
  <link:calculationLink xlink:role="http://tarsusrx.com/role/BALANCESHEETACCOUNTDETAILScheduleofInventoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNoncurrent_e5cbe6b3-2c93-4c73-b94d-e325bccbe926" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_InventoryRawMaterialsNoncurrentNetOfReserves_f6702e0f-a52a-40eb-8830-853ad10d1d20" xlink:href="tars-20250630.xsd#tars_InventoryRawMaterialsNoncurrentNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNoncurrent_e5cbe6b3-2c93-4c73-b94d-e325bccbe926" xlink:to="loc_tars_InventoryRawMaterialsNoncurrentNetOfReserves_f6702e0f-a52a-40eb-8830-853ad10d1d20" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_InventoryCurrentAndNoncurrentNet_12f1ba8c-9524-4c72-90ba-c7f5a1e55c7d" xlink:href="tars-20250630.xsd#tars_InventoryCurrentAndNoncurrentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_94ff3dec-384c-4ce9-9090-46cdfed2dd7e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_tars_InventoryCurrentAndNoncurrentNet_12f1ba8c-9524-4c72-90ba-c7f5a1e55c7d" xlink:to="loc_us-gaap_InventoryNet_94ff3dec-384c-4ce9-9090-46cdfed2dd7e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNoncurrent_b885f341-3601-4f92-8122-2334f2a170a8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_tars_InventoryCurrentAndNoncurrentNet_12f1ba8c-9524-4c72-90ba-c7f5a1e55c7d" xlink:to="loc_us-gaap_InventoryNoncurrent_b885f341-3601-4f92-8122-2334f2a170a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_b4d1ef02-bd43-41dd-ab7d-0dff5e39e920" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_587a2942-b39f-41a0-8bd1-e7bc15d934e5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_b4d1ef02-bd43-41dd-ab7d-0dff5e39e920" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_587a2942-b39f-41a0-8bd1-e7bc15d934e5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_438a208d-16e5-46c3-87bf-7aa757f0d0a6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_b4d1ef02-bd43-41dd-ab7d-0dff5e39e920" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_438a208d-16e5-46c3-87bf-7aa757f0d0a6" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/BALANCESHEETACCOUNTDETAILScheduleofPropertyandEquipmentNetDetails" xlink:type="simple" xlink:href="tars-20250630.xsd#BALANCESHEETACCOUNTDETAILScheduleofPropertyandEquipmentNetDetails"/>
  <link:calculationLink xlink:role="http://tarsusrx.com/role/BALANCESHEETACCOUNTDETAILScheduleofPropertyandEquipmentNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_697c141d-4462-4cf1-85af-0f6132b6645a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_86801344-3b38-4388-8cc1-c62c16ba24d8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_697c141d-4462-4cf1-85af-0f6132b6645a" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_86801344-3b38-4388-8cc1-c62c16ba24d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_65f275cd-29cc-4391-8882-76d41191ab9c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_697c141d-4462-4cf1-85af-0f6132b6645a" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_65f275cd-29cc-4391-8882-76d41191ab9c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/BALANCESHEETACCOUNTDETAILScheduleofIntangibleAssetsNetDetails" xlink:type="simple" xlink:href="tars-20250630.xsd#BALANCESHEETACCOUNTDETAILScheduleofIntangibleAssetsNetDetails"/>
  <link:calculationLink xlink:role="http://tarsusrx.com/role/BALANCESHEETACCOUNTDETAILScheduleofIntangibleAssetsNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_a779cb8f-3ebf-4cca-a882-675608969f51" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_ac721c92-e398-4c6f-83fc-e35db7c02ac6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_a779cb8f-3ebf-4cca-a882-675608969f51" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_ac721c92-e398-4c6f-83fc-e35db7c02ac6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_de041d1b-6922-434a-b3b3-3f6051f244b2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IntangibleAssetsGrossExcludingGoodwill"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_a779cb8f-3ebf-4cca-a882-675608969f51" xlink:to="loc_us-gaap_IntangibleAssetsGrossExcludingGoodwill_de041d1b-6922-434a-b3b3-3f6051f244b2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/BALANCESHEETACCOUNTDETAILScheduleofExpectedFutureAmortizationExpenseDetails" xlink:type="simple" xlink:href="tars-20250630.xsd#BALANCESHEETACCOUNTDETAILScheduleofExpectedFutureAmortizationExpenseDetails"/>
  <link:calculationLink xlink:role="http://tarsusrx.com/role/BALANCESHEETACCOUNTDETAILScheduleofExpectedFutureAmortizationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_459d9943-0de5-4d4d-9b9b-4efed40fcaac" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_282ba5cb-463f-4cd9-8727-638b575fa7bf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_459d9943-0de5-4d4d-9b9b-4efed40fcaac" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_282ba5cb-463f-4cd9-8727-638b575fa7bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_27c9dff1-f9f5-4df4-b5de-a3a9479c0fc5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_459d9943-0de5-4d4d-9b9b-4efed40fcaac" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_27c9dff1-f9f5-4df4-b5de-a3a9479c0fc5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_1ad0cf9a-c420-469b-9fc3-ff4574603354" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_459d9943-0de5-4d4d-9b9b-4efed40fcaac" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_1ad0cf9a-c420-469b-9fc3-ff4574603354" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_16ced505-5efe-4a75-80f1-11fda149fec4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_459d9943-0de5-4d4d-9b9b-4efed40fcaac" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_16ced505-5efe-4a75-80f1-11fda149fec4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour_050c96c6-0cf0-434c-b25e-90ed3bfafe8c" xlink:href="tars-20250630.xsd#tars_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_459d9943-0de5-4d4d-9b9b-4efed40fcaac" xlink:to="loc_tars_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour_050c96c6-0cf0-434c-b25e-90ed3bfafe8c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_46d34577-a910-447e-8425-7e33684cad59" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_459d9943-0de5-4d4d-9b9b-4efed40fcaac" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_46d34577-a910-447e-8425-7e33684cad59" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/BALANCESHEETACCOUNTDETAILScheduleofAccountsPayableandOtherAccruedLiabilitiesDetails" xlink:type="simple" xlink:href="tars-20250630.xsd#BALANCESHEETACCOUNTDETAILScheduleofAccountsPayableandOtherAccruedLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://tarsusrx.com/role/BALANCESHEETACCOUNTDETAILScheduleofAccountsPayableandOtherAccruedLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent_c9ccbb0d-15a0-4e0d-a310-b07f9d8fe38b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_288634aa-942a-4268-8b29-44c98a77a8ab" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent_c9ccbb0d-15a0-4e0d-a310-b07f9d8fe38b" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_288634aa-942a-4268-8b29-44c98a77a8ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableTradeCurrent_f13fd72b-c09e-40d9-9245-e9a98affd5e5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsPayableTradeCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent_c9ccbb0d-15a0-4e0d-a310-b07f9d8fe38b" xlink:to="loc_us-gaap_AccountsPayableTradeCurrent_f13fd72b-c09e-40d9-9245-e9a98affd5e5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_AccruedRoyaltyPayableCurrent_efbd189a-e387-4603-8287-d18544659b4d" xlink:href="tars-20250630.xsd#tars_AccruedRoyaltyPayableCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent_c9ccbb0d-15a0-4e0d-a310-b07f9d8fe38b" xlink:to="loc_tars_AccruedRoyaltyPayableCurrent_efbd189a-e387-4603-8287-d18544659b4d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedSalesCommissionCurrent_ba4669fe-9fbe-4866-93c5-1c013611f7f6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedSalesCommissionCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent_c9ccbb0d-15a0-4e0d-a310-b07f9d8fe38b" xlink:to="loc_us-gaap_AccruedSalesCommissionCurrent_ba4669fe-9fbe-4866-93c5-1c013611f7f6" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/STOCKBASEDCOMPENSATIONScheduleofTotalSharesReservedForFutureIssuanceDetails" xlink:type="simple" xlink:href="tars-20250630.xsd#STOCKBASEDCOMPENSATIONScheduleofTotalSharesReservedForFutureIssuanceDetails"/>
  <link:calculationLink xlink:role="http://tarsusrx.com/role/STOCKBASEDCOMPENSATIONScheduleofTotalSharesReservedForFutureIssuanceDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_f10071dc-6089-44c6-9ffa-8e81208f8a65" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_4bf4586b-99c3-4dc1-8c24-b1cafd0d1536" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_f10071dc-6089-44c6-9ffa-8e81208f8a65" xlink:to="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_4bf4586b-99c3-4dc1-8c24-b1cafd0d1536" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_CommonStockCapitalSharesReservedForFutureIssuanceEffectOfRestrictedStockUnitsAvailableForFutureGrant_181a9596-0ce0-44c5-a6d2-f53afe92b79a" xlink:href="tars-20250630.xsd#tars_CommonStockCapitalSharesReservedForFutureIssuanceEffectOfRestrictedStockUnitsAvailableForFutureGrant"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_f10071dc-6089-44c6-9ffa-8e81208f8a65" xlink:to="loc_tars_CommonStockCapitalSharesReservedForFutureIssuanceEffectOfRestrictedStockUnitsAvailableForFutureGrant_181a9596-0ce0-44c5-a6d2-f53afe92b79a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_CommonStockCapitalSharesReservedForFutureIssuanceEffectOfStockAwardsAvailableForFutureGrant_492c4e15-ef21-4934-8c05-6dae63a224c1" xlink:href="tars-20250630.xsd#tars_CommonStockCapitalSharesReservedForFutureIssuanceEffectOfStockAwardsAvailableForFutureGrant"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_f10071dc-6089-44c6-9ffa-8e81208f8a65" xlink:to="loc_tars_CommonStockCapitalSharesReservedForFutureIssuanceEffectOfStockAwardsAvailableForFutureGrant_492c4e15-ef21-4934-8c05-6dae63a224c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_CommonStockCapitalSharesReservedForFutureIssuanceEmployeeStockPurchasePlan_1392e1da-6ce7-4bf9-9281-bf70ccc8b69a" xlink:href="tars-20250630.xsd#tars_CommonStockCapitalSharesReservedForFutureIssuanceEmployeeStockPurchasePlan"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_f10071dc-6089-44c6-9ffa-8e81208f8a65" xlink:to="loc_tars_CommonStockCapitalSharesReservedForFutureIssuanceEmployeeStockPurchasePlan_1392e1da-6ce7-4bf9-9281-bf70ccc8b69a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_CommonStockCapitalSharesReservedForFutureIssuanceEffectOfStockOptionsIssuedAndOutstanding_dc910298-bae5-40ba-a645-e6b6a27eb67d" xlink:href="tars-20250630.xsd#tars_CommonStockCapitalSharesReservedForFutureIssuanceEffectOfStockOptionsIssuedAndOutstanding"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_f10071dc-6089-44c6-9ffa-8e81208f8a65" xlink:to="loc_tars_CommonStockCapitalSharesReservedForFutureIssuanceEffectOfStockOptionsIssuedAndOutstanding_dc910298-bae5-40ba-a645-e6b6a27eb67d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_CommonStockCapitalSharesReservedForFutureIssuanceEffectOfPerformanceStockUnitsAvailableForFutureGrant_892b5a73-6142-4548-95a1-4f7a2518bb79" xlink:href="tars-20250630.xsd#tars_CommonStockCapitalSharesReservedForFutureIssuanceEffectOfPerformanceStockUnitsAvailableForFutureGrant"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_f10071dc-6089-44c6-9ffa-8e81208f8a65" xlink:to="loc_tars_CommonStockCapitalSharesReservedForFutureIssuanceEffectOfPerformanceStockUnitsAvailableForFutureGrant_892b5a73-6142-4548-95a1-4f7a2518bb79" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/SEGMENTREPORTINGScheduleofOperatingFinancialResultsofTherapeuticsSegmentDetails" xlink:type="simple" xlink:href="tars-20250630.xsd#SEGMENTREPORTINGScheduleofOperatingFinancialResultsofTherapeuticsSegmentDetails"/>
  <link:calculationLink xlink:role="http://tarsusrx.com/role/SEGMENTREPORTINGScheduleofOperatingFinancialResultsofTherapeuticsSegmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_65b9f4ec-f215-4b02-9cdd-dee2d9ff48ec" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostsAndExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_a8759999-d6e7-4f65-863f-da3b326e3ae9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_65b9f4ec-f215-4b02-9cdd-dee2d9ff48ec" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_a8759999-d6e7-4f65-863f-da3b326e3ae9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_a6790ce1-fc39-4a7f-bf9c-84c6e30816b6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_65b9f4ec-f215-4b02-9cdd-dee2d9ff48ec" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_a6790ce1-fc39-4a7f-bf9c-84c6e30816b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingAndMarketingExpense_d3deff37-9026-4e2b-be4a-8cd111ddfe7c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SellingAndMarketingExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_65b9f4ec-f215-4b02-9cdd-dee2d9ff48ec" xlink:to="loc_us-gaap_SellingAndMarketingExpense_d3deff37-9026-4e2b-be4a-8cd111ddfe7c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_065fa55f-a822-4dcf-8942-3381fd1abf8d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_65b9f4ec-f215-4b02-9cdd-dee2d9ff48ec" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_065fa55f-a822-4dcf-8942-3381fd1abf8d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/COMMITMENTSCONTINGENCIESScheduleofComponentsofLeaseCostDetails" xlink:type="simple" xlink:href="tars-20250630.xsd#COMMITMENTSCONTINGENCIESScheduleofComponentsofLeaseCostDetails"/>
  <link:calculationLink xlink:role="http://tarsusrx.com/role/COMMITMENTSCONTINGENCIESScheduleofComponentsofLeaseCostDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCost_9fb3b190-ad53-4100-abc1-d53e371a467f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LeaseCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableLeaseCost_3423f670-e9fb-48ad-9d3b-5d444c5cfbe1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_VariableLeaseCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_9fb3b190-ad53-4100-abc1-d53e371a467f" xlink:to="loc_us-gaap_VariableLeaseCost_3423f670-e9fb-48ad-9d3b-5d444c5cfbe1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseCost_2f64f3ae-69ae-493d-a99c-3d4ba47ed3ba" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_9fb3b190-ad53-4100-abc1-d53e371a467f" xlink:to="loc_us-gaap_OperatingLeaseCost_2f64f3ae-69ae-493d-a99c-3d4ba47ed3ba" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/COMMITMENTSCONTINGENCIESScheduleofFutureContractualLeasePaymentsDetails" xlink:type="simple" xlink:href="tars-20250630.xsd#COMMITMENTSCONTINGENCIESScheduleofFutureContractualLeasePaymentsDetails"/>
  <link:calculationLink xlink:role="http://tarsusrx.com/role/COMMITMENTSCONTINGENCIESScheduleofFutureContractualLeasePaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_88106353-6821-4598-92a0-1c0bb7e2d2e4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_b823d2d1-04cb-4095-9d27-a0208efa0fbd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_88106353-6821-4598-92a0-1c0bb7e2d2e4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_b823d2d1-04cb-4095-9d27-a0208efa0fbd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_LesseeOperatingLeaseLiabilityToBePaidAfterCurrentFiscalYear_501387d6-ee28-4d2c-b789-8b1fd537062d" xlink:href="tars-20250630.xsd#tars_LesseeOperatingLeaseLiabilityToBePaidAfterCurrentFiscalYear"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_88106353-6821-4598-92a0-1c0bb7e2d2e4" xlink:to="loc_tars_LesseeOperatingLeaseLiabilityToBePaidAfterCurrentFiscalYear_501387d6-ee28-4d2c-b789-8b1fd537062d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_5ab1a87b-c068-4b9f-85ca-50ddabebc61a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_039545ac-369d-46e2-8c90-3736f5e3b8ab" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_5ab1a87b-c068-4b9f-85ca-50ddabebc61a" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_039545ac-369d-46e2-8c90-3736f5e3b8ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_c3b7d544-14dd-4e3e-b0d5-30de8d925138" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_5ab1a87b-c068-4b9f-85ca-50ddabebc61a" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_c3b7d544-14dd-4e3e-b0d5-30de8d925138" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/COMMITMENTSCONTINGENCIESScheduleofFutureContractualLeasePaymentsDetails_1" xlink:type="simple" xlink:href="tars-20250630.xsd#COMMITMENTSCONTINGENCIESScheduleofFutureContractualLeasePaymentsDetails_1"/>
  <link:calculationLink xlink:role="http://tarsusrx.com/role/COMMITMENTSCONTINGENCIESScheduleofFutureContractualLeasePaymentsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_a86db59d-7081-4057-a581-3cba09d9c459" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_06a8f608-908f-47a4-baa9-578d683e3fdf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_a86db59d-7081-4057-a581-3cba09d9c459" xlink:to="loc_us-gaap_OperatingLeaseLiability_06a8f608-908f-47a4-baa9-578d683e3fdf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_05ba5bd4-6064-460d-9832-cb1e23d7a668" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_a86db59d-7081-4057-a581-3cba09d9c459" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_05ba5bd4-6064-460d-9832-cb1e23d7a668" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/CREDITFACILITYAGREEMENTSScheduleofInterestExpenseDetails" xlink:type="simple" xlink:href="tars-20250630.xsd#CREDITFACILITYAGREEMENTSScheduleofInterestExpenseDetails"/>
  <link:calculationLink xlink:role="http://tarsusrx.com/role/CREDITFACILITYAGREEMENTSScheduleofInterestExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDebt_88b2b0c8-25d5-43c6-a97b-78cd7466059a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDebtExcludingAmortization_9ac3fdf6-75c0-4121-b95d-32f6960f932a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseDebtExcludingAmortization"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpenseDebt_88b2b0c8-25d5-43c6-a97b-78cd7466059a" xlink:to="loc_us-gaap_InterestExpenseDebtExcludingAmortization_9ac3fdf6-75c0-4121-b95d-32f6960f932a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfDebtDiscountPremium_85981c40-9461-4a15-ab11-e78b35810515" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfDebtDiscountPremium"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpenseDebt_88b2b0c8-25d5-43c6-a97b-78cd7466059a" xlink:to="loc_us-gaap_AmortizationOfDebtDiscountPremium_85981c40-9461-4a15-ab11-e78b35810515" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_5536721f-64d0-44a4-b781-b9718c679d75" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestExpenseDebt_88b2b0c8-25d5-43c6-a97b-78cd7466059a" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_5536721f-64d0-44a4-b781-b9718c679d75" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/CREDITFACILITYAGREEMENTSScheduleofPrincipalBalanceofthe2024CreditFacilityDetails" xlink:type="simple" xlink:href="tars-20250630.xsd#CREDITFACILITYAGREEMENTSScheduleofPrincipalBalanceofthe2024CreditFacilityDetails"/>
  <link:calculationLink xlink:role="http://tarsusrx.com/role/CREDITFACILITYAGREEMENTSScheduleofPrincipalBalanceofthe2024CreditFacilityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_387caeff-e23d-4e0c-a09e-62666065cda5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedAmortizationDeferredFinanceCosts_ee1497dc-93f5-4c61-875e-36c4f3b0a961" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedAmortizationDeferredFinanceCosts"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_387caeff-e23d-4e0c-a09e-62666065cda5" xlink:to="loc_us-gaap_AccumulatedAmortizationDeferredFinanceCosts_ee1497dc-93f5-4c61-875e-36c4f3b0a961" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtIssuanceCostsLineOfCreditArrangementsNet_07e555b3-59d8-45b2-a2c5-f86d2d6a9853" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtIssuanceCostsLineOfCreditArrangementsNet"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_387caeff-e23d-4e0c-a09e-62666065cda5" xlink:to="loc_us-gaap_DebtIssuanceCostsLineOfCreditArrangementsNet_07e555b3-59d8-45b2-a2c5-f86d2d6a9853" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_ba67723e-0f4d-4f7c-bcba-3b295cc9cb55" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_387caeff-e23d-4e0c-a09e-62666065cda5" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_ba67723e-0f4d-4f7c-bcba-3b295cc9cb55" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
