<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:ca7f32f9-96f0-4012-b103-640291baf868,g:bdc42935-be5b-45d9-b6ab-be7c0c989c96-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://tarsusrx.com/role/Cover" xlink:type="simple" xlink:href="tars-20220930.xsd#Cover"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_e016af12-93cf-4580-bd9e-f049d9594dad" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_DocumentType_e016af12-93cf-4580-bd9e-f049d9594dad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentQuarterlyReport_b56795cb-7ef3-40d9-b60b-246f3559b692" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentQuarterlyReport"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_DocumentQuarterlyReport_b56795cb-7ef3-40d9-b60b-246f3559b692" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_04fde7ed-43d9-4e88-8586-911e59a6f1b2" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_DocumentPeriodEndDate_04fde7ed-43d9-4e88-8586-911e59a6f1b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport_d3760571-1f23-4d4b-9024-1e7e5a3d7577" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentTransitionReport"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_DocumentTransitionReport_d3760571-1f23-4d4b-9024-1e7e5a3d7577" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_073c9d11-d761-4fb2-baa5-2f722b218f9e" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_EntityFileNumber_073c9d11-d761-4fb2-baa5-2f722b218f9e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_db414cfd-2ba6-4d1e-91a5-0c867d52244a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_EntityRegistrantName_db414cfd-2ba6-4d1e-91a5-0c867d52244a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_ce278520-e2de-46ff-ab01-f70228ba2de2" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_EntityIncorporationStateCountryCode_ce278520-e2de-46ff-ab01-f70228ba2de2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_47479b35-53df-4895-ae88-65b38cf35d5b" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_EntityTaxIdentificationNumber_47479b35-53df-4895-ae88-65b38cf35d5b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_6a27272a-0039-4e42-a3e7-a0be78193893" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_EntityAddressAddressLine1_6a27272a-0039-4e42-a3e7-a0be78193893" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_7f574c55-a3af-4377-930f-65c56dd32ae0" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_EntityAddressCityOrTown_7f574c55-a3af-4377-930f-65c56dd32ae0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_e00e69e3-4b2a-42b8-9a83-e370bb1d3f02" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_EntityAddressStateOrProvince_e00e69e3-4b2a-42b8-9a83-e370bb1d3f02" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_e0a88354-a3b2-4585-8afa-7684fd7f7fab" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_EntityAddressPostalZipCode_e0a88354-a3b2-4585-8afa-7684fd7f7fab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_aa1d3640-205e-4be4-b474-8e220a6632fa" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_CityAreaCode_aa1d3640-205e-4be4-b474-8e220a6632fa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_ca65fc3f-0b06-4c17-9cb4-096f6212b21f" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_LocalPhoneNumber_ca65fc3f-0b06-4c17-9cb4-096f6212b21f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_66c8af90-6499-4c9d-9c87-bd7a27ef6ae7" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_Security12bTitle_66c8af90-6499-4c9d-9c87-bd7a27ef6ae7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_37c9da47-f336-4cb5-bf98-054a7dad7668" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_TradingSymbol_37c9da47-f336-4cb5-bf98-054a7dad7668" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_10f294bc-2d5d-4719-beef-a3a0c8f562e4" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_SecurityExchangeName_10f294bc-2d5d-4719-beef-a3a0c8f562e4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_a43149f0-2950-4fc5-8ecf-4f5b5311c395" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCurrentReportingStatus"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_EntityCurrentReportingStatus_a43149f0-2950-4fc5-8ecf-4f5b5311c395" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_993183ce-74f6-49b1-ac3c-9a8015aff47b" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityInteractiveDataCurrent"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_EntityInteractiveDataCurrent_993183ce-74f6-49b1-ac3c-9a8015aff47b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_f5451513-8dd5-4cea-bc34-052e4bd49f6a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFilerCategory"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_EntityFilerCategory_f5451513-8dd5-4cea-bc34-052e4bd49f6a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_52d6f6ab-61fa-43c4-9123-70a6410ea69d" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntitySmallBusiness"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_EntitySmallBusiness_52d6f6ab-61fa-43c4-9123-70a6410ea69d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_73351f4b-4114-4076-a968-b502e5c3bf41" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_EntityEmergingGrowthCompany_73351f4b-4114-4076-a968-b502e5c3bf41" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityExTransitionPeriod_334d8337-37ef-44db-a85a-e22c22653249" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityExTransitionPeriod"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_EntityExTransitionPeriod_334d8337-37ef-44db-a85a-e22c22653249" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_7ea881df-2c08-41c2-893d-ac2b5b417de2" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityShellCompany"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_EntityShellCompany_7ea881df-2c08-41c2-893d-ac2b5b417de2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_166bfa6e-1f3c-49fe-872b-cabf487eb32d" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:presentationArc order="25" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_166bfa6e-1f3c-49fe-872b-cabf487eb32d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_df6e62ee-9ebc-49a5-95c0-2915935d671c" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="26" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_AmendmentFlag_df6e62ee-9ebc-49a5-95c0-2915935d671c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_fba74a29-3435-46c3-8e0e-d7884b5b12db" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="27" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_EntityCentralIndexKey_fba74a29-3435-46c3-8e0e-d7884b5b12db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_a9001d15-e3ad-41d9-8cfd-0ef067e3b911" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:presentationArc order="28" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_CurrentFiscalYearEndDate_a9001d15-e3ad-41d9-8cfd-0ef067e3b911" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_8d939283-4e63-433e-a985-e194827cbbd4" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentFiscalYearFocus"/>
    <link:presentationArc order="29" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_DocumentFiscalYearFocus_8d939283-4e63-433e-a985-e194827cbbd4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_1ab60984-e7d8-466e-9e3f-99b54958bb1d" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_3920f3de-1224-49fc-8722-2b75937a4b80" xlink:to="loc_dei_DocumentFiscalPeriodFocus_1ab60984-e7d8-466e-9e3f-99b54958bb1d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/CondensedBalanceSheets" xlink:type="simple" xlink:href="tars-20220930.xsd#CondensedBalanceSheets"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/CondensedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_8519befd-e282-4c39-a4c6-59422290a445" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfFinancialPositionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract_bb69e538-2ce4-4956-8ab9-ef018bce0b37" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_8519befd-e282-4c39-a4c6-59422290a445" xlink:to="loc_us-gaap_AssetsAbstract_bb69e538-2ce4-4956-8ab9-ef018bce0b37" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrentAbstract_11496f1e-9e25-47a9-98a3-11149ccd2423" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrentAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_bb69e538-2ce4-4956-8ab9-ef018bce0b37" xlink:to="loc_us-gaap_AssetsCurrentAbstract_11496f1e-9e25-47a9-98a3-11149ccd2423" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_77c97ed9-ac43-4ab4-b021-fb858f204173" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_11496f1e-9e25-47a9-98a3-11149ccd2423" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_77c97ed9-ac43-4ab4-b021-fb858f204173" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesCurrent_a9ff6ee5-fe79-435a-9490-e74776501b7b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MarketableSecuritiesCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_11496f1e-9e25-47a9-98a3-11149ccd2423" xlink:to="loc_us-gaap_MarketableSecuritiesCurrent_a9ff6ee5-fe79-435a-9490-e74776501b7b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_d619aaec-21c2-4cd2-9692-f6e1f65330ba" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_11496f1e-9e25-47a9-98a3-11149ccd2423" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_d619aaec-21c2-4cd2-9692-f6e1f65330ba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherReceivablesNetCurrent_74ee72d6-82f3-46fd-a0c8-9f8a4773904b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherReceivablesNetCurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_11496f1e-9e25-47a9-98a3-11149ccd2423" xlink:to="loc_us-gaap_OtherReceivablesNetCurrent_74ee72d6-82f3-46fd-a0c8-9f8a4773904b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseCurrent_a032e12b-dcd5-4806-80b5-3b546141e3cd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrepaidExpenseCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_11496f1e-9e25-47a9-98a3-11149ccd2423" xlink:to="loc_us-gaap_PrepaidExpenseCurrent_a032e12b-dcd5-4806-80b5-3b546141e3cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_dc9de179-ca90-42d5-80a2-b4094560a1ae" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_11496f1e-9e25-47a9-98a3-11149ccd2423" xlink:to="loc_us-gaap_AssetsCurrent_dc9de179-ca90-42d5-80a2-b4094560a1ae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_a9d98abe-c15f-4ae2-99b6-8ee9c554c0c9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_bb69e538-2ce4-4956-8ab9-ef018bce0b37" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_a9d98abe-c15f-4ae2-99b6-8ee9c554c0c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_155d8be6-e40e-4bbe-b1fb-1c7b7eaea851" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_bb69e538-2ce4-4956-8ab9-ef018bce0b37" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_155d8be6-e40e-4bbe-b1fb-1c7b7eaea851" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermInvestments_ab7653a3-875c-4bf1-99a9-316cbe37ecf1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermInvestments"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_bb69e538-2ce4-4956-8ab9-ef018bce0b37" xlink:to="loc_us-gaap_LongTermInvestments_ab7653a3-875c-4bf1-99a9-316cbe37ecf1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_541f85a4-a0b6-4173-bdf4-b505f93350e7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_bb69e538-2ce4-4956-8ab9-ef018bce0b37" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_541f85a4-a0b6-4173-bdf4-b505f93350e7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_9481e17a-7200-48e5-a5e1-7cd56442d059" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Assets"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_bb69e538-2ce4-4956-8ab9-ef018bce0b37" xlink:to="loc_us-gaap_Assets_9481e17a-7200-48e5-a5e1-7cd56442d059" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_3f24156e-241e-4ca4-bb10-2ec7b102fee8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_8519befd-e282-4c39-a4c6-59422290a445" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_3f24156e-241e-4ca4-bb10-2ec7b102fee8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_fbbbb49a-4e94-432d-b306-3a25b1c523eb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrentAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_3f24156e-241e-4ca4-bb10-2ec7b102fee8" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_fbbbb49a-4e94-432d-b306-3a25b1c523eb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent_653c6f4b-5abd-4e34-aa92-937d93bc4e11" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_fbbbb49a-4e94-432d-b306-3a25b1c523eb" xlink:to="loc_us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent_653c6f4b-5abd-4e34-aa92-937d93bc4e11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_6677a147-d2b5-415e-b90a-e5152102cf32" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_fbbbb49a-4e94-432d-b306-3a25b1c523eb" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_6677a147-d2b5-415e-b90a-e5152102cf32" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_125bd46b-fd38-49a1-8322-7e939b665e1b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_fbbbb49a-4e94-432d-b306-3a25b1c523eb" xlink:to="loc_us-gaap_LiabilitiesCurrent_125bd46b-fd38-49a1-8322-7e939b665e1b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_3d4f6186-438a-4805-b332-1290bfd8f241" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_3f24156e-241e-4ca4-bb10-2ec7b102fee8" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_3d4f6186-438a-4805-b332-1290bfd8f241" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_dd5ed806-5529-4b0a-863b-43b701ec7ce2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_3f24156e-241e-4ca4-bb10-2ec7b102fee8" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_dd5ed806-5529-4b0a-863b-43b701ec7ce2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_8f273c4b-b483-48ae-9a78-8dc405197179" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_3f24156e-241e-4ca4-bb10-2ec7b102fee8" xlink:to="loc_us-gaap_Liabilities_8f273c4b-b483-48ae-9a78-8dc405197179" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_f2918cce-3abc-4ab7-820a-3be600beefed" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_3f24156e-241e-4ca4-bb10-2ec7b102fee8" xlink:to="loc_us-gaap_CommitmentsAndContingencies_f2918cce-3abc-4ab7-820a-3be600beefed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityAbstract_d4e4dc0b-e967-438d-a08f-d19adb4248ba" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityAbstract"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_3f24156e-241e-4ca4-bb10-2ec7b102fee8" xlink:to="loc_us-gaap_StockholdersEquityAbstract_d4e4dc0b-e967-438d-a08f-d19adb4248ba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_7acfd30b-9954-45f4-9b19-503aec47c649" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_d4e4dc0b-e967-438d-a08f-d19adb4248ba" xlink:to="loc_us-gaap_PreferredStockValue_7acfd30b-9954-45f4-9b19-503aec47c649" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_486b9e8d-5831-44e3-b41c-7571c51c3927" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockValue"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_d4e4dc0b-e967-438d-a08f-d19adb4248ba" xlink:to="loc_us-gaap_CommonStockValue_486b9e8d-5831-44e3-b41c-7571c51c3927" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_920b00bb-b9ec-4249-a08b-85889d88663c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_d4e4dc0b-e967-438d-a08f-d19adb4248ba" xlink:to="loc_us-gaap_AdditionalPaidInCapital_920b00bb-b9ec-4249-a08b-85889d88663c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_59a8b0f8-c2fd-4bbf-b08f-9108c0c40a71" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_d4e4dc0b-e967-438d-a08f-d19adb4248ba" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_59a8b0f8-c2fd-4bbf-b08f-9108c0c40a71" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_e36a9974-71df-4dbb-9054-900282d7ee27" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_d4e4dc0b-e967-438d-a08f-d19adb4248ba" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_e36a9974-71df-4dbb-9054-900282d7ee27" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_60685bdc-b727-4ce8-8ebb-66f010d984b5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_d4e4dc0b-e967-438d-a08f-d19adb4248ba" xlink:to="loc_us-gaap_StockholdersEquity_60685bdc-b727-4ce8-8ebb-66f010d984b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_61c8b5ee-3683-48b3-a0b9-796742b23138" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_3f24156e-241e-4ca4-bb10-2ec7b102fee8" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_61c8b5ee-3683-48b3-a0b9-796742b23138" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_ff68680b-5456-44f2-9e87-0f5af5d1904c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_8519befd-e282-4c39-a4c6-59422290a445" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_ff68680b-5456-44f2-9e87-0f5af5d1904c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/CondensedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="tars-20220930.xsd#CondensedBalanceSheetsParenthetical"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/CondensedBalanceSheetsParenthetical" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_ede86628-c39b-4823-aa19-badd2515c436" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfFinancialPositionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_259a2dc6-5e60-4c99-8b6c-6af4a99e60a5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockParOrStatedValuePerShare"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_ede86628-c39b-4823-aa19-badd2515c436" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_259a2dc6-5e60-4c99-8b6c-6af4a99e60a5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_3dfb42d0-0888-477e-a83e-d81d6c45ef85" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesAuthorized"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_ede86628-c39b-4823-aa19-badd2515c436" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_3dfb42d0-0888-477e-a83e-d81d6c45ef85" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesIssued_119466ab-adf8-4981-a898-de5a8d2ee64b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesIssued"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_ede86628-c39b-4823-aa19-badd2515c436" xlink:to="loc_us-gaap_PreferredStockSharesIssued_119466ab-adf8-4981-a898-de5a8d2ee64b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_bd3ae827-6638-4bb8-9e83-386f5cd611bb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesOutstanding"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_ede86628-c39b-4823-aa19-badd2515c436" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_bd3ae827-6638-4bb8-9e83-386f5cd611bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_33390ffd-fed6-45f0-a585-a9c730799ade" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_ede86628-c39b-4823-aa19-badd2515c436" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_33390ffd-fed6-45f0-a585-a9c730799ade" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_7d95baa3-3096-465f-b365-6085123285bb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_ede86628-c39b-4823-aa19-badd2515c436" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_7d95baa3-3096-465f-b365-6085123285bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_bf7c064d-31af-4bb8-90cd-5e7097cf4ddf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_ede86628-c39b-4823-aa19-badd2515c436" xlink:to="loc_us-gaap_CommonStockSharesIssued_bf7c064d-31af-4bb8-90cd-5e7097cf4ddf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_380afa35-e85e-467b-9f70-b9945b0169f8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_ede86628-c39b-4823-aa19-badd2515c436" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_380afa35-e85e-467b-9f70-b9945b0169f8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_CommonStockSharesSubjectToRepurchase_40d8aa11-b20e-466d-ac09-6b467d5b4a66" xlink:href="tars-20220930.xsd#tars_CommonStockSharesSubjectToRepurchase"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_ede86628-c39b-4823-aa19-badd2515c436" xlink:to="loc_tars_CommonStockSharesSubjectToRepurchase_40d8aa11-b20e-466d-ac09-6b467d5b4a66" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/CondensedStatementsofOperationsandComprehensiveLossIncome" xlink:type="simple" xlink:href="tars-20220930.xsd#CondensedStatementsofOperationsandComprehensiveLossIncome"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/CondensedStatementsofOperationsandComprehensiveLossIncome" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementAbstract_f3a664f8-9623-453f-8767-7d0dd1f37606" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_7390b73e-d812-42a2-b0b3-a1d9270d0430" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_f3a664f8-9623-453f-8767-7d0dd1f37606" xlink:to="loc_us-gaap_StatementTable_7390b73e-d812-42a2-b0b3-a1d9270d0430" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_b0a7733a-41fc-4b1c-a387-b3db3abb14c8" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_7390b73e-d812-42a2-b0b3-a1d9270d0430" xlink:to="loc_srt_ProductOrServiceAxis_b0a7733a-41fc-4b1c-a387-b3db3abb14c8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_0b836718-9bb0-4d79-a786-be398ae3f8e0" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_b0a7733a-41fc-4b1c-a387-b3db3abb14c8" xlink:to="loc_srt_ProductsAndServicesDomain_0b836718-9bb0-4d79-a786-be398ae3f8e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicenseAndServiceMember_c9923c13-d460-4216-bda6-70a2e00d85ca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LicenseAndServiceMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_0b836718-9bb0-4d79-a786-be398ae3f8e0" xlink:to="loc_us-gaap_LicenseAndServiceMember_c9923c13-d460-4216-bda6-70a2e00d85ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_CollaborationMember_5da8f8e1-0325-4e48-999d-1e2466c08008" xlink:href="tars-20220930.xsd#tars_CollaborationMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_0b836718-9bb0-4d79-a786-be398ae3f8e0" xlink:to="loc_tars_CollaborationMember_5da8f8e1-0325-4e48-999d-1e2466c08008" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_c0a47f02-f90a-46bb-a6a9-98a56ff314a6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_7390b73e-d812-42a2-b0b3-a1d9270d0430" xlink:to="loc_us-gaap_StatementLineItems_c0a47f02-f90a-46bb-a6a9-98a56ff314a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract_11d57405-9d25-4ef2-bb70-2ca94aae4ebc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenuesAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_c0a47f02-f90a-46bb-a6a9-98a56ff314a6" xlink:to="loc_us-gaap_RevenuesAbstract_11d57405-9d25-4ef2-bb70-2ca94aae4ebc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_d9e1e14d-98db-4523-bc6b-eb637ea0e01b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Revenues"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesAbstract_11d57405-9d25-4ef2-bb70-2ca94aae4ebc" xlink:to="loc_us-gaap_Revenues_d9e1e14d-98db-4523-bc6b-eb637ea0e01b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpensesAbstract_667ba53e-8648-4f20-91c1-4519a11a3366" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingExpensesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_c0a47f02-f90a-46bb-a6a9-98a56ff314a6" xlink:to="loc_us-gaap_OperatingExpensesAbstract_667ba53e-8648-4f20-91c1-4519a11a3366" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_3da87695-55aa-4775-b24d-b572dd3580e2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingExpensesAbstract_667ba53e-8648-4f20-91c1-4519a11a3366" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_3da87695-55aa-4775-b24d-b572dd3580e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_3840f434-fc74-492f-8d7e-f495f83bf259" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingExpensesAbstract_667ba53e-8648-4f20-91c1-4519a11a3366" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_3840f434-fc74-492f-8d7e-f495f83bf259" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_d30b2efe-bfaf-494e-a30f-209793fe7f7b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingExpensesAbstract_667ba53e-8648-4f20-91c1-4519a11a3366" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_d30b2efe-bfaf-494e-a30f-209793fe7f7b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_607c362f-a6f6-44a3-93df-753aba1fed5b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostsAndExpenses"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingExpensesAbstract_667ba53e-8648-4f20-91c1-4519a11a3366" xlink:to="loc_us-gaap_CostsAndExpenses_607c362f-a6f6-44a3-93df-753aba1fed5b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_00f2d780-4272-4af2-9965-e042e1f09c25" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_c0a47f02-f90a-46bb-a6a9-98a56ff314a6" xlink:to="loc_us-gaap_OperatingIncomeLoss_00f2d780-4272-4af2-9965-e042e1f09c25" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseAbstract_59a384ae-b1a8-45fc-a0cb-8666ea9572d7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NonoperatingIncomeExpenseAbstract"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_c0a47f02-f90a-46bb-a6a9-98a56ff314a6" xlink:to="loc_us-gaap_NonoperatingIncomeExpenseAbstract_59a384ae-b1a8-45fc-a0cb-8666ea9572d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeOther_5e9d7f96-c3ce-45ef-8b67-2d1c6d3a994b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestIncomeOther"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_59a384ae-b1a8-45fc-a0cb-8666ea9572d7" xlink:to="loc_us-gaap_InterestIncomeOther_5e9d7f96-c3ce-45ef-8b67-2d1c6d3a994b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_e941d49e-85ff-4b40-96c1-657f290e32c3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpense"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_59a384ae-b1a8-45fc-a0cb-8666ea9572d7" xlink:to="loc_us-gaap_InterestExpense_e941d49e-85ff-4b40-96c1-657f290e32c3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_e64fb0ce-4708-4b8e-83ef-2551f70bb1f1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_59a384ae-b1a8-45fc-a0cb-8666ea9572d7" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_e64fb0ce-4708-4b8e-83ef-2551f70bb1f1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss_6fc6518f-9cdb-4e1d-acb8-5217794cd0dc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_59a384ae-b1a8-45fc-a0cb-8666ea9572d7" xlink:to="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss_6fc6518f-9cdb-4e1d-acb8-5217794cd0dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_991afa23-6a5d-496d-b222-e3e3c672f8f3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_59a384ae-b1a8-45fc-a0cb-8666ea9572d7" xlink:to="loc_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_991afa23-6a5d-496d-b222-e3e3c672f8f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_9bf285f2-ba94-4cf4-9537-fb58632c0260" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_59a384ae-b1a8-45fc-a0cb-8666ea9572d7" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_9bf285f2-ba94-4cf4-9537-fb58632c0260" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_ec9c8f51-8feb-46e7-9129-b2168470970b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_c0a47f02-f90a-46bb-a6a9-98a56ff314a6" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_ec9c8f51-8feb-46e7-9129-b2168470970b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_9dd589f2-bd91-4c18-8452-51984474b72d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_c0a47f02-f90a-46bb-a6a9-98a56ff314a6" xlink:to="loc_us-gaap_NetIncomeLoss_9dd589f2-bd91-4c18-8452-51984474b72d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_e6b488b6-55b7-4e1a-b106-d680ddacb670" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_c0a47f02-f90a-46bb-a6a9-98a56ff314a6" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_e6b488b6-55b7-4e1a-b106-d680ddacb670" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_ce86c176-880d-4580-8468-8446d22228c9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_e6b488b6-55b7-4e1a-b106-d680ddacb670" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_ce86c176-880d-4580-8468-8446d22228c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_690f4176-d3ff-43d0-a93c-eb3b27e1b63a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract_e6b488b6-55b7-4e1a-b106-d680ddacb670" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_690f4176-d3ff-43d0-a93c-eb3b27e1b63a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_29fb4298-54af-4de3-b26a-e343ae2a1242" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_c0a47f02-f90a-46bb-a6a9-98a56ff314a6" xlink:to="loc_us-gaap_EarningsPerShareAbstract_29fb4298-54af-4de3-b26a-e343ae2a1242" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_4cec9da3-f793-4779-ba8c-433d60c623e1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_29fb4298-54af-4de3-b26a-e343ae2a1242" xlink:to="loc_us-gaap_EarningsPerShareBasic_4cec9da3-f793-4779-ba8c-433d60c623e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_9dbfbf0f-e027-4b1f-8a0c-24cbf2d665bd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_29fb4298-54af-4de3-b26a-e343ae2a1242" xlink:to="loc_us-gaap_EarningsPerShareDiluted_9dbfbf0f-e027-4b1f-8a0c-24cbf2d665bd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_1c491f41-2047-4829-a987-6976d1a63ee1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_c0a47f02-f90a-46bb-a6a9-98a56ff314a6" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_1c491f41-2047-4829-a987-6976d1a63ee1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_d206115a-9ec3-45e3-af2a-91c14662b398" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_1c491f41-2047-4829-a987-6976d1a63ee1" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_d206115a-9ec3-45e3-af2a-91c14662b398" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_12599893-e8c4-4fcd-870f-d756605a092b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_1c491f41-2047-4829-a987-6976d1a63ee1" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_12599893-e8c4-4fcd-870f-d756605a092b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/CondensedStatementsofStockholdersEquity" xlink:type="simple" xlink:href="tars-20220930.xsd#CondensedStatementsofStockholdersEquity"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/CondensedStatementsofStockholdersEquity" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_9cde91d4-b9a0-4486-9491-1b24f71314dd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfStockholdersEquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_ba856e6c-1f30-408a-9f2e-8f552c425042" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_9cde91d4-b9a0-4486-9491-1b24f71314dd" xlink:to="loc_us-gaap_StatementTable_ba856e6c-1f30-408a-9f2e-8f552c425042" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_2034165d-f390-400c-957e-b1899d3909d9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_ba856e6c-1f30-408a-9f2e-8f552c425042" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_2034165d-f390-400c-957e-b1899d3909d9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_c185bc4d-2026-439d-a151-dcc1885b383d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_2034165d-f390-400c-957e-b1899d3909d9" xlink:to="loc_us-gaap_EquityComponentDomain_c185bc4d-2026-439d-a151-dcc1885b383d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_8bf73926-ff17-4ddc-9c4f-83a77233f5af" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_c185bc4d-2026-439d-a151-dcc1885b383d" xlink:to="loc_us-gaap_CommonStockMember_8bf73926-ff17-4ddc-9c4f-83a77233f5af" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_882a50d7-a86f-478b-86b8-43ae3b08e251" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_c185bc4d-2026-439d-a151-dcc1885b383d" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_882a50d7-a86f-478b-86b8-43ae3b08e251" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_1df41396-7d0f-4338-90da-bac49597b060" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_c185bc4d-2026-439d-a151-dcc1885b383d" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_1df41396-7d0f-4338-90da-bac49597b060" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_be8563d6-080e-47fb-9590-336251029753" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_c185bc4d-2026-439d-a151-dcc1885b383d" xlink:to="loc_us-gaap_RetainedEarningsMember_be8563d6-080e-47fb-9590-336251029753" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_0bcdb887-3509-4e6f-9880-15082c2f3da5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_ba856e6c-1f30-408a-9f2e-8f552c425042" xlink:to="loc_us-gaap_StatementLineItems_0bcdb887-3509-4e6f-9880-15082c2f3da5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_3b882bca-0d14-4799-9371-2ae203e9a8e6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInTemporaryEquityRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_0bcdb887-3509-4e6f-9880-15082c2f3da5" xlink:to="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_3b882bca-0d14-4799-9371-2ae203e9a8e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquitySharesOutstanding_a0842bdb-67fb-45ad-953a-47fb5202084d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TemporaryEquitySharesOutstanding"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_3b882bca-0d14-4799-9371-2ae203e9a8e6" xlink:to="loc_us-gaap_TemporaryEquitySharesOutstanding_a0842bdb-67fb-45ad-953a-47fb5202084d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquitySharesOutstanding_be93476e-d1d5-471b-8ad5-9ddde5d60a36" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TemporaryEquitySharesOutstanding"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_3b882bca-0d14-4799-9371-2ae203e9a8e6" xlink:to="loc_us-gaap_TemporaryEquitySharesOutstanding_be93476e-d1d5-471b-8ad5-9ddde5d60a36" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquityCarryingAmountAttributableToParent_11ea1507-ebae-40dd-81ce-46e8c8d28b40" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TemporaryEquityCarryingAmountAttributableToParent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_3b882bca-0d14-4799-9371-2ae203e9a8e6" xlink:to="loc_us-gaap_TemporaryEquityCarryingAmountAttributableToParent_11ea1507-ebae-40dd-81ce-46e8c8d28b40" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquityCarryingAmountAttributableToParent_d90f4b47-9397-4bd1-9770-8c0bd06cb7ff" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TemporaryEquityCarryingAmountAttributableToParent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_3b882bca-0d14-4799-9371-2ae203e9a8e6" xlink:to="loc_us-gaap_TemporaryEquityCarryingAmountAttributableToParent_d90f4b47-9397-4bd1-9770-8c0bd06cb7ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_795617c5-ecc9-4b70-8488-85ee969a0d86" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_0bcdb887-3509-4e6f-9880-15082c2f3da5" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_795617c5-ecc9-4b70-8488-85ee969a0d86" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_e8f26be7-57d0-48c5-9d07-2047ea76da35" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_795617c5-ecc9-4b70-8488-85ee969a0d86" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_e8f26be7-57d0-48c5-9d07-2047ea76da35" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_7e7b5838-575a-485e-9a71-4de8692543cf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_795617c5-ecc9-4b70-8488-85ee969a0d86" xlink:to="loc_us-gaap_StockholdersEquity_7e7b5838-575a-485e-9a71-4de8692543cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_062bf76c-0d88-4c1b-8f26-04b1a0a11506" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_795617c5-ecc9-4b70-8488-85ee969a0d86" xlink:to="loc_us-gaap_NetIncomeLoss_062bf76c-0d88-4c1b-8f26-04b1a0a11506" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_b5eb9e5b-4999-4cb1-8ac3-0b41cadf703e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_795617c5-ecc9-4b70-8488-85ee969a0d86" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_b5eb9e5b-4999-4cb1-8ac3-0b41cadf703e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_a7c6261e-c183-4b70-8c00-9d2d9b095e30" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_795617c5-ecc9-4b70-8488-85ee969a0d86" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_a7c6261e-c183-4b70-8c00-9d2d9b095e30" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_6a837425-4bb0-4e8e-b4f9-81d3c5438541" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_795617c5-ecc9-4b70-8488-85ee969a0d86" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_6a837425-4bb0-4e8e-b4f9-81d3c5438541" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCosts_83da9d8d-0142-4eea-9e70-c36efc960a48" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCosts"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_795617c5-ecc9-4b70-8488-85ee969a0d86" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCosts_83da9d8d-0142-4eea-9e70-c36efc960a48" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesUnrealizedGainLoss_0f8a1908-18ff-4cf6-b4fb-14d5ae8c2aed" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MarketableSecuritiesUnrealizedGainLoss"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_795617c5-ecc9-4b70-8488-85ee969a0d86" xlink:to="loc_us-gaap_MarketableSecuritiesUnrealizedGainLoss_0f8a1908-18ff-4cf6-b4fb-14d5ae8c2aed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardGross_39b01276-6c30-40ee-bf0a-d470a3128e91" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardGross"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_795617c5-ecc9-4b70-8488-85ee969a0d86" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardGross_39b01276-6c30-40ee-bf0a-d470a3128e91" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_StockIssuedDuringPeriodSharesLapseOfRepurchaseRights_a0c967d6-4173-475b-a734-e8f94800f589" xlink:href="tars-20220930.xsd#tars_StockIssuedDuringPeriodSharesLapseOfRepurchaseRights"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_795617c5-ecc9-4b70-8488-85ee969a0d86" xlink:to="loc_tars_StockIssuedDuringPeriodSharesLapseOfRepurchaseRights_a0c967d6-4173-475b-a734-e8f94800f589" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_StockIssuedDuringPeriodValueLapseOfRepurchaseRights_23fda813-6bf2-4c89-bb65-d22e740ab30c" xlink:href="tars-20220930.xsd#tars_StockIssuedDuringPeriodValueLapseOfRepurchaseRights"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_795617c5-ecc9-4b70-8488-85ee969a0d86" xlink:to="loc_tars_StockIssuedDuringPeriodValueLapseOfRepurchaseRights_23fda813-6bf2-4c89-bb65-d22e740ab30c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_e71957c6-6c35-48f4-8dfb-5bd812b92236" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_795617c5-ecc9-4b70-8488-85ee969a0d86" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_e71957c6-6c35-48f4-8dfb-5bd812b92236" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_c61d1d24-7181-41f7-9ec7-4c21c3f07f8e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_795617c5-ecc9-4b70-8488-85ee969a0d86" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_c61d1d24-7181-41f7-9ec7-4c21c3f07f8e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_f363f969-9a9d-4dd1-a081-94c4e4cd6a99" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_795617c5-ecc9-4b70-8488-85ee969a0d86" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_f363f969-9a9d-4dd1-a081-94c4e4cd6a99" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_9b9627bb-2e48-476b-bcb8-b11923c08d1c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_795617c5-ecc9-4b70-8488-85ee969a0d86" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_9b9627bb-2e48-476b-bcb8-b11923c08d1c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesIssuedForServices_c1b180cc-598f-4612-9c61-e10a92babeb1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesIssuedForServices"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_795617c5-ecc9-4b70-8488-85ee969a0d86" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesIssuedForServices_c1b180cc-598f-4612-9c61-e10a92babeb1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueIssuedForServices_1ea01253-bcf1-452a-8819-f3ba86c95825" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueIssuedForServices"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_795617c5-ecc9-4b70-8488-85ee969a0d86" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueIssuedForServices_1ea01253-bcf1-452a-8819-f3ba86c95825" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_05be2d04-2f1e-4aec-a96d-937bad453481" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_795617c5-ecc9-4b70-8488-85ee969a0d86" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_05be2d04-2f1e-4aec-a96d-937bad453481" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_4e814b77-91df-4147-950d-457d28eb656c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_795617c5-ecc9-4b70-8488-85ee969a0d86" xlink:to="loc_us-gaap_StockholdersEquity_4e814b77-91df-4147-950d-457d28eb656c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/CondensedStatementsofCashFlows" xlink:type="simple" xlink:href="tars-20220930.xsd#CondensedStatementsofCashFlows"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/CondensedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_a898f4b9-9e65-4c14-9ca6-ea7b02cec122" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfCashFlowsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_29f4a6e2-dc05-4cf4-9c03-b6abdefbdab1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_a898f4b9-9e65-4c14-9ca6-ea7b02cec122" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_29f4a6e2-dc05-4cf4-9c03-b6abdefbdab1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_baf830c0-ef0f-4c3a-acdc-06f116fce06f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_29f4a6e2-dc05-4cf4-9c03-b6abdefbdab1" xlink:to="loc_us-gaap_NetIncomeLoss_baf830c0-ef0f-4c3a-acdc-06f116fce06f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_e6656d67-1352-4ee6-89ce-12e46c7e0a7c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_29f4a6e2-dc05-4cf4-9c03-b6abdefbdab1" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_e6656d67-1352-4ee6-89ce-12e46c7e0a7c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherDepreciationAndAmortization_e7da7971-0a3e-4a5c-93f5-bd7eea7ac2ff" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherDepreciationAndAmortization"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_e6656d67-1352-4ee6-89ce-12e46c7e0a7c" xlink:to="loc_us-gaap_OtherDepreciationAndAmortization_e7da7971-0a3e-4a5c-93f5-bd7eea7ac2ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_fc2f81e7-9f97-485b-aa54-3d65c2e35fc5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfFinancingCostsAndDiscounts"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_e6656d67-1352-4ee6-89ce-12e46c7e0a7c" xlink:to="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_fc2f81e7-9f97-485b-aa54-3d65c2e35fc5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_777a6ce8-cca8-4f19-9f46-23cf10a2f037" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensation"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_e6656d67-1352-4ee6-89ce-12e46c7e0a7c" xlink:to="loc_us-gaap_ShareBasedCompensation_777a6ce8-cca8-4f19-9f46-23cf10a2f037" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_OperatingLeaseNoncashExpense_b204fc8b-1eea-48a1-8b90-f438c85328ef" xlink:href="tars-20220930.xsd#tars_OperatingLeaseNoncashExpense"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_e6656d67-1352-4ee6-89ce-12e46c7e0a7c" xlink:to="loc_tars_OperatingLeaseNoncashExpense_b204fc8b-1eea-48a1-8b90-f438c85328ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_096f619e-d170-4cec-aed5-16d3f964410a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainLossOnSaleOfPropertyPlantEquipment"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_e6656d67-1352-4ee6-89ce-12e46c7e0a7c" xlink:to="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_096f619e-d170-4cec-aed5-16d3f964410a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnTerminationOfLease_785e617a-06d3-4aca-ba0c-8453507e4ba3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainLossOnTerminationOfLease"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_e6656d67-1352-4ee6-89ce-12e46c7e0a7c" xlink:to="loc_us-gaap_GainLossOnTerminationOfLease_785e617a-06d3-4aca-ba0c-8453507e4ba3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss_e5851f9f-dc3c-4b55-b058-a2c4023f0251" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_e6656d67-1352-4ee6-89ce-12e46c7e0a7c" xlink:to="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss_e5851f9f-dc3c-4b55-b058-a2c4023f0251" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_c1a092c1-4c23-43c7-acae-74e77dd4385f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_e6656d67-1352-4ee6-89ce-12e46c7e0a7c" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_c1a092c1-4c23-43c7-acae-74e77dd4385f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_68a0af4c-46a6-48c7-89f6-6151f756bbf0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_e6656d67-1352-4ee6-89ce-12e46c7e0a7c" xlink:to="loc_us-gaap_EmbeddedDerivativeGainLossOnEmbeddedDerivativeNet_68a0af4c-46a6-48c7-89f6-6151f756bbf0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossUnrealized_af535d05-6f5b-414a-8b6c-9c3d760301d5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ForeignCurrencyTransactionGainLossUnrealized"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_e6656d67-1352-4ee6-89ce-12e46c7e0a7c" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossUnrealized_af535d05-6f5b-414a-8b6c-9c3d760301d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IssuanceOfStockAndWarrantsForServicesOrClaims_7c0adb00-6e2e-4142-aa43-3d1d16f36969" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IssuanceOfStockAndWarrantsForServicesOrClaims"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_e6656d67-1352-4ee6-89ce-12e46c7e0a7c" xlink:to="loc_us-gaap_IssuanceOfStockAndWarrantsForServicesOrClaims_7c0adb00-6e2e-4142-aa43-3d1d16f36969" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_8a525265-8230-48a4-a178-04fb898bfc76" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_e6656d67-1352-4ee6-89ce-12e46c7e0a7c" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_8a525265-8230-48a4-a178-04fb898bfc76" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_3841cd59-5ec5-4734-b3a8-62398086a184" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_8a525265-8230-48a4-a178-04fb898bfc76" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_3841cd59-5ec5-4734-b3a8-62398086a184" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherReceivables_3ad74e3d-066e-4f59-9592-d8ee359b495f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOtherReceivables"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_8a525265-8230-48a4-a178-04fb898bfc76" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherReceivables_3ad74e3d-066e-4f59-9592-d8ee359b495f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidExpense_881a9d78-5b71-4924-83ec-6e6aea8ee6b5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInPrepaidExpense"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_8a525265-8230-48a4-a178-04fb898bfc76" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidExpense_881a9d78-5b71-4924-83ec-6e6aea8ee6b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_f9405595-2123-4714-9bc7-c2b819004f79" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentAssets"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_8a525265-8230-48a4-a178-04fb898bfc76" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_f9405595-2123-4714-9bc7-c2b819004f79" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities_af72ed13-2a2b-4b4b-822d-5330483e33d8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_8a525265-8230-48a4-a178-04fb898bfc76" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities_af72ed13-2a2b-4b4b-822d-5330483e33d8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities_fa2e9064-b9b7-45e5-8c21-b71ac3bd8225" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_8a525265-8230-48a4-a178-04fb898bfc76" xlink:to="loc_us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities_fa2e9064-b9b7-45e5-8c21-b71ac3bd8225" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_70143e07-e4ce-475e-8b64-2f4257aea5af" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_8a525265-8230-48a4-a178-04fb898bfc76" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_70143e07-e4ce-475e-8b64-2f4257aea5af" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e63d624a-c224-48e4-8f1b-ef91156a4068" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_29f4a6e2-dc05-4cf4-9c03-b6abdefbdab1" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e63d624a-c224-48e4-8f1b-ef91156a4068" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_aea0ee28-3a52-42dd-8946-b68b4b0264bf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_a898f4b9-9e65-4c14-9ca6-ea7b02cec122" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_aea0ee28-3a52-42dd-8946-b68b4b0264bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_85b8e7aa-800b-4244-9af9-711945514e50" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_aea0ee28-3a52-42dd-8946-b68b4b0264bf" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_85b8e7aa-800b-4244-9af9-711945514e50" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_a684b31c-c34c-4307-884b-54bbcf6917a8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_aea0ee28-3a52-42dd-8946-b68b4b0264bf" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_a684b31c-c34c-4307-884b-54bbcf6917a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d94cbf7d-9032-4691-9248-79178370be01" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_aea0ee28-3a52-42dd-8946-b68b4b0264bf" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_d94cbf7d-9032-4691-9248-79178370be01" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_3cd9be90-7fe6-4445-874c-6ab004bd4806" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_a898f4b9-9e65-4c14-9ca6-ea7b02cec122" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_3cd9be90-7fe6-4445-874c-6ab004bd4806" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_ce210c95-e7f1-45e1-be8f-48435eebd9f1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_3cd9be90-7fe6-4445-874c-6ab004bd4806" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_ce210c95-e7f1-45e1-be8f-48435eebd9f1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockPlans_f927d6f4-183e-464d-bef4-944cb024e60b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromStockPlans"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_3cd9be90-7fe6-4445-874c-6ab004bd4806" xlink:to="loc_us-gaap_ProceedsFromStockPlans_f927d6f4-183e-464d-bef4-944cb024e60b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_ProceedsFromEarlyExerciseOfStockOptions_2fff5b0b-1e0c-4f94-974e-ad4b7dde5f82" xlink:href="tars-20220930.xsd#tars_ProceedsFromEarlyExerciseOfStockOptions"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_3cd9be90-7fe6-4445-874c-6ab004bd4806" xlink:to="loc_tars_ProceedsFromEarlyExerciseOfStockOptions_2fff5b0b-1e0c-4f94-974e-ad4b7dde5f82" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_PaymentsOfDeferredStockIssuanceCosts_6c61a873-fd95-4c17-ab45-c97e96a28a0a" xlink:href="tars-20220930.xsd#tars_PaymentsOfDeferredStockIssuanceCosts"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_3cd9be90-7fe6-4445-874c-6ab004bd4806" xlink:to="loc_tars_PaymentsOfDeferredStockIssuanceCosts_6c61a873-fd95-4c17-ab45-c97e96a28a0a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_459e0fee-c7d6-4922-ae6f-c194eee880ef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_3cd9be90-7fe6-4445-874c-6ab004bd4806" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_459e0fee-c7d6-4922-ae6f-c194eee880ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_8a112208-70fc-4f98-97c8-8871a42dc5b5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsOfDebtIssuanceCosts"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_3cd9be90-7fe6-4445-874c-6ab004bd4806" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_8a112208-70fc-4f98-97c8-8871a42dc5b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d54e29ac-68d4-4f95-81e2-26059d072f9f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_3cd9be90-7fe6-4445-874c-6ab004bd4806" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d54e29ac-68d4-4f95-81e2-26059d072f9f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_9486296a-bf66-4773-a35c-beac9cc0c701" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_a898f4b9-9e65-4c14-9ca6-ea7b02cec122" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_9486296a-bf66-4773-a35c-beac9cc0c701" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_280e9fe3-c980-434a-922b-d8dd785303f4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_a898f4b9-9e65-4c14-9ca6-ea7b02cec122" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_280e9fe3-c980-434a-922b-d8dd785303f4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_81796746-d1ba-4438-9599-f760091ec85f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_a898f4b9-9e65-4c14-9ca6-ea7b02cec122" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_81796746-d1ba-4438-9599-f760091ec85f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncashInvestingAndFinancingItemsAbstract_7e1e5d93-7550-441d-94a4-2bc2a059e0ba" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoncashInvestingAndFinancingItemsAbstract"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_a898f4b9-9e65-4c14-9ca6-ea7b02cec122" xlink:to="loc_us-gaap_NoncashInvestingAndFinancingItemsAbstract_7e1e5d93-7550-441d-94a4-2bc2a059e0ba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability_69fd241e-6276-428b-acf8-30fddebd6c35" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoncashInvestingAndFinancingItemsAbstract_7e1e5d93-7550-441d-94a4-2bc2a059e0ba" xlink:to="loc_us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability_69fd241e-6276-428b-acf8-30fddebd6c35" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPaidNet_9054114e-fbed-4c46-9000-427ff29f496c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestPaidNet"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoncashInvestingAndFinancingItemsAbstract_7e1e5d93-7550-441d-94a4-2bc2a059e0ba" xlink:to="loc_us-gaap_InterestPaidNet_9054114e-fbed-4c46-9000-427ff29f496c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CapitalExpendituresIncurredButNotYetPaid_0e57b6d1-1bf5-478b-9fc5-1138a3fb1d8d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CapitalExpendituresIncurredButNotYetPaid"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoncashInvestingAndFinancingItemsAbstract_7e1e5d93-7550-441d-94a4-2bc2a059e0ba" xlink:to="loc_us-gaap_CapitalExpendituresIncurredButNotYetPaid_0e57b6d1-1bf5-478b-9fc5-1138a3fb1d8d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_OperatingLeaseRightOfUseAssetLeaseTerminationExpense_06b77047-bfd5-4233-943d-63ee3a76b484" xlink:href="tars-20220930.xsd#tars_OperatingLeaseRightOfUseAssetLeaseTerminationExpense"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoncashInvestingAndFinancingItemsAbstract_7e1e5d93-7550-441d-94a4-2bc2a059e0ba" xlink:to="loc_tars_OperatingLeaseRightOfUseAssetLeaseTerminationExpense_06b77047-bfd5-4233-943d-63ee3a76b484" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueIssuedForServices_47ad7202-dd7e-4636-aeb4-f1219ff77fd1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueIssuedForServices"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoncashInvestingAndFinancingItemsAbstract_7e1e5d93-7550-441d-94a4-2bc2a059e0ba" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueIssuedForServices_47ad7202-dd7e-4636-aeb4-f1219ff77fd1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/netLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/CondensedStatementsofStockholdersEquityParenthetical" xlink:type="simple" xlink:href="tars-20220930.xsd#CondensedStatementsofStockholdersEquityParenthetical"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/CondensedStatementsofStockholdersEquityParenthetical" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_9450afef-b4c2-46d3-8d19-e146feaaa3fd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfStockholdersEquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_37b9b8a8-6793-4cd1-8119-dd9dd030dab3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsOfStockIssuanceCosts"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_9450afef-b4c2-46d3-8d19-e146feaaa3fd" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_37b9b8a8-6793-4cd1-8119-dd9dd030dab3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/DescriptionofBusinessandPresentationofFinancialStatements" xlink:type="simple" xlink:href="tars-20220930.xsd#DescriptionofBusinessandPresentationofFinancialStatements"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/DescriptionofBusinessandPresentationofFinancialStatements" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_9b13ca1f-9592-41e3-a59c-8b70a0a61239" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessDescriptionAndBasisOfPresentationTextBlock_3ce884b8-97c7-42bd-a125-b71f25d5ed15" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessDescriptionAndBasisOfPresentationTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_9b13ca1f-9592-41e3-a59c-8b70a0a61239" xlink:to="loc_us-gaap_BusinessDescriptionAndBasisOfPresentationTextBlock_3ce884b8-97c7-42bd-a125-b71f25d5ed15" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/SummaryofSignificantAccountingPoliciesandUseofEstimates" xlink:type="simple" xlink:href="tars-20220930.xsd#SummaryofSignificantAccountingPoliciesandUseofEstimates"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/SummaryofSignificantAccountingPoliciesandUseofEstimates" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_c7fcc266-f0ee-411b-abba-97f864abe6d9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SignificantAccountingPoliciesTextBlock_a8e24bdd-9402-41f4-9019-ea982318a0c9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SignificantAccountingPoliciesTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_c7fcc266-f0ee-411b-abba-97f864abe6d9" xlink:to="loc_us-gaap_SignificantAccountingPoliciesTextBlock_a8e24bdd-9402-41f4-9019-ea982318a0c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/BalanceSheetAccountDetail" xlink:type="simple" xlink:href="tars-20220930.xsd#BalanceSheetAccountDetail"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/BalanceSheetAccountDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_c152f715-f288-4b02-aaff-9f945649650d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_444b9b25-d2ac-43bb-b09d-aa6a8bd52959" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SupplementalBalanceSheetDisclosuresTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_c152f715-f288-4b02-aaff-9f945649650d" xlink:to="loc_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_444b9b25-d2ac-43bb-b09d-aa6a8bd52959" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/StockholdersEquityandEquityIncentivePlans" xlink:type="simple" xlink:href="tars-20220930.xsd#StockholdersEquityandEquityIncentivePlans"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/StockholdersEquityandEquityIncentivePlans" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_613743ba-8bc7-41fb-a3d6-c451ee8d1d22" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_3d2fcf1a-e55f-4ea3-a9c0-5d3c8ee48488" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityNoteDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_613743ba-8bc7-41fb-a3d6-c451ee8d1d22" xlink:to="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_3d2fcf1a-e55f-4ea3-a9c0-5d3c8ee48488" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/StockBasedCompensation" xlink:type="simple" xlink:href="tars-20220930.xsd#StockBasedCompensation"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/StockBasedCompensation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_577adf19-7886-40b9-9484-0849112b743b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_854fd908-66b6-499f-92f4-af6c61124819" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_577adf19-7886-40b9-9484-0849112b743b" xlink:to="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_854fd908-66b6-499f-92f4-af6c61124819" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/NetLossIncomePerShare" xlink:type="simple" xlink:href="tars-20220930.xsd#NetLossIncomePerShare"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/NetLossIncomePerShare" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_0fe26f8b-fee9-4f98-92e0-16b06966cb5f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareTextBlock_8a4dc877-efae-46f7-88d9-a3219a91d21b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_0fe26f8b-fee9-4f98-92e0-16b06966cb5f" xlink:to="loc_us-gaap_EarningsPerShareTextBlock_8a4dc877-efae-46f7-88d9-a3219a91d21b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/FairValueMeasurements" xlink:type="simple" xlink:href="tars-20220930.xsd#FairValueMeasurements"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/FairValueMeasurements" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_30e486a8-1285-4082-8510-5feda7c4483a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresTextBlock_fb93b3aa-6d48-4984-bcbc-a17cf8bf327e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_30e486a8-1285-4082-8510-5feda7c4483a" xlink:to="loc_us-gaap_FairValueDisclosuresTextBlock_fb93b3aa-6d48-4984-bcbc-a17cf8bf327e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/CommitmentContingencies" xlink:type="simple" xlink:href="tars-20220930.xsd#CommitmentContingencies"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/CommitmentContingencies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_89800a05-ba45-4195-96ac-ace553e1cbf6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_2bbf506d-3f92-4683-97c0-524e79d8005f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingenciesDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_89800a05-ba45-4195-96ac-ace553e1cbf6" xlink:to="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_2bbf506d-3f92-4683-97c0-524e79d8005f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/OutLicenseAgreement" xlink:type="simple" xlink:href="tars-20220930.xsd#OutLicenseAgreement"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/OutLicenseAgreement" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_309020bc-0c11-46f3-8b33-9582565a80e8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementDisclosureTextBlock_190e1306-f577-4769-b2e2-8f3cd33b7ae4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollaborativeArrangementDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_309020bc-0c11-46f3-8b33-9582565a80e8" xlink:to="loc_us-gaap_CollaborativeArrangementDisclosureTextBlock_190e1306-f577-4769-b2e2-8f3cd33b7ae4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/CreditFacilityAgreement" xlink:type="simple" xlink:href="tars-20220930.xsd#CreditFacilityAgreement"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/CreditFacilityAgreement" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_b7be14c6-7c97-4387-89fb-d435166998dc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureTextBlock_fa069678-8c86-4dcf-9473-a3444684bf69" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_b7be14c6-7c97-4387-89fb-d435166998dc" xlink:to="loc_us-gaap_DebtDisclosureTextBlock_fa069678-8c86-4dcf-9473-a3444684bf69" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/SubsequentEvent" xlink:type="simple" xlink:href="tars-20220930.xsd#SubsequentEvent"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/SubsequentEvent" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventsAbstract_5b747a30-ac6b-42bf-a27e-33e159d5fed2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventsTextBlock_1a1975ab-bc39-44ae-aed9-254b437edbb1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventsAbstract_5b747a30-ac6b-42bf-a27e-33e159d5fed2" xlink:to="loc_us-gaap_SubsequentEventsTextBlock_1a1975ab-bc39-44ae-aed9-254b437edbb1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/SummaryofSignificantAccountingPoliciesandUseofEstimatesPolicies" xlink:type="simple" xlink:href="tars-20220930.xsd#SummaryofSignificantAccountingPoliciesandUseofEstimatesPolicies"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/SummaryofSignificantAccountingPoliciesandUseofEstimatesPolicies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_42b46ed6-b01b-4819-a6ed-2128163444c9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingPolicyPolicyTextBlock_22ca4e8c-c5ad-4e0b-adc3-281fc6071783" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentReportingPolicyPolicyTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_42b46ed6-b01b-4819-a6ed-2128163444c9" xlink:to="loc_us-gaap_SegmentReportingPolicyPolicyTextBlock_22ca4e8c-c5ad-4e0b-adc3-281fc6071783" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_b7d0b118-ba14-486a-8d7e-01a44f716bfd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BasisOfAccountingPolicyPolicyTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_42b46ed6-b01b-4819-a6ed-2128163444c9" xlink:to="loc_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_b7d0b118-ba14-486a-8d7e-01a44f716bfd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsUnrestrictedCashAndCashEquivalentsPolicy_758afc8c-6404-4d55-a52c-2391ce22a768" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsUnrestrictedCashAndCashEquivalentsPolicy"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_42b46ed6-b01b-4819-a6ed-2128163444c9" xlink:to="loc_us-gaap_CashAndCashEquivalentsUnrestrictedCashAndCashEquivalentsPolicy_758afc8c-6404-4d55-a52c-2391ce22a768" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesPolicy_8a5781c7-7b06-4abd-9152-526f8ba541ce" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MarketableSecuritiesPolicy"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_42b46ed6-b01b-4819-a6ed-2128163444c9" xlink:to="loc_us-gaap_MarketableSecuritiesPolicy_8a5781c7-7b06-4abd-9152-526f8ba541ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskCreditRisk_9f88e087-43bd-4cf6-b5ee-02b923e2fe0d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskCreditRisk"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_42b46ed6-b01b-4819-a6ed-2128163444c9" xlink:to="loc_us-gaap_ConcentrationRiskCreditRisk_9f88e087-43bd-4cf6-b5ee-02b923e2fe0d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRecognitionPolicyTextBlock_b68d0407-39a2-4efb-a475-0ff0f2e04ac6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRecognitionPolicyTextBlock"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_42b46ed6-b01b-4819-a6ed-2128163444c9" xlink:to="loc_us-gaap_RevenueRecognitionPolicyTextBlock_b68d0407-39a2-4efb-a475-0ff0f2e04ac6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_244c3d4c-9b93-40da-8202-4c3d75a49697" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpensePolicy"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_42b46ed6-b01b-4819-a6ed-2128163444c9" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_244c3d4c-9b93-40da-8202-4c3d75a49697" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_1273123f-c714-4415-b6b5-194ad6bb0725" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_42b46ed6-b01b-4819-a6ed-2128163444c9" xlink:to="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_1273123f-c714-4415-b6b5-194ad6bb0725" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerSharePolicyTextBlock_5caae80b-d373-4214-8326-54ec4a2464f2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerSharePolicyTextBlock"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_42b46ed6-b01b-4819-a6ed-2128163444c9" xlink:to="loc_us-gaap_EarningsPerSharePolicyTextBlock_5caae80b-d373-4214-8326-54ec4a2464f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_0b52e8aa-cfd4-417a-8042-572219f9a427" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementPolicyPolicyTextBlock"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_42b46ed6-b01b-4819-a6ed-2128163444c9" xlink:to="loc_us-gaap_FairValueMeasurementPolicyPolicyTextBlock_0b52e8aa-cfd4-417a-8042-572219f9a427" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_a54de1ec-0768-4b56-9c38-7372c505b750" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComprehensiveIncomePolicyPolicyTextBlock"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_42b46ed6-b01b-4819-a6ed-2128163444c9" xlink:to="loc_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_a54de1ec-0768-4b56-9c38-7372c505b750" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_abfadf7f-16c0-4698-af0c-a43b74f6977b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_42b46ed6-b01b-4819-a6ed-2128163444c9" xlink:to="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_abfadf7f-16c0-4698-af0c-a43b74f6977b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/BalanceSheetAccountDetailTables" xlink:type="simple" xlink:href="tars-20220930.xsd#BalanceSheetAccountDetailTables"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/BalanceSheetAccountDetailTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_6d219872-ba29-49a7-805f-16f2340b613c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_ScheduleOfPrepaidExpensesTableTextBlock_0726bfea-e7a4-4147-a9d0-64160b665980" xlink:href="tars-20220930.xsd#tars_ScheduleOfPrepaidExpensesTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_6d219872-ba29-49a7-805f-16f2340b613c" xlink:to="loc_tars_ScheduleOfPrepaidExpensesTableTextBlock_0726bfea-e7a4-4147-a9d0-64160b665980" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_ScheduleOfOtherReceivablesTableTextBlock_b9f13d11-f42e-401e-92ed-5571b137f0d1" xlink:href="tars-20220930.xsd#tars_ScheduleOfOtherReceivablesTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_6d219872-ba29-49a7-805f-16f2340b613c" xlink:to="loc_tars_ScheduleOfOtherReceivablesTableTextBlock_b9f13d11-f42e-401e-92ed-5571b137f0d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_1a6fd517-deaa-4fc9-8c49-b63d6aa3b568" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_6d219872-ba29-49a7-805f-16f2340b613c" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_1a6fd517-deaa-4fc9-8c49-b63d6aa3b568" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfOtherAssetsTableTextBlock_44f95953-9a06-4769-b02b-e7072e1ac3e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfOtherAssetsTableTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_6d219872-ba29-49a7-805f-16f2340b613c" xlink:to="loc_us-gaap_ScheduleOfOtherAssetsTableTextBlock_44f95953-9a06-4769-b02b-e7072e1ac3e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock_086bbf05-a50a-4426-8fef-ee5db1f3f8bf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_6d219872-ba29-49a7-805f-16f2340b613c" xlink:to="loc_us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock_086bbf05-a50a-4426-8fef-ee5db1f3f8bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesTableTextBlock_f9e3f96a-af93-4f81-8617-57a9a8e62734" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherLiabilitiesTableTextBlock"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_6d219872-ba29-49a7-805f-16f2340b613c" xlink:to="loc_us-gaap_OtherLiabilitiesTableTextBlock_f9e3f96a-af93-4f81-8617-57a9a8e62734" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/StockholdersEquityandEquityIncentivePlansTables" xlink:type="simple" xlink:href="tars-20220930.xsd#StockholdersEquityandEquityIncentivePlansTables"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/StockholdersEquityandEquityIncentivePlansTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_7a2bb16e-6793-4c94-9348-0fcefa8e6810" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTextBlock_5ca00453-85ce-49f8-9567-03bc89fb5db8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfStockByClassTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_7a2bb16e-6793-4c94-9348-0fcefa8e6810" xlink:to="loc_us-gaap_ScheduleOfStockByClassTextBlock_5ca00453-85ce-49f8-9567-03bc89fb5db8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/StockBasedCompensationTables" xlink:type="simple" xlink:href="tars-20220930.xsd#StockBasedCompensationTables"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/StockBasedCompensationTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_b93b30d2-9dbb-460d-8934-4b504ced633e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock_6e8936b0-4575-4d84-a042-a598edefaf5e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_b93b30d2-9dbb-460d-8934-4b504ced633e" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock_6e8936b0-4575-4d84-a042-a598edefaf5e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/NetLossIncomePerShareTables" xlink:type="simple" xlink:href="tars-20220930.xsd#NetLossIncomePerShareTables"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/NetLossIncomePerShareTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_5e54c6de-5755-46ef-8afd-a54a95447868" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_b9b246fb-081c-4cd3-bc3c-38952e99d571" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_5e54c6de-5755-46ef-8afd-a54a95447868" xlink:to="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_b9b246fb-081c-4cd3-bc3c-38952e99d571" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_e4308140-834e-4278-ad70-124e4f9aa306" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_5e54c6de-5755-46ef-8afd-a54a95447868" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_e4308140-834e-4278-ad70-124e4f9aa306" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/FairValueMeasurementsTables" xlink:type="simple" xlink:href="tars-20220930.xsd#FairValueMeasurementsTables"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/FairValueMeasurementsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_eff89a5b-2100-4ce2-9448-f99bb10437eb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByBalanceSheetGroupingTextBlock_74ba3a8b-8a3f-4ec2-80e0-54b22726e8da" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByBalanceSheetGroupingTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_eff89a5b-2100-4ce2-9448-f99bb10437eb" xlink:to="loc_us-gaap_FairValueByBalanceSheetGroupingTextBlock_74ba3a8b-8a3f-4ec2-80e0-54b22726e8da" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTextBlock_2b8f32a9-56e2-417b-91d7-e19cd4f55a52" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_eff89a5b-2100-4ce2-9448-f99bb10437eb" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTextBlock_2b8f32a9-56e2-417b-91d7-e19cd4f55a52" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrealizedGainLossOnInvestmentsTableTextBlock_668067f4-82bf-46ae-8999-8ad5e113f489" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnrealizedGainLossOnInvestmentsTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_eff89a5b-2100-4ce2-9448-f99bb10437eb" xlink:to="loc_us-gaap_UnrealizedGainLossOnInvestmentsTableTextBlock_668067f4-82bf-46ae-8999-8ad5e113f489" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/CommitmentContingenciesTables" xlink:type="simple" xlink:href="tars-20220930.xsd#CommitmentContingenciesTables"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/CommitmentContingenciesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_ab5e496c-ac2d-41cb-8c53-8f16311a7fee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_ScheduleOfLeaseAssetAndLiabilityAccountsTableTextBlock_690c3ac5-a108-4cbf-a0a6-d321309d4543" xlink:href="tars-20220930.xsd#tars_ScheduleOfLeaseAssetAndLiabilityAccountsTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_ab5e496c-ac2d-41cb-8c53-8f16311a7fee" xlink:to="loc_tars_ScheduleOfLeaseAssetAndLiabilityAccountsTableTextBlock_690c3ac5-a108-4cbf-a0a6-d321309d4543" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCostTableTextBlock_e882e652-9099-409c-8250-e0bde63deb5a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseCostTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_ab5e496c-ac2d-41cb-8c53-8f16311a7fee" xlink:to="loc_us-gaap_LeaseCostTableTextBlock_e882e652-9099-409c-8250-e0bde63deb5a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityMaturityTableTextBlock_18b2370f-2682-4b26-a489-37e0906b66fb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityMaturityTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_ab5e496c-ac2d-41cb-8c53-8f16311a7fee" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityMaturityTableTextBlock_18b2370f-2682-4b26-a489-37e0906b66fb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/CreditFacilityAgreementTables" xlink:type="simple" xlink:href="tars-20220930.xsd#CreditFacilityAgreementTables"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/CreditFacilityAgreementTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_3b9a6e97-b54d-43a5-b70c-8f95588b72bc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeAndInterestExpenseDisclosureTableTextBlock_4b6ee15d-c2cf-4c3a-bfae-15f40a1d5b91" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestIncomeAndInterestExpenseDisclosureTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_3b9a6e97-b54d-43a5-b70c-8f95588b72bc" xlink:to="loc_us-gaap_InterestIncomeAndInterestExpenseDisclosureTableTextBlock_4b6ee15d-c2cf-4c3a-bfae-15f40a1d5b91" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDebtTableTextBlock_8478388c-1782-41b7-9377-bc011ab86b64" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfDebtTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_3b9a6e97-b54d-43a5-b70c-8f95588b72bc" xlink:to="loc_us-gaap_ScheduleOfDebtTableTextBlock_8478388c-1782-41b7-9377-bc011ab86b64" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/DescriptionofBusinessandPresentationofFinancialStatementsDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#DescriptionofBusinessandPresentationofFinancialStatementsDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/DescriptionofBusinessandPresentationofFinancialStatementsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_fbbca1d3-f38a-4856-99d7-8d5538fe18e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfReportableSegments_cc944fe2-bf45-4b57-b8a8-1c15dd6ab1c9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NumberOfReportableSegments"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_fbbca1d3-f38a-4856-99d7-8d5538fe18e0" xlink:to="loc_us-gaap_NumberOfReportableSegments_cc944fe2-bf45-4b57-b8a8-1c15dd6ab1c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfOperatingSegments_ba3ea0cb-f9e6-4430-96b8-ade298c03730" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NumberOfOperatingSegments"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_fbbca1d3-f38a-4856-99d7-8d5538fe18e0" xlink:to="loc_us-gaap_NumberOfOperatingSegments_ba3ea0cb-f9e6-4430-96b8-ade298c03730" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/SummaryofSignificantAccountingPoliciesandUseofEstimatesDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#SummaryofSignificantAccountingPoliciesandUseofEstimatesDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/SummaryofSignificantAccountingPoliciesandUseofEstimatesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_1a17a419-4db7-4535-8cd9-79afd5f4d337" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_4452713d-5278-4c6d-abe9-529cf576c4f4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_1a17a419-4db7-4535-8cd9-79afd5f4d337" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_4452713d-5278-4c6d-abe9-529cf576c4f4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/BalanceSheetAccountDetailPrepaidExpensesDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#BalanceSheetAccountDetailPrepaidExpensesDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/BalanceSheetAccountDetailPrepaidExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_ae1f5230-e7c7-404d-a478-fe928d0d6957" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherPrepaidExpenseCurrent_c5212eb7-c7c7-4200-a75a-ffb46eb21b48" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherPrepaidExpenseCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_ae1f5230-e7c7-404d-a478-fe928d0d6957" xlink:to="loc_us-gaap_OtherPrepaidExpenseCurrent_c5212eb7-c7c7-4200-a75a-ffb46eb21b48" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidInsurance_a3970fb0-7fef-4848-9159-68e8d7f1f56d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrepaidInsurance"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_ae1f5230-e7c7-404d-a478-fe928d0d6957" xlink:to="loc_us-gaap_PrepaidInsurance_a3970fb0-7fef-4848-9159-68e8d7f1f56d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseCurrent_d283b1f9-fe1c-42af-a933-042bf7270134" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrepaidExpenseCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_ae1f5230-e7c7-404d-a478-fe928d0d6957" xlink:to="loc_us-gaap_PrepaidExpenseCurrent_d283b1f9-fe1c-42af-a933-042bf7270134" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/BalanceSheetAccountDetailOtherReceivablesDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#BalanceSheetAccountDetailOtherReceivablesDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/BalanceSheetAccountDetailOtherReceivablesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_d0b351ba-473b-4a16-94b3-262fd7f6c3c4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_FeeReimbursementReceivableCurrent_a7189e9d-4c96-4270-b224-e3b883285a4e" xlink:href="tars-20220930.xsd#tars_FeeReimbursementReceivableCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_d0b351ba-473b-4a16-94b3-262fd7f6c3c4" xlink:to="loc_tars_FeeReimbursementReceivableCurrent_a7189e9d-4c96-4270-b224-e3b883285a4e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_PayrollTaxReceivableCurrent_deed8333-6f4c-40a3-bfdd-19a19ff03135" xlink:href="tars-20220930.xsd#tars_PayrollTaxReceivableCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_d0b351ba-473b-4a16-94b3-262fd7f6c3c4" xlink:to="loc_tars_PayrollTaxReceivableCurrent_deed8333-6f4c-40a3-bfdd-19a19ff03135" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_ClinicalReceivablesCurrent_4cb7972e-c13c-4333-869b-c7bf99387a8c" xlink:href="tars-20220930.xsd#tars_ClinicalReceivablesCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_d0b351ba-473b-4a16-94b3-262fd7f6c3c4" xlink:to="loc_tars_ClinicalReceivablesCurrent_4cb7972e-c13c-4333-869b-c7bf99387a8c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestReceivableCurrent_c7e32ab8-0256-47c2-afb8-2c0a639ebac3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestReceivableCurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_d0b351ba-473b-4a16-94b3-262fd7f6c3c4" xlink:to="loc_us-gaap_InterestReceivableCurrent_c7e32ab8-0256-47c2-afb8-2c0a639ebac3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxesReceivable_fa50e3aa-b7c7-45eb-a9bb-cea7ce618041" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxesReceivable"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_d0b351ba-473b-4a16-94b3-262fd7f6c3c4" xlink:to="loc_us-gaap_IncomeTaxesReceivable_fa50e3aa-b7c7-45eb-a9bb-cea7ce618041" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherReceivablesNetCurrent_3ea9c2e5-d8f3-4ffa-88ef-a024c60235cf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherReceivablesNetCurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_d0b351ba-473b-4a16-94b3-262fd7f6c3c4" xlink:to="loc_us-gaap_OtherReceivablesNetCurrent_3ea9c2e5-d8f3-4ffa-88ef-a024c60235cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/BalanceSheetAccountDetailPropertyandEquipmentNetofAccumulatedDepreciationDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#BalanceSheetAccountDetailPropertyandEquipmentNetofAccumulatedDepreciationDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/BalanceSheetAccountDetailPropertyandEquipmentNetofAccumulatedDepreciationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_21a0ffa0-c71f-4592-91cb-fd0236f103a8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_a27ac185-2cb6-4bcb-9a2b-618a802b467b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_21a0ffa0-c71f-4592-91cb-fd0236f103a8" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_a27ac185-2cb6-4bcb-9a2b-618a802b467b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_7ea8a7a6-2d24-49d9-aa8b-479651c38838" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_a27ac185-2cb6-4bcb-9a2b-618a802b467b" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_7ea8a7a6-2d24-49d9-aa8b-479651c38838" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_95f38e5e-058e-4f57-be7b-f4d2d9847c22" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_7ea8a7a6-2d24-49d9-aa8b-479651c38838" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_95f38e5e-058e-4f57-be7b-f4d2d9847c22" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_2cffd0e9-b20f-4bde-bfdc-612ee1c60f4d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FurnitureAndFixturesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_95f38e5e-058e-4f57-be7b-f4d2d9847c22" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_2cffd0e9-b20f-4bde-bfdc-612ee1c60f4d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OfficeEquipmentMember_04fb5b57-6927-468f-b78b-200b510e0484" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OfficeEquipmentMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_95f38e5e-058e-4f57-be7b-f4d2d9847c22" xlink:to="loc_us-gaap_OfficeEquipmentMember_04fb5b57-6927-468f-b78b-200b510e0484" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherMachineryAndEquipmentMember_780a36ea-9a37-4758-8b32-6069ade8832e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherMachineryAndEquipmentMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_95f38e5e-058e-4f57-be7b-f4d2d9847c22" xlink:to="loc_us-gaap_OtherMachineryAndEquipmentMember_780a36ea-9a37-4758-8b32-6069ade8832e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_d98edf36-5738-4290-ab63-9f9e0f876132" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseholdImprovementsMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_95f38e5e-058e-4f57-be7b-f4d2d9847c22" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_d98edf36-5738-4290-ab63-9f9e0f876132" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_27fef9bc-4002-42c3-90a7-41a9e1ce75ce" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_a27ac185-2cb6-4bcb-9a2b-618a802b467b" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentLineItems_27fef9bc-4002-42c3-90a7-41a9e1ce75ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_cbb4c587-295e-4ee2-8614-d00ff62489d7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_27fef9bc-4002-42c3-90a7-41a9e1ce75ce" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_cbb4c587-295e-4ee2-8614-d00ff62489d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_198fd3f0-1967-46de-a579-dd794e20136b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_27fef9bc-4002-42c3-90a7-41a9e1ce75ce" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_198fd3f0-1967-46de-a579-dd794e20136b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_3ef518c7-3c34-4628-954f-92ec9b367db1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_27fef9bc-4002-42c3-90a7-41a9e1ce75ce" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_3ef518c7-3c34-4628-954f-92ec9b367db1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_fdebacb4-1ec0-466c-b23c-671874eb2bdb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Depreciation"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_27fef9bc-4002-42c3-90a7-41a9e1ce75ce" xlink:to="loc_us-gaap_Depreciation_fdebacb4-1ec0-466c-b23c-671874eb2bdb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/BalanceSheetAccountDetailOtherAssetsDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#BalanceSheetAccountDetailOtherAssetsDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/BalanceSheetAccountDetailOtherAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_269a8c27-efa3-4d53-872c-077afe8b03e6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepositAssets_bff8ba28-09b6-4253-91a3-1d9acc4ae23c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepositAssets"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_269a8c27-efa3-4d53-872c-077afe8b03e6" xlink:to="loc_us-gaap_DepositAssets_bff8ba28-09b6-4253-91a3-1d9acc4ae23c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_EquityWarrantRights_74859dea-ec03-4b74-be5b-1d07bbbe0929" xlink:href="tars-20220930.xsd#tars_EquityWarrantRights"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_269a8c27-efa3-4d53-872c-077afe8b03e6" xlink:to="loc_tars_EquityWarrantRights_74859dea-ec03-4b74-be5b-1d07bbbe0929" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsMiscellaneousNoncurrent_36c756e3-566c-4a2c-acb7-1017f847ab25" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsMiscellaneousNoncurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_269a8c27-efa3-4d53-872c-077afe8b03e6" xlink:to="loc_us-gaap_OtherAssetsMiscellaneousNoncurrent_36c756e3-566c-4a2c-acb7-1017f847ab25" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_5ae51874-2916-4ffe-8021-c1b2e8578722" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_269a8c27-efa3-4d53-872c-077afe8b03e6" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_5ae51874-2916-4ffe-8021-c1b2e8578722" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/BalanceSheetAccountDetailAccountsPayableandAccruedLiabilitiesDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#BalanceSheetAccountDetailAccountsPayableandAccruedLiabilitiesDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/BalanceSheetAccountDetailAccountsPayableandAccruedLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_15d7b4dd-6183-42e3-bf38-f4eda714ed61" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableTradeCurrent_0b74b7aa-350e-4b32-8ff0-34d2f305b537" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableTradeCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_15d7b4dd-6183-42e3-bf38-f4eda714ed61" xlink:to="loc_us-gaap_AccountsPayableTradeCurrent_0b74b7aa-350e-4b32-8ff0-34d2f305b537" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_b607a67e-07d6-4f77-b652-81b72c7e7b66" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_15d7b4dd-6183-42e3-bf38-f4eda714ed61" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_b607a67e-07d6-4f77-b652-81b72c7e7b66" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_AccruedClinicalStudiesCurrent_f7ea6a86-e2ff-465d-b29f-ba2c27050f36" xlink:href="tars-20220930.xsd#tars_AccruedClinicalStudiesCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_15d7b4dd-6183-42e3-bf38-f4eda714ed61" xlink:to="loc_tars_AccruedClinicalStudiesCurrent_f7ea6a86-e2ff-465d-b29f-ba2c27050f36" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_9e10f5e2-741e-43c7-a6d9-9e3cbcfbfa6c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_15d7b4dd-6183-42e3-bf38-f4eda714ed61" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_9e10f5e2-741e-43c7-a6d9-9e3cbcfbfa6c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPayableCurrent_168d4bfc-55d6-4fa3-a22b-eeb4a226a4b5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestPayableCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_15d7b4dd-6183-42e3-bf38-f4eda714ed61" xlink:to="loc_us-gaap_InterestPayableCurrent_168d4bfc-55d6-4fa3-a22b-eeb4a226a4b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_f86d2734-d5ce-4fac-be81-1d4dc6431dec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedIncomeTaxesCurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_15d7b4dd-6183-42e3-bf38-f4eda714ed61" xlink:to="loc_us-gaap_AccruedIncomeTaxesCurrent_f86d2734-d5ce-4fac-be81-1d4dc6431dec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredCompensationShareBasedArrangementsLiabilityCurrent_eed841b0-c47b-46d3-aed0-df74ca3127c4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredCompensationShareBasedArrangementsLiabilityCurrent"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_15d7b4dd-6183-42e3-bf38-f4eda714ed61" xlink:to="loc_us-gaap_DeferredCompensationShareBasedArrangementsLiabilityCurrent_eed841b0-c47b-46d3-aed0-df74ca3127c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent_2a330070-7f24-47c7-9f71-9ba68864b0c1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_15d7b4dd-6183-42e3-bf38-f4eda714ed61" xlink:to="loc_us-gaap_AccountsPayableAndOtherAccruedLiabilitiesCurrent_2a330070-7f24-47c7-9f71-9ba68864b0c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/BalanceSheetAccountDetailOtherLongTermLiabilitiesDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#BalanceSheetAccountDetailOtherLongTermLiabilitiesDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/BalanceSheetAccountDetailOtherLongTermLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_0ebe1850-529a-4015-a439-70c2edcd2f69" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_369b24e7-b371-4833-86d5-2991d9240210" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_0ebe1850-529a-4015-a439-70c2edcd2f69" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_369b24e7-b371-4833-86d5-2991d9240210" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilitiesNoncurrent_629aca3e-5df5-4f3f-a677-7334367c0afa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLiabilitiesNoncurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_0ebe1850-529a-4015-a439-70c2edcd2f69" xlink:to="loc_us-gaap_DerivativeLiabilitiesNoncurrent_629aca3e-5df5-4f3f-a677-7334367c0afa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_4c8e09c2-5f71-480d-a89a-380bfef42fe3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_0ebe1850-529a-4015-a439-70c2edcd2f69" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_4c8e09c2-5f71-480d-a89a-380bfef42fe3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/StockholdersEquityandEquityIncentivePlansAdditionalInformationDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#StockholdersEquityandEquityIncentivePlansAdditionalInformationDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/StockholdersEquityandEquityIncentivePlansAdditionalInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_0f9b743c-3a9b-4e18-8652-f38dc3fa3859" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_0d3710f0-a89c-4472-86d1-125680039fdd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_0f9b743c-3a9b-4e18-8652-f38dc3fa3859" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_0d3710f0-a89c-4472-86d1-125680039fdd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_d3954c41-63c4-462e-90f6-618defd65e70" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_0d3710f0-a89c-4472-86d1-125680039fdd" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_d3954c41-63c4-462e-90f6-618defd65e70" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_4a4a155a-5b69-475e-b92f-6d34038e423e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_d3954c41-63c4-462e-90f6-618defd65e70" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_4a4a155a-5b69-475e-b92f-6d34038e423e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_FollowOnPublicOfferingMember_97adb031-ee53-4338-8ba1-b5e136a74e98" xlink:href="tars-20220930.xsd#tars_FollowOnPublicOfferingMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_4a4a155a-5b69-475e-b92f-6d34038e423e" xlink:to="loc_tars_FollowOnPublicOfferingMember_97adb031-ee53-4338-8ba1-b5e136a74e98" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OverAllotmentOptionMember_b2ad7ffc-1be5-4ecd-8780-a592a8d217ab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OverAllotmentOptionMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_4a4a155a-5b69-475e-b92f-6d34038e423e" xlink:to="loc_us-gaap_OverAllotmentOptionMember_b2ad7ffc-1be5-4ecd-8780-a592a8d217ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_bbed3f7e-0aab-48f6-a15a-4376cad0b590" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_0d3710f0-a89c-4472-86d1-125680039fdd" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_bbed3f7e-0aab-48f6-a15a-4376cad0b590" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_9ecebe81-0b6e-44bd-95c2-cf43e7b94ca2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_bbed3f7e-0aab-48f6-a15a-4376cad0b590" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_9ecebe81-0b6e-44bd-95c2-cf43e7b94ca2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_ba6fb022-dce0-4b5a-bf85-bbfe3e6c9110" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_bbed3f7e-0aab-48f6-a15a-4376cad0b590" xlink:to="loc_us-gaap_CommonStockSharesIssued_ba6fb022-dce0-4b5a-bf85-bbfe3e6c9110" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_CommonStockNumberOfVotes_39426ecc-57f4-4a08-8ec5-b341c885c065" xlink:href="tars-20220930.xsd#tars_CommonStockNumberOfVotes"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_bbed3f7e-0aab-48f6-a15a-4376cad0b590" xlink:to="loc_tars_CommonStockNumberOfVotes_39426ecc-57f4-4a08-8ec5-b341c885c065" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_4db4e652-4b89-4bc0-a438-477b368b899e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_bbed3f7e-0aab-48f6-a15a-4376cad0b590" xlink:to="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_4db4e652-4b89-4bc0-a438-477b368b899e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_912db3db-ca48-4f32-8eaa-9924493ae5c9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_bbed3f7e-0aab-48f6-a15a-4376cad0b590" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_912db3db-ca48-4f32-8eaa-9924493ae5c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_4b44f304-7445-4385-9328-b2d31be89cf3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockPricePerShare"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_bbed3f7e-0aab-48f6-a15a-4376cad0b590" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_4b44f304-7445-4385-9328-b2d31be89cf3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_SaleOfStockConsiderationReceivedOnTransactionGross_0ae9e70f-89ca-40e7-b33f-9e49c1282c98" xlink:href="tars-20220930.xsd#tars_SaleOfStockConsiderationReceivedOnTransactionGross"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_bbed3f7e-0aab-48f6-a15a-4376cad0b590" xlink:to="loc_tars_SaleOfStockConsiderationReceivedOnTransactionGross_0ae9e70f-89ca-40e7-b33f-9e49c1282c98" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_4295f3df-1245-43d8-8678-71dad11d0d64" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_bbed3f7e-0aab-48f6-a15a-4376cad0b590" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_4295f3df-1245-43d8-8678-71dad11d0d64" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_CommonStockCapitalSharesReservedForFutureIssuanceEmployeeStockPurchasePlan_442cb2b4-fcf4-4d5b-b5d1-9e586f3085cc" xlink:href="tars-20220930.xsd#tars_CommonStockCapitalSharesReservedForFutureIssuanceEmployeeStockPurchasePlan"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_bbed3f7e-0aab-48f6-a15a-4376cad0b590" xlink:to="loc_tars_CommonStockCapitalSharesReservedForFutureIssuanceEmployeeStockPurchasePlan_442cb2b4-fcf4-4d5b-b5d1-9e586f3085cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/StockholdersEquityandEquityIncentivePlansSharesReservedforIssuanceDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#StockholdersEquityandEquityIncentivePlansSharesReservedforIssuanceDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/StockholdersEquityandEquityIncentivePlansSharesReservedforIssuanceDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_23fa17e5-2c3d-4724-b40c-842721866aad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_CommonStockCapitalSharesReservedForFutureIssuanceEffectOfStockAwardsAvailableForFutureGrant_169e0cd4-5401-4ae0-9b60-c6b26f2aaa12" xlink:href="tars-20220930.xsd#tars_CommonStockCapitalSharesReservedForFutureIssuanceEffectOfStockAwardsAvailableForFutureGrant"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_23fa17e5-2c3d-4724-b40c-842721866aad" xlink:to="loc_tars_CommonStockCapitalSharesReservedForFutureIssuanceEffectOfStockAwardsAvailableForFutureGrant_169e0cd4-5401-4ae0-9b60-c6b26f2aaa12" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_CommonStockCapitalSharesReservedForFutureIssuanceEmployeeStockPurchasePlan_2580c983-b38d-4eac-b7de-cc440dd0db33" xlink:href="tars-20220930.xsd#tars_CommonStockCapitalSharesReservedForFutureIssuanceEmployeeStockPurchasePlan"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_23fa17e5-2c3d-4724-b40c-842721866aad" xlink:to="loc_tars_CommonStockCapitalSharesReservedForFutureIssuanceEmployeeStockPurchasePlan_2580c983-b38d-4eac-b7de-cc440dd0db33" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_CommonStockCapitalSharesReservedForFutureIssuanceEffectOfStockOptionsIssuedAndOutstanding_eac3aa49-9bd9-4a54-a9d3-45fb1012c336" xlink:href="tars-20220930.xsd#tars_CommonStockCapitalSharesReservedForFutureIssuanceEffectOfStockOptionsIssuedAndOutstanding"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_23fa17e5-2c3d-4724-b40c-842721866aad" xlink:to="loc_tars_CommonStockCapitalSharesReservedForFutureIssuanceEffectOfStockOptionsIssuedAndOutstanding_eac3aa49-9bd9-4a54-a9d3-45fb1012c336" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_CommonStockCapitalSharesReservedForFutureIssuanceEffectOfRestrictedStockUnitsAvailableForFutureGrant_10e1a2ec-07c2-4d01-afba-130b251eeaf3" xlink:href="tars-20220930.xsd#tars_CommonStockCapitalSharesReservedForFutureIssuanceEffectOfRestrictedStockUnitsAvailableForFutureGrant"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_23fa17e5-2c3d-4724-b40c-842721866aad" xlink:to="loc_tars_CommonStockCapitalSharesReservedForFutureIssuanceEffectOfRestrictedStockUnitsAvailableForFutureGrant_10e1a2ec-07c2-4d01-afba-130b251eeaf3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_73957379-c171-4e26-b961-17def99ca6dd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_23fa17e5-2c3d-4724-b40c-842721866aad" xlink:to="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_73957379-c171-4e26-b961-17def99ca6dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/StockBasedCompensationExpenseDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#StockBasedCompensationExpenseDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/StockBasedCompensationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_df060dcf-a32e-4b2b-9cb4-20a2014fe1e2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_030de2c2-5dd2-4c9e-b207-f7550ec61880" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_df060dcf-a32e-4b2b-9cb4-20a2014fe1e2" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_030de2c2-5dd2-4c9e-b207-f7550ec61880" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_ec1da8d8-52c5-4591-83b0-e4ef24ff86c0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_030de2c2-5dd2-4c9e-b207-f7550ec61880" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_ec1da8d8-52c5-4591-83b0-e4ef24ff86c0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_6d655c85-a5bb-4c88-a88d-7d33f2f38844" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_ec1da8d8-52c5-4591-83b0-e4ef24ff86c0" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_6d655c85-a5bb-4c88-a88d-7d33f2f38844" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_98e313e6-1619-4f74-819b-f95e6bb16178" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_6d655c85-a5bb-4c88-a88d-7d33f2f38844" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_98e313e6-1619-4f74-819b-f95e6bb16178" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpenseMember_85836dd7-45fb-4fc2-beeb-911e9ecf55f7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GeneralAndAdministrativeExpenseMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_6d655c85-a5bb-4c88-a88d-7d33f2f38844" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpenseMember_85836dd7-45fb-4fc2-beeb-911e9ecf55f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_a7977f12-1090-4001-afb4-08dfb3a8c7ed" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_030de2c2-5dd2-4c9e-b207-f7550ec61880" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_a7977f12-1090-4001-afb4-08dfb3a8c7ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_24333b58-0f91-453d-9397-9fbe3e32ebee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_a7977f12-1090-4001-afb4-08dfb3a8c7ed" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_24333b58-0f91-453d-9397-9fbe3e32ebee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/NetLossIncomePerShareDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#NetLossIncomePerShareDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/NetLossIncomePerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_7f342684-6a01-471c-ba83-fa7713b5069e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasicAbstract_4aef1bd3-f978-4b28-884a-935562a96fd1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasicAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_7f342684-6a01-471c-ba83-fa7713b5069e" xlink:to="loc_us-gaap_EarningsPerShareBasicAbstract_4aef1bd3-f978-4b28-884a-935562a96fd1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_dd04230a-4c0e-438c-89a9-746af0385919" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareBasicAbstract_4aef1bd3-f978-4b28-884a-935562a96fd1" xlink:to="loc_us-gaap_NetIncomeLoss_dd04230a-4c0e-438c-89a9-746af0385919" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/netLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesBasic_3ee1d9c3-114b-4990-97fb-9608170fa236" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesBasic"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareBasicAbstract_4aef1bd3-f978-4b28-884a-935562a96fd1" xlink:to="loc_us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesBasic_3ee1d9c3-114b-4990-97fb-9608170fa236" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_40f11925-d8ea-405d-84e5-69567ca217db" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareBasicAbstract_4aef1bd3-f978-4b28-884a-935562a96fd1" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_40f11925-d8ea-405d-84e5-69567ca217db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_0c463d09-5574-4593-aa9d-c7b1603f2715" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareBasicAbstract_4aef1bd3-f978-4b28-884a-935562a96fd1" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_0c463d09-5574-4593-aa9d-c7b1603f2715" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_27ac6453-2cb1-4943-bbf3-7fb43efdc0ee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareBasicAbstract_4aef1bd3-f978-4b28-884a-935562a96fd1" xlink:to="loc_us-gaap_EarningsPerShareBasic_27ac6453-2cb1-4943-bbf3-7fb43efdc0ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDilutedAbstract_e7085a00-79ba-4a12-a345-94d5f09fe7de" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareDilutedAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_7f342684-6a01-471c-ba83-fa7713b5069e" xlink:to="loc_us-gaap_EarningsPerShareDilutedAbstract_e7085a00-79ba-4a12-a345-94d5f09fe7de" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_cace6757-a9b8-4844-a403-3a48ee818c2c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedAbstract_e7085a00-79ba-4a12-a345-94d5f09fe7de" xlink:to="loc_us-gaap_NetIncomeLoss_cace6757-a9b8-4844-a403-3a48ee818c2c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesDiluted_139d4ff1-57e6-4286-90a8-bef5339b7c3b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesDiluted"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedAbstract_e7085a00-79ba-4a12-a345-94d5f09fe7de" xlink:to="loc_us-gaap_UndistributedEarningsLossAllocatedToParticipatingSecuritiesDiluted_139d4ff1-57e6-4286-90a8-bef5339b7c3b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_4364fa71-eaf3-475a-b5df-3257a48a536f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedAbstract_e7085a00-79ba-4a12-a345-94d5f09fe7de" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_4364fa71-eaf3-475a-b5df-3257a48a536f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_b522d8c8-6e83-4246-9af2-9c59cc11e599" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedAbstract_e7085a00-79ba-4a12-a345-94d5f09fe7de" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_b522d8c8-6e83-4246-9af2-9c59cc11e599" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/netLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustmentAbstract_e92e5670-8008-48ff-b540-8c19b933c834" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustmentAbstract"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedAbstract_e7085a00-79ba-4a12-a345-94d5f09fe7de" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustmentAbstract_e92e5670-8008-48ff-b540-8c19b933c834" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_5559787d-1f95-472c-b586-7a828d63c83b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustmentAbstract_e92e5670-8008-48ff-b540-8c19b933c834" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_5559787d-1f95-472c-b586-7a828d63c83b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_d58edb5a-bdbf-4e1f-8a72-2f6902149232" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedAbstract_e7085a00-79ba-4a12-a345-94d5f09fe7de" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_d58edb5a-bdbf-4e1f-8a72-2f6902149232" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_18deb07c-27c9-4884-957a-a33a75ade3e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedAbstract_e7085a00-79ba-4a12-a345-94d5f09fe7de" xlink:to="loc_us-gaap_EarningsPerShareDiluted_18deb07c-27c9-4884-957a-a33a75ade3e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/NetLossIncomePerShareAntidilutiveSecuritiesDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#NetLossIncomePerShareAntidilutiveSecuritiesDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/NetLossIncomePerShareAntidilutiveSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_4dc06025-31a9-4297-bd3e-e94162327b46" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_3ed2d69f-3351-4c9b-984b-bab08c5d4fba" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_4dc06025-31a9-4297-bd3e-e94162327b46" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_3ed2d69f-3351-4c9b-984b-bab08c5d4fba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_4cfe4f1d-429d-4fcb-9184-2704ce05e957" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_3ed2d69f-3351-4c9b-984b-bab08c5d4fba" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_4cfe4f1d-429d-4fcb-9184-2704ce05e957" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_29ea0fdd-721d-4011-b34e-d4d5382062b5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_4cfe4f1d-429d-4fcb-9184-2704ce05e957" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_29ea0fdd-721d-4011-b34e-d4d5382062b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_ac1cbbe4-1959-45b2-a21d-c150127bbc31" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_29ea0fdd-721d-4011-b34e-d4d5382062b5" xlink:to="loc_us-gaap_EmployeeStockOptionMember_ac1cbbe4-1959-45b2-a21d-c150127bbc31" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_ShareBasedPaymentArrangementEarlyExercisedOptionMember_826500fc-4b76-4605-9be0-3f72f8fcdc04" xlink:href="tars-20220930.xsd#tars_ShareBasedPaymentArrangementEarlyExercisedOptionMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_29ea0fdd-721d-4011-b34e-d4d5382062b5" xlink:to="loc_tars_ShareBasedPaymentArrangementEarlyExercisedOptionMember_826500fc-4b76-4605-9be0-3f72f8fcdc04" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_ShareBasedPaymentArrangementEquityInstrumentsOtherThanOptionsRestrictedStockUnitsUnvestedMember_841c158e-ea4d-49a5-b8dc-97f59d807fdc" xlink:href="tars-20220930.xsd#tars_ShareBasedPaymentArrangementEquityInstrumentsOtherThanOptionsRestrictedStockUnitsUnvestedMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_29ea0fdd-721d-4011-b34e-d4d5382062b5" xlink:to="loc_tars_ShareBasedPaymentArrangementEquityInstrumentsOtherThanOptionsRestrictedStockUnitsUnvestedMember_841c158e-ea4d-49a5-b8dc-97f59d807fdc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_90ffb399-27ca-4908-8118-ca6a949a9cc3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_3ed2d69f-3351-4c9b-984b-bab08c5d4fba" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_90ffb399-27ca-4908-8118-ca6a949a9cc3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_9125e27b-30fb-4721-b822-1451da27fb11" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_90ffb399-27ca-4908-8118-ca6a949a9cc3" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_9125e27b-30fb-4721-b822-1451da27fb11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/FairValueMeasurementsFinancialInstrumentsMeasuredatFairValueDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#FairValueMeasurementsFinancialInstrumentsMeasuredatFairValueDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/FairValueMeasurementsFinancialInstrumentsMeasuredatFairValueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_c369d079-16a1-46dc-8ece-c5420f4ee36e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByBalanceSheetGroupingTable_38f9ab03-7bae-4537-86c1-2138588c8725" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByBalanceSheetGroupingTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_c369d079-16a1-46dc-8ece-c5420f4ee36e" xlink:to="loc_us-gaap_FairValueByBalanceSheetGroupingTable_38f9ab03-7bae-4537-86c1-2138588c8725" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_ff6241cb-01ac-406d-93f3-a4c017cf7104" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_38f9ab03-7bae-4537-86c1-2138588c8725" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_ff6241cb-01ac-406d-93f3-a4c017cf7104" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_87d909bc-cd0a-4cb5-bb26-9ae073223744" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_ff6241cb-01ac-406d-93f3-a4c017cf7104" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_87d909bc-cd0a-4cb5-bb26-9ae073223744" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_2f83a8da-8dde-4dd3-a4f1-19103842f875" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_87d909bc-cd0a-4cb5-bb26-9ae073223744" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_2f83a8da-8dde-4dd3-a4f1-19103842f875" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_2fc9c953-2900-447a-b99a-09938d33ab65" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_87d909bc-cd0a-4cb5-bb26-9ae073223744" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_2fc9c953-2900-447a-b99a-09938d33ab65" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_e359519d-8390-4d3d-b80e-e03d7ec74ce4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_87d909bc-cd0a-4cb5-bb26-9ae073223744" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_e359519d-8390-4d3d-b80e-e03d7ec74ce4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_d8439504-13e9-42ce-9521-41bf7825dd63" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_38f9ab03-7bae-4537-86c1-2138588c8725" xlink:to="loc_us-gaap_FinancialInstrumentAxis_d8439504-13e9-42ce-9521-41bf7825dd63" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_ef501976-39d7-43ee-94a7-706d884ec4db" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_d8439504-13e9-42ce-9521-41bf7825dd63" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_ef501976-39d7-43ee-94a7-706d884ec4db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_60882189-4d93-4e0a-9984-1506c649f1d0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_ef501976-39d7-43ee-94a7-706d884ec4db" xlink:to="loc_us-gaap_MoneyMarketFundsMember_60882189-4d93-4e0a-9984-1506c649f1d0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_239de8a4-9685-4621-abf3-23b51fc7d73f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_ef501976-39d7-43ee-94a7-706d884ec4db" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_239de8a4-9685-4621-abf3-23b51fc7d73f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_e2b1fd42-fd2b-46d1-97ba-d4f74a5f6c76" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommercialPaperMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_ef501976-39d7-43ee-94a7-706d884ec4db" xlink:to="loc_us-gaap_CommercialPaperMember_e2b1fd42-fd2b-46d1-97ba-d4f74a5f6c76" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentDebtSecuritiesMember_f5ea6f83-ece4-4eff-b56b-706abdda60ef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USGovernmentDebtSecuritiesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_ef501976-39d7-43ee-94a7-706d884ec4db" xlink:to="loc_us-gaap_USGovernmentDebtSecuritiesMember_f5ea6f83-ece4-4eff-b56b-706abdda60ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_b35c40b4-5a9d-4f56-8351-3552faa905ec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_38f9ab03-7bae-4537-86c1-2138588c8725" xlink:to="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_b35c40b4-5a9d-4f56-8351-3552faa905ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract_89ee899b-a79a-4809-b049-ca76634816ea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_b35c40b4-5a9d-4f56-8351-3552faa905ec" xlink:to="loc_us-gaap_AssetsAbstract_89ee899b-a79a-4809-b049-ca76634816ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_5f2d2de7-1cfe-44a9-ad54-ac2446c3d8c2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_89ee899b-a79a-4809-b049-ca76634816ea" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_5f2d2de7-1cfe-44a9-ad54-ac2446c3d8c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_DebtSecuritiesAvailableForSaleAndCashAndCashEquivalents_56beeca4-f86e-486a-9544-b82f80f13147" xlink:href="tars-20220930.xsd#tars_DebtSecuritiesAvailableForSaleAndCashAndCashEquivalents"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_89ee899b-a79a-4809-b049-ca76634816ea" xlink:to="loc_tars_DebtSecuritiesAvailableForSaleAndCashAndCashEquivalents_56beeca4-f86e-486a-9544-b82f80f13147" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_9dd60ad7-cb6a-4caf-91c4-b32867dbcbc3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_89ee899b-a79a-4809-b049-ca76634816ea" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_9dd60ad7-cb6a-4caf-91c4-b32867dbcbc3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiCurrentAndNoncurrent_e8850b0d-b5b2-49a6-9d51-7152dd374bb5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquitySecuritiesFvNiCurrentAndNoncurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_89ee899b-a79a-4809-b049-ca76634816ea" xlink:to="loc_us-gaap_EquitySecuritiesFvNiCurrentAndNoncurrent_e8850b0d-b5b2-49a6-9d51-7152dd374bb5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_EquityWarrantsFairValueDisclosure_63f17f1f-64ec-4ae2-9ea5-762d9822a1c4" xlink:href="tars-20220930.xsd#tars_EquityWarrantsFairValueDisclosure"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_89ee899b-a79a-4809-b049-ca76634816ea" xlink:to="loc_tars_EquityWarrantsFairValueDisclosure_63f17f1f-64ec-4ae2-9ea5-762d9822a1c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_7e280803-ae2a-4949-b3c4-1eec9d695cb3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_89ee899b-a79a-4809-b049-ca76634816ea" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_7e280803-ae2a-4949-b3c4-1eec9d695cb3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/FairValueMeasurementsAdditionalInformationDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#FairValueMeasurementsAdditionalInformationDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/FairValueMeasurementsAdditionalInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_dac2dec0-6b1b-4590-9898-ad24ed2c41f1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_WarrantAgreementNumberOfTranches_8816d4dd-5d46-4ef4-85d2-f6a5c9503ebd" xlink:href="tars-20220930.xsd#tars_WarrantAgreementNumberOfTranches"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_dac2dec0-6b1b-4590-9898-ad24ed2c41f1" xlink:to="loc_tars_WarrantAgreementNumberOfTranches_8816d4dd-5d46-4ef4-85d2-f6a5c9503ebd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_NumberOfVestedWarrants_feb0ea43-70f9-4026-a907-05416b97517f" xlink:href="tars-20220930.xsd#tars_NumberOfVestedWarrants"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_dac2dec0-6b1b-4590-9898-ad24ed2c41f1" xlink:to="loc_tars_NumberOfVestedWarrants_feb0ea43-70f9-4026-a907-05416b97517f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_NumberOfWarrants_a3f879df-012b-450a-8627-ef939660b020" xlink:href="tars-20220930.xsd#tars_NumberOfWarrants"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_dac2dec0-6b1b-4590-9898-ad24ed2c41f1" xlink:to="loc_tars_NumberOfWarrants_a3f879df-012b-450a-8627-ef939660b020" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_EquitySecuritiesFVNINumberOfShares_dba80551-4eb9-456d-84c3-45706dbb485a" xlink:href="tars-20220930.xsd#tars_EquitySecuritiesFVNINumberOfShares"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_dac2dec0-6b1b-4590-9898-ad24ed2c41f1" xlink:to="loc_tars_EquitySecuritiesFVNINumberOfShares_dba80551-4eb9-456d-84c3-45706dbb485a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/FairValueMeasurementsChangesinFairValueofEquityWarrantsDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#FairValueMeasurementsChangesinFairValueofEquityWarrantsDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/FairValueMeasurementsChangesinFairValueofEquityWarrantsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_d4ad5a60-4660-478c-9c63-e17552d4c214" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTable_bbbc65d7-b833-4931-8dd0-c005f864de6f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_d4ad5a60-4660-478c-9c63-e17552d4c214" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTable_bbbc65d7-b833-4931-8dd0-c005f864de6f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_239f2997-7191-44d8-a5cc-2bae683a157a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTable_bbbc65d7-b833-4931-8dd0-c005f864de6f" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_239f2997-7191-44d8-a5cc-2bae683a157a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_b54e8822-3985-45f8-9ef3-dcde1ae9b92e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_239f2997-7191-44d8-a5cc-2bae683a157a" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_b54e8822-3985-45f8-9ef3-dcde1ae9b92e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseMember_775ed50e-494b-468f-b104-06313e6612fe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NonoperatingIncomeExpenseMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_b54e8822-3985-45f8-9ef3-dcde1ae9b92e" xlink:to="loc_us-gaap_NonoperatingIncomeExpenseMember_775ed50e-494b-468f-b104-06313e6612fe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesMember_de7eea99-5b27-43f7-b2d0-23cb7ff3706e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SalesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_b54e8822-3985-45f8-9ef3-dcde1ae9b92e" xlink:to="loc_us-gaap_SalesMember_de7eea99-5b27-43f7-b2d0-23cb7ff3706e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_96e8d694-cce1-4453-9b0e-50606cad142e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationTable_bbbc65d7-b833-4931-8dd0-c005f864de6f" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_96e8d694-cce1-4453-9b0e-50606cad142e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_cc0a509f-16b6-4b0f-b2d0-3d1dfd2f1ad9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_96e8d694-cce1-4453-9b0e-50606cad142e" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_cc0a509f-16b6-4b0f-b2d0-3d1dfd2f1ad9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue_b5948d01-6113-43de-8791-2a99ddb14fad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_cc0a509f-16b6-4b0f-b2d0-3d1dfd2f1ad9" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue_b5948d01-6113-43de-8791-2a99ddb14fad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetGainLossIncludedInEarnings1_6fc57c54-699f-43c7-b93a-1e348233db81" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetGainLossIncludedInEarnings1"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_cc0a509f-16b6-4b0f-b2d0-3d1dfd2f1ad9" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetGainLossIncludedInEarnings1_6fc57c54-699f-43c7-b93a-1e348233db81" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue_4b1c8303-eb83-445b-880f-1d695828f6ce" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_cc0a509f-16b6-4b0f-b2d0-3d1dfd2f1ad9" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue_4b1c8303-eb83-445b-880f-1d695828f6ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/FairValueMeasurementsEstimatedValueofCashCashEquivalentsMarketableSecuritiesandEquitySecuritiesDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#FairValueMeasurementsEstimatedValueofCashCashEquivalentsMarketableSecuritiesandEquitySecuritiesDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/FairValueMeasurementsEstimatedValueofCashCashEquivalentsMarketableSecuritiesandEquitySecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_dc0668a9-feac-4e54-948d-5490441130cf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_dd2d7df5-6897-4bde-98e8-14e3abc4dd3c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_dc0668a9-feac-4e54-948d-5490441130cf" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_dd2d7df5-6897-4bde-98e8-14e3abc4dd3c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_665c7b81-62d2-46c6-8847-c2c4f49e623b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_dd2d7df5-6897-4bde-98e8-14e3abc4dd3c" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_665c7b81-62d2-46c6-8847-c2c4f49e623b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_3bfb66dc-3756-4cc2-82de-5bb3d73dced0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_665c7b81-62d2-46c6-8847-c2c4f49e623b" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_3bfb66dc-3756-4cc2-82de-5bb3d73dced0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesMember_c1f0b79d-38c9-4a25-b278-507bfacb3c18" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SalesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_3bfb66dc-3756-4cc2-82de-5bb3d73dced0" xlink:to="loc_us-gaap_SalesMember_c1f0b79d-38c9-4a25-b278-507bfacb3c18" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseMember_3672115e-e99b-4949-b8cb-9592fdfca05d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NonoperatingIncomeExpenseMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_3bfb66dc-3756-4cc2-82de-5bb3d73dced0" xlink:to="loc_us-gaap_NonoperatingIncomeExpenseMember_3672115e-e99b-4949-b8cb-9592fdfca05d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_6e1706df-9483-4a68-956e-06d201f8db01" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_dd2d7df5-6897-4bde-98e8-14e3abc4dd3c" xlink:to="loc_us-gaap_FinancialInstrumentAxis_6e1706df-9483-4a68-956e-06d201f8db01" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_0e329d6f-749b-4f92-8fbd-562b2b3358c1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_6e1706df-9483-4a68-956e-06d201f8db01" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_0e329d6f-749b-4f92-8fbd-562b2b3358c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_72ffbcb6-6c4b-42ca-b36b-d5f49e50d4b1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_0e329d6f-749b-4f92-8fbd-562b2b3358c1" xlink:to="loc_us-gaap_MoneyMarketFundsMember_72ffbcb6-6c4b-42ca-b36b-d5f49e50d4b1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_eeec6b3f-320d-49c6-83e3-165af8792ac3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_0e329d6f-749b-4f92-8fbd-562b2b3358c1" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_eeec6b3f-320d-49c6-83e3-165af8792ac3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_01d7d780-3f54-43a4-b4d2-fd3485ccd21f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommercialPaperMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_0e329d6f-749b-4f92-8fbd-562b2b3358c1" xlink:to="loc_us-gaap_CommercialPaperMember_01d7d780-3f54-43a4-b4d2-fd3485ccd21f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentDebtSecuritiesMember_e550b56b-5945-4c48-a96c-77e09d79a23f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USGovernmentDebtSecuritiesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_0e329d6f-749b-4f92-8fbd-562b2b3358c1" xlink:to="loc_us-gaap_USGovernmentDebtSecuritiesMember_e550b56b-5945-4c48-a96c-77e09d79a23f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_bf05676c-a8bb-45c8-a4cb-2cafc3ee29ee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_dd2d7df5-6897-4bde-98e8-14e3abc4dd3c" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_bf05676c-a8bb-45c8-a4cb-2cafc3ee29ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAbstract_f1a2fcf6-bcf7-4338-8f1d-fa6d4cf92954" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_bf05676c-a8bb-45c8-a4cb-2cafc3ee29ee" xlink:to="loc_us-gaap_CashAndCashEquivalentsAbstract_f1a2fcf6-bcf7-4338-8f1d-fa6d4cf92954" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_fb608be6-c054-473c-94a1-0675104f81dc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAbstract_f1a2fcf6-bcf7-4338-8f1d-fa6d4cf92954" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_fb608be6-c054-473c-94a1-0675104f81dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_CashAndCashEquivalentsAccumulatedUnrealizedGainsBeforeTax_9daa5a66-fe6b-46a1-bf81-f346158da414" xlink:href="tars-20220930.xsd#tars_CashAndCashEquivalentsAccumulatedUnrealizedGainsBeforeTax"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAbstract_f1a2fcf6-bcf7-4338-8f1d-fa6d4cf92954" xlink:to="loc_tars_CashAndCashEquivalentsAccumulatedUnrealizedGainsBeforeTax_9daa5a66-fe6b-46a1-bf81-f346158da414" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_0fb1905b-086d-4ec7-965e-2a7d23a4b38f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAbstract_f1a2fcf6-bcf7-4338-8f1d-fa6d4cf92954" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_0fb1905b-086d-4ec7-965e-2a7d23a4b38f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAbstract_6cd2a832-1b7f-4e40-80a2-d134f8be8621" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_bf05676c-a8bb-45c8-a4cb-2cafc3ee29ee" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAbstract_6cd2a832-1b7f-4e40-80a2-d134f8be8621" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_b8b679de-6e57-48a4-9dad-2b1d485aa456" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_6cd2a832-1b7f-4e40-80a2-d134f8be8621" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_b8b679de-6e57-48a4-9dad-2b1d485aa456" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_94f4c937-b412-416f-829f-dce75eef0c26" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_6cd2a832-1b7f-4e40-80a2-d134f8be8621" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_94f4c937-b412-416f-829f-dce75eef0c26" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_df727f1f-392b-465d-a4ea-0c212c1702b7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_6cd2a832-1b7f-4e40-80a2-d134f8be8621" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_df727f1f-392b-465d-a4ea-0c212c1702b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_289f7005-9a7e-41f9-8775-bfa216fc9129" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_6cd2a832-1b7f-4e40-80a2-d134f8be8621" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_289f7005-9a7e-41f9-8775-bfa216fc9129" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFVNIAbstract_9da68c13-61a5-49ca-a19d-6c99db58b233" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquitySecuritiesFVNIAbstract"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_bf05676c-a8bb-45c8-a4cb-2cafc3ee29ee" xlink:to="loc_us-gaap_EquitySecuritiesFVNIAbstract_9da68c13-61a5-49ca-a19d-6c99db58b233" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiCost_f6d07cb3-ff86-4b4c-b11f-73945bc1c6ca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquitySecuritiesFvNiCost"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquitySecuritiesFVNIAbstract_9da68c13-61a5-49ca-a19d-6c99db58b233" xlink:to="loc_us-gaap_EquitySecuritiesFvNiCost_f6d07cb3-ff86-4b4c-b11f-73945bc1c6ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGain_f4b50e55-feb4-4d6f-b17b-feb2085fdf21" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquitySecuritiesFvNiUnrealizedGain"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquitySecuritiesFVNIAbstract_9da68c13-61a5-49ca-a19d-6c99db58b233" xlink:to="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGain_f4b50e55-feb4-4d6f-b17b-feb2085fdf21" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiUnrealizedLoss_26fca6a0-dad7-425c-bb08-f5dba9a412de" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquitySecuritiesFvNiUnrealizedLoss"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquitySecuritiesFVNIAbstract_9da68c13-61a5-49ca-a19d-6c99db58b233" xlink:to="loc_us-gaap_EquitySecuritiesFvNiUnrealizedLoss_26fca6a0-dad7-425c-bb08-f5dba9a412de" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiCurrentAndNoncurrent_86cf4bb7-259a-4a1e-8bf7-0a9ae1ba7c2f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquitySecuritiesFvNiCurrentAndNoncurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquitySecuritiesFVNIAbstract_9da68c13-61a5-49ca-a19d-6c99db58b233" xlink:to="loc_us-gaap_EquitySecuritiesFvNiCurrentAndNoncurrent_86cf4bb7-259a-4a1e-8bf7-0a9ae1ba7c2f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/CommitmentContingenciesFacilityLeasesDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#CommitmentContingenciesFacilityLeasesDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/CommitmentContingenciesFacilityLeasesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_7a3fa78e-f9b1-4ff4-bb9b-cd688d77cfdd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionTable_7a16c956-d4d8-4bcc-b621-70e4b57ca656" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeLeaseDescriptionTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_7a3fa78e-f9b1-4ff4-bb9b-cd688d77cfdd" xlink:to="loc_us-gaap_LesseeLeaseDescriptionTable_7a16c956-d4d8-4bcc-b621-70e4b57ca656" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermAxis_eb4d65ab-3cc5-49b3-ba74-b0031c7e9b54" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseContractualTermAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_7a16c956-d4d8-4bcc-b621-70e4b57ca656" xlink:to="loc_us-gaap_LeaseContractualTermAxis_eb4d65ab-3cc5-49b3-ba74-b0031c7e9b54" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseContractualTermDomain_e1507870-831b-407a-bbe0-048d61862764" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseContractualTermDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeaseContractualTermAxis_eb4d65ab-3cc5-49b3-ba74-b0031c7e9b54" xlink:to="loc_us-gaap_LeaseContractualTermDomain_e1507870-831b-407a-bbe0-048d61862764" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_IrvineOfficeAndFacilitiesLeaseMember_d9447fa6-77f9-4f1a-a4bb-7b2dcb2f56f4" xlink:href="tars-20220930.xsd#tars_IrvineOfficeAndFacilitiesLeaseMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeaseContractualTermDomain_e1507870-831b-407a-bbe0-048d61862764" xlink:to="loc_tars_IrvineOfficeAndFacilitiesLeaseMember_d9447fa6-77f9-4f1a-a4bb-7b2dcb2f56f4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionLineItems_f498faf0-1f72-4946-8b3f-be7a8607868d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeLeaseDescriptionLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_7a16c956-d4d8-4bcc-b621-70e4b57ca656" xlink:to="loc_us-gaap_LesseeLeaseDescriptionLineItems_f498faf0-1f72-4946-8b3f-be7a8607868d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_LesseeOperatingLeaseNumberOfLeaseContracts_ed3c8050-b80a-4f00-9141-5acf12a6badb" xlink:href="tars-20220930.xsd#tars_LesseeOperatingLeaseNumberOfLeaseContracts"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_f498faf0-1f72-4946-8b3f-be7a8607868d" xlink:to="loc_tars_LesseeOperatingLeaseNumberOfLeaseContracts_ed3c8050-b80a-4f00-9141-5acf12a6badb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_230d8fc9-f4a6-4b30-857e-dea8e63a796c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_f498faf0-1f72-4946-8b3f-be7a8607868d" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_230d8fc9-f4a6-4b30-857e-dea8e63a796c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1_599bd7d8-b544-440e-b273-b5138dce0c8d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_f498faf0-1f72-4946-8b3f-be7a8607868d" xlink:to="loc_us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1_599bd7d8-b544-440e-b273-b5138dce0c8d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent_eb96e235-624a-4c25-aba7-bc91b5842358" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_f498faf0-1f72-4946-8b3f-be7a8607868d" xlink:to="loc_us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent_eb96e235-624a-4c25-aba7-bc91b5842358" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/CommitmentContingenciesLeaseAssetandLiabilityAccountsDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#CommitmentContingenciesLeaseAssetandLiabilityAccountsDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/CommitmentContingenciesLeaseAssetandLiabilityAccountsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_50b8153e-f496-4e57-b9ed-e583e9a89600" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_5a12e748-eda7-4a56-982c-5fcab74797cc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_50b8153e-f496-4e57-b9ed-e583e9a89600" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_5a12e748-eda7-4a56-982c-5fcab74797cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_b15ac1b6-ed1f-4ca2-8a0e-d08cfa53d3b5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_50b8153e-f496-4e57-b9ed-e583e9a89600" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_b15ac1b6-ed1f-4ca2-8a0e-d08cfa53d3b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrentStatementOfFinancialPositionExtensibleList_f1595aa7-f474-47ed-9258-f4e79215f319" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityCurrentStatementOfFinancialPositionExtensibleList"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeaseLiabilityCurrent_b15ac1b6-ed1f-4ca2-8a0e-d08cfa53d3b5" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrentStatementOfFinancialPositionExtensibleList_f1595aa7-f474-47ed-9258-f4e79215f319" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_34e390b4-5070-4353-a384-8972ef3f0ae4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_50b8153e-f496-4e57-b9ed-e583e9a89600" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_34e390b4-5070-4353-a384-8972ef3f0ae4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrentStatementOfFinancialPositionExtensibleList_1834af11-cc05-43d9-841b-c8f8c9d236e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityNoncurrentStatementOfFinancialPositionExtensibleList"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_34e390b4-5070-4353-a384-8972ef3f0ae4" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrentStatementOfFinancialPositionExtensibleList_1834af11-cc05-43d9-841b-c8f8c9d236e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_5003fc80-ac82-449c-8db9-6be453e31c31" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_50b8153e-f496-4e57-b9ed-e583e9a89600" xlink:to="loc_us-gaap_OperatingLeaseLiability_5003fc80-ac82-449c-8db9-6be453e31c31" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/CommitmentContingenciesLeaseCostDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#CommitmentContingenciesLeaseCostDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/CommitmentContingenciesLeaseCostDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_2bd3ced5-09da-4bdf-8502-04ed0522cb89" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseCost_fcd1d89b-af4b-4401-8eb1-aeca3445359a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseCost"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_2bd3ced5-09da-4bdf-8502-04ed0522cb89" xlink:to="loc_us-gaap_OperatingLeaseCost_fcd1d89b-af4b-4401-8eb1-aeca3445359a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableLeaseCost_2296c5d3-2537-4c6e-9893-2ab9c43d8396" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableLeaseCost"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_2bd3ced5-09da-4bdf-8502-04ed0522cb89" xlink:to="loc_us-gaap_VariableLeaseCost_2296c5d3-2537-4c6e-9893-2ab9c43d8396" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermLeaseCost_434438f3-369e-43fc-b406-aa23f020bc4f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShortTermLeaseCost"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_2bd3ced5-09da-4bdf-8502-04ed0522cb89" xlink:to="loc_us-gaap_ShortTermLeaseCost_434438f3-369e-43fc-b406-aa23f020bc4f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCost_8d8a5161-7599-42bc-b273-50d25c259a29" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseCost"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_2bd3ced5-09da-4bdf-8502-04ed0522cb89" xlink:to="loc_us-gaap_LeaseCost_8d8a5161-7599-42bc-b273-50d25c259a29" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/CommitmentandContingenciesSummaryofMinimumLeasePaymentsDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#CommitmentandContingenciesSummaryofMinimumLeasePaymentsDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/CommitmentandContingenciesSummaryofMinimumLeasePaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_8ae77ea7-c703-42ee-9628-e6f960461852" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_3613388e-b221-42ca-8353-86bb048c05f5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_8ae77ea7-c703-42ee-9628-e6f960461852" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_3613388e-b221-42ca-8353-86bb048c05f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_a220a0d5-5e45-439b-a7d3-dd813ab8c77b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_8ae77ea7-c703-42ee-9628-e6f960461852" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_a220a0d5-5e45-439b-a7d3-dd813ab8c77b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_6ebfd60a-fcc9-4daf-8ae7-c2b2eb3e704b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_8ae77ea7-c703-42ee-9628-e6f960461852" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_6ebfd60a-fcc9-4daf-8ae7-c2b2eb3e704b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_db821768-9aaa-49b6-8ac3-a3d824a28596" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_8ae77ea7-c703-42ee-9628-e6f960461852" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_db821768-9aaa-49b6-8ac3-a3d824a28596" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_51114e16-9717-4efb-a33e-997c626ffe7c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_8ae77ea7-c703-42ee-9628-e6f960461852" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_51114e16-9717-4efb-a33e-997c626ffe7c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_8e25605b-7a68-4c82-9494-36e27fd3c312" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_8ae77ea7-c703-42ee-9628-e6f960461852" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_8e25605b-7a68-4c82-9494-36e27fd3c312" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_40d47218-bd63-4811-a87e-a18746c7ddab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_8ae77ea7-c703-42ee-9628-e6f960461852" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_40d47218-bd63-4811-a87e-a18746c7ddab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_df90bee2-9224-4f2b-8d69-4ade6b5d14c6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_8ae77ea7-c703-42ee-9628-e6f960461852" xlink:to="loc_us-gaap_OperatingLeaseLiability_df90bee2-9224-4f2b-8d69-4ade6b5d14c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/CommitmentandContingenciesSummaryofMinimumLeasePaymentsDetails_1" xlink:type="simple" xlink:href="tars-20220930.xsd#CommitmentandContingenciesSummaryofMinimumLeasePaymentsDetails_1"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/CommitmentandContingenciesSummaryofMinimumLeasePaymentsDetails_1" xlink:type="extended"/>
  <link:roleRef roleURI="http://tarsusrx.com/role/CommitmentContingenciesInLicenseAgreementforLotilanerDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#CommitmentContingenciesInLicenseAgreementforLotilanerDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/CommitmentContingenciesInLicenseAgreementforLotilanerDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_98f872b5-1640-4002-a58e-4fef0009e5e8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_62564919-cc52-4f5d-bae0-e0656106ac9b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_98f872b5-1640-4002-a58e-4fef0009e5e8" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_62564919-cc52-4f5d-bae0-e0656106ac9b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_4aa0e2cf-a79d-4ed3-b819-ac03a78f9067" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_62564919-cc52-4f5d-bae0-e0656106ac9b" xlink:to="loc_us-gaap_TypeOfArrangementAxis_4aa0e2cf-a79d-4ed3-b819-ac03a78f9067" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_b37b20a4-5466-44c8-8b42-00aaa43f42ef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_4aa0e2cf-a79d-4ed3-b819-ac03a78f9067" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_b37b20a4-5466-44c8-8b42-00aaa43f42ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementTransactionWithPartyToCollaborativeArrangementMember_dc808fb7-5e36-426a-9f98-e29a60886591" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollaborativeArrangementTransactionWithPartyToCollaborativeArrangementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_b37b20a4-5466-44c8-8b42-00aaa43f42ef" xlink:to="loc_us-gaap_CollaborativeArrangementTransactionWithPartyToCollaborativeArrangementMember_dc808fb7-5e36-426a-9f98-e29a60886591" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_b4ab73d6-3063-466a-b524-9eb5211ad19b" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_62564919-cc52-4f5d-bae0-e0656106ac9b" xlink:to="loc_srt_ProductOrServiceAxis_b4ab73d6-3063-466a-b524-9eb5211ad19b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_6026c244-7761-4a5a-8179-936481300f4c" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_b4ab73d6-3063-466a-b524-9eb5211ad19b" xlink:to="loc_srt_ProductsAndServicesDomain_6026c244-7761-4a5a-8179-936481300f4c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_ClinicalMilestonesMember_dfab2498-e8a8-423a-a336-72750a4833bf" xlink:href="tars-20220930.xsd#tars_ClinicalMilestonesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_6026c244-7761-4a5a-8179-936481300f4c" xlink:to="loc_tars_ClinicalMilestonesMember_dfab2498-e8a8-423a-a336-72750a4833bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_CommercialAndSalesMilestonesMember_f2999192-77a7-4832-9290-19b6e8d95722" xlink:href="tars-20220930.xsd#tars_CommercialAndSalesMilestonesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_6026c244-7761-4a5a-8179-936481300f4c" xlink:to="loc_tars_CommercialAndSalesMilestonesMember_f2999192-77a7-4832-9290-19b6e8d95722" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_4a26e718-6b91-47c5-a035-080862062621" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_62564919-cc52-4f5d-bae0-e0656106ac9b" xlink:to="loc_srt_CounterpartyNameAxis_4a26e718-6b91-47c5-a035-080862062621" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_e74fc3ad-577b-4a72-96bf-01261388ed1a" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_4a26e718-6b91-47c5-a035-080862062621" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_e74fc3ad-577b-4a72-96bf-01261388ed1a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_LianBioMember_94720da5-16c3-4188-b2a4-0e908e7561e6" xlink:href="tars-20220930.xsd#tars_LianBioMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_e74fc3ad-577b-4a72-96bf-01261388ed1a" xlink:to="loc_tars_LianBioMember_94720da5-16c3-4188-b2a4-0e908e7561e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_ElancoMember_a821d560-61af-4ec7-a609-d41fae0d893e" xlink:href="tars-20220930.xsd#tars_ElancoMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_e74fc3ad-577b-4a72-96bf-01261388ed1a" xlink:to="loc_tars_ElancoMember_a821d560-61af-4ec7-a609-d41fae0d893e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0c68e0f4-e9f3-487b-be21-1e5e7feeeeb7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_62564919-cc52-4f5d-bae0-e0656106ac9b" xlink:to="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0c68e0f4-e9f3-487b-be21-1e5e7feeeeb7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_0937e46d-0552-4ecf-a2cc-586b7f244167" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0c68e0f4-e9f3-487b-be21-1e5e7feeeeb7" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_0937e46d-0552-4ecf-a2cc-586b7f244167" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_UpfrontPayment_211edf99-9308-46a9-bbb0-a59530f808d3" xlink:href="tars-20220930.xsd#tars_UpfrontPayment"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0c68e0f4-e9f3-487b-be21-1e5e7feeeeb7" xlink:to="loc_tars_UpfrontPayment_211edf99-9308-46a9-bbb0-a59530f808d3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_CollaborativeArrangementMaximumMilestonePayment_c727e924-d679-455a-99c4-81e0c01c8e70" xlink:href="tars-20220930.xsd#tars_CollaborativeArrangementMaximumMilestonePayment"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0c68e0f4-e9f3-487b-be21-1e5e7feeeeb7" xlink:to="loc_tars_CollaborativeArrangementMaximumMilestonePayment_c727e924-d679-455a-99c4-81e0c01c8e70" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesIssuedForServices_e65c5fae-ddd3-418e-a7e0-56dd0a86ceac" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesIssuedForServices"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0c68e0f4-e9f3-487b-be21-1e5e7feeeeb7" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesIssuedForServices_e65c5fae-ddd3-418e-a7e0-56dd0a86ceac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueIssuedForServices_71b2cde2-c42f-4ca7-8f4c-ce27777ff3cf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueIssuedForServices"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0c68e0f4-e9f3-487b-be21-1e5e7feeeeb7" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueIssuedForServices_71b2cde2-c42f-4ca7-8f4c-ce27777ff3cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharePrice_de95a775-e03b-46cb-a02f-c2bb94d5e1a2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharePrice"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0c68e0f4-e9f3-487b-be21-1e5e7feeeeb7" xlink:to="loc_us-gaap_SharePrice_de95a775-e03b-46cb-a02f-c2bb94d5e1a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_AdditionalStockToBeIssuedOnEighteenMonthAgreementAnniversarySharesIssuedForServices_954cac64-d700-4cb4-9a55-18a28b25c9d3" xlink:href="tars-20220930.xsd#tars_AdditionalStockToBeIssuedOnEighteenMonthAgreementAnniversarySharesIssuedForServices"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0c68e0f4-e9f3-487b-be21-1e5e7feeeeb7" xlink:to="loc_tars_AdditionalStockToBeIssuedOnEighteenMonthAgreementAnniversarySharesIssuedForServices_954cac64-d700-4cb4-9a55-18a28b25c9d3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_AdditionalStockToBeIssuedOnEighteenMonthAgreementAnniversaryValueIssuedForServices_05ce7e94-89cd-45be-895a-b91884ccdd57" xlink:href="tars-20220930.xsd#tars_AdditionalStockToBeIssuedOnEighteenMonthAgreementAnniversaryValueIssuedForServices"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0c68e0f4-e9f3-487b-be21-1e5e7feeeeb7" xlink:to="loc_tars_AdditionalStockToBeIssuedOnEighteenMonthAgreementAnniversaryValueIssuedForServices_05ce7e94-89cd-45be-895a-b91884ccdd57" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_AdditionalStockToBeIssuedOnEighteenMonthAgreementAnniversarySharePriceIssuedForServices_dd6fff3f-7b22-47e2-b867-b15217c22814" xlink:href="tars-20220930.xsd#tars_AdditionalStockToBeIssuedOnEighteenMonthAgreementAnniversarySharePriceIssuedForServices"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0c68e0f4-e9f3-487b-be21-1e5e7feeeeb7" xlink:to="loc_tars_AdditionalStockToBeIssuedOnEighteenMonthAgreementAnniversarySharePriceIssuedForServices_dd6fff3f-7b22-47e2-b867-b15217c22814" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/CommitmentContingenciesEmploymentArrangementsDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#CommitmentContingenciesEmploymentArrangementsDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/CommitmentContingenciesEmploymentArrangementsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_b6a79e4d-3534-448a-9b5a-ac90d78c6dd4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_NumberOfEmploymentArrangementsWithExecutiveOfficers_d8a8913e-ee5a-45c2-a01b-701f94e71daa" xlink:href="tars-20220930.xsd#tars_NumberOfEmploymentArrangementsWithExecutiveOfficers"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_b6a79e4d-3534-448a-9b5a-ac90d78c6dd4" xlink:to="loc_tars_NumberOfEmploymentArrangementsWithExecutiveOfficers_d8a8913e-ee5a-45c2-a01b-701f94e71daa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/OutLicenseAgreementDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#OutLicenseAgreementDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/OutLicenseAgreementDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_b7551755-2ed7-4cc1-a7cc-835d183564d3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_bb02ae0d-acf1-485e-b782-72565b185784" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_b7551755-2ed7-4cc1-a7cc-835d183564d3" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_bb02ae0d-acf1-485e-b782-72565b185784" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_14d3e6c4-091a-47e9-9a11-c70e4b4b4c64" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_bb02ae0d-acf1-485e-b782-72565b185784" xlink:to="loc_srt_CounterpartyNameAxis_14d3e6c4-091a-47e9-9a11-c70e4b4b4c64" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_7473add0-8d5e-46b5-b0f7-c28231904d3a" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_14d3e6c4-091a-47e9-9a11-c70e4b4b4c64" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_7473add0-8d5e-46b5-b0f7-c28231904d3a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_LianBioMember_2e9e460b-906f-42b4-aea0-06d02b81f7ff" xlink:href="tars-20220930.xsd#tars_LianBioMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_7473add0-8d5e-46b5-b0f7-c28231904d3a" xlink:to="loc_tars_LianBioMember_2e9e460b-906f-42b4-aea0-06d02b81f7ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_bfe4d4a8-3a08-4858-9a82-fd186c039225" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_bb02ae0d-acf1-485e-b782-72565b185784" xlink:to="loc_us-gaap_TypeOfArrangementAxis_bfe4d4a8-3a08-4858-9a82-fd186c039225" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_a51d8de0-6326-41be-a5fb-73a73136857e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_bfe4d4a8-3a08-4858-9a82-fd186c039225" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_a51d8de0-6326-41be-a5fb-73a73136857e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementTransactionWithPartyToCollaborativeArrangementMember_bb4adcc5-b0b2-4fc0-a542-88067db1b73e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollaborativeArrangementTransactionWithPartyToCollaborativeArrangementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_a51d8de0-6326-41be-a5fb-73a73136857e" xlink:to="loc_us-gaap_CollaborativeArrangementTransactionWithPartyToCollaborativeArrangementMember_bb4adcc5-b0b2-4fc0-a542-88067db1b73e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_5fe910ee-04aa-4825-9088-49d64b063e25" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_bb02ae0d-acf1-485e-b782-72565b185784" xlink:to="loc_srt_ProductOrServiceAxis_5fe910ee-04aa-4825-9088-49d64b063e25" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_fe3efdf7-dcaf-4217-b8ed-8288be17f03f" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_5fe910ee-04aa-4825-9088-49d64b063e25" xlink:to="loc_srt_ProductsAndServicesDomain_fe3efdf7-dcaf-4217-b8ed-8288be17f03f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_ClinicalDevelopmentMilestonesMember_22ca1edf-ec5d-46a8-a096-0f064376be50" xlink:href="tars-20220930.xsd#tars_ClinicalDevelopmentMilestonesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_fe3efdf7-dcaf-4217-b8ed-8288be17f03f" xlink:to="loc_tars_ClinicalDevelopmentMilestonesMember_22ca1edf-ec5d-46a8-a096-0f064376be50" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_DevelopmentAndRegulatoryMilestoneMember_ae1538db-f618-4973-8a47-c79370a8f1f2" xlink:href="tars-20220930.xsd#tars_DevelopmentAndRegulatoryMilestoneMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_fe3efdf7-dcaf-4217-b8ed-8288be17f03f" xlink:to="loc_tars_DevelopmentAndRegulatoryMilestoneMember_ae1538db-f618-4973-8a47-c79370a8f1f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_DrugSupplyAgreementMilestoneMember_c31b4ea6-cdf4-48a4-b0e6-f5abc5221a8f" xlink:href="tars-20220930.xsd#tars_DrugSupplyAgreementMilestoneMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_fe3efdf7-dcaf-4217-b8ed-8288be17f03f" xlink:to="loc_tars_DrugSupplyAgreementMilestoneMember_c31b4ea6-cdf4-48a4-b0e6-f5abc5221a8f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_SalesMilestoneMember_b6ec27a8-625a-4e35-ad2d-af4db05d32a2" xlink:href="tars-20220930.xsd#tars_SalesMilestoneMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_fe3efdf7-dcaf-4217-b8ed-8288be17f03f" xlink:to="loc_tars_SalesMilestoneMember_b6ec27a8-625a-4e35-ad2d-af4db05d32a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_341ebefb-27d3-4795-9e24-6dab7f570e1b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_bb02ae0d-acf1-485e-b782-72565b185784" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_341ebefb-27d3-4795-9e24-6dab7f570e1b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_0936fdea-7f45-4114-9eaf-766be43576ab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_341ebefb-27d3-4795-9e24-6dab7f570e1b" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_0936fdea-7f45-4114-9eaf-766be43576ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_9d70369b-b9f4-4d46-9a58-202535775119" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_0936fdea-7f45-4114-9eaf-766be43576ab" xlink:to="loc_us-gaap_SubsequentEventMember_9d70369b-b9f4-4d46-9a58-202535775119" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_a7b90e55-396e-4525-b1ed-3d8958f327d0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_bb02ae0d-acf1-485e-b782-72565b185784" xlink:to="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_a7b90e55-396e-4525-b1ed-3d8958f327d0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_UpfrontPayment_7ffcb452-8123-4af9-aefa-c8b2fe436cdb" xlink:href="tars-20220930.xsd#tars_UpfrontPayment"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_a7b90e55-396e-4525-b1ed-3d8958f327d0" xlink:to="loc_tars_UpfrontPayment_7ffcb452-8123-4af9-aefa-c8b2fe436cdb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_CollaborativeArrangementMilestonePayment_fb718d48-1b37-4947-a716-ca4173e92af5" xlink:href="tars-20220930.xsd#tars_CollaborativeArrangementMilestonePayment"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_a7b90e55-396e-4525-b1ed-3d8958f327d0" xlink:to="loc_tars_CollaborativeArrangementMilestonePayment_fb718d48-1b37-4947-a716-ca4173e92af5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_CollaborativeArrangementMaximumMilestonePayment_5dfafaf1-6343-4426-8802-41893b83da78" xlink:href="tars-20220930.xsd#tars_CollaborativeArrangementMaximumMilestonePayment"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_a7b90e55-396e-4525-b1ed-3d8958f327d0" xlink:to="loc_tars_CollaborativeArrangementMaximumMilestonePayment_5dfafaf1-6343-4426-8802-41893b83da78" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/CreditFacilityAgreementDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#CreditFacilityAgreementDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/CreditFacilityAgreementDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_74ccc6d3-d4f6-43e2-b840-84e51001b305" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_72c764a2-309f-4cad-a9e4-0a338fc2a156" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_74ccc6d3-d4f6-43e2-b840-84e51001b305" xlink:to="loc_us-gaap_DebtInstrumentTable_72c764a2-309f-4cad-a9e4-0a338fc2a156" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_97138c3a-067e-49df-8d12-9b24046b0d93" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_72c764a2-309f-4cad-a9e4-0a338fc2a156" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_97138c3a-067e-49df-8d12-9b24046b0d93" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_5ce1d740-4066-4650-92cb-582a1ae71ead" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_97138c3a-067e-49df-8d12-9b24046b0d93" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_5ce1d740-4066-4650-92cb-582a1ae71ead" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_6968ae61-7ac0-414b-9d6c-9b637a4e83fc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_5ce1d740-4066-4650-92cb-582a1ae71ead" xlink:to="loc_us-gaap_LineOfCreditMember_6968ae61-7ac0-414b-9d6c-9b637a4e83fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_6699492a-585a-4146-8035-f887ea059c31" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_72c764a2-309f-4cad-a9e4-0a338fc2a156" xlink:to="loc_us-gaap_DebtInstrumentAxis_6699492a-585a-4146-8035-f887ea059c31" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_25ab4284-021e-44ca-94d1-7871611d57d2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_6699492a-585a-4146-8035-f887ea059c31" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_25ab4284-021e-44ca-94d1-7871611d57d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_CreditFacilityTrancheOneMember_8d0e1b0f-d94f-4bc5-8092-aff7bc0e09b2" xlink:href="tars-20220930.xsd#tars_CreditFacilityTrancheOneMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_25ab4284-021e-44ca-94d1-7871611d57d2" xlink:to="loc_tars_CreditFacilityTrancheOneMember_8d0e1b0f-d94f-4bc5-8092-aff7bc0e09b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_CreditFacilityTrancheTwoMember_887f9c29-23ac-47ec-94a5-a66c271a9078" xlink:href="tars-20220930.xsd#tars_CreditFacilityTrancheTwoMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_25ab4284-021e-44ca-94d1-7871611d57d2" xlink:to="loc_tars_CreditFacilityTrancheTwoMember_887f9c29-23ac-47ec-94a5-a66c271a9078" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_CreditFacilityTrancheThreeMember_5958d937-b8af-43a8-95b1-5ad4326d76da" xlink:href="tars-20220930.xsd#tars_CreditFacilityTrancheThreeMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_25ab4284-021e-44ca-94d1-7871611d57d2" xlink:to="loc_tars_CreditFacilityTrancheThreeMember_5958d937-b8af-43a8-95b1-5ad4326d76da" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_CreditFacilityTrancheFourMember_de29e62b-f631-4ba8-8188-d7cc2cd48bf9" xlink:href="tars-20220930.xsd#tars_CreditFacilityTrancheFourMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_25ab4284-021e-44ca-94d1-7871611d57d2" xlink:to="loc_tars_CreditFacilityTrancheFourMember_de29e62b-f631-4ba8-8188-d7cc2cd48bf9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_CreditFacilityTrancheFiveMember_6c8fe032-3fb1-4dfa-a6d9-cbcadcc300dd" xlink:href="tars-20220930.xsd#tars_CreditFacilityTrancheFiveMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_25ab4284-021e-44ca-94d1-7871611d57d2" xlink:to="loc_tars_CreditFacilityTrancheFiveMember_6c8fe032-3fb1-4dfa-a6d9-cbcadcc300dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_CreditFacilityTrancheSixMember_f8f82fcb-ce61-4d96-905c-4c0af00c2335" xlink:href="tars-20220930.xsd#tars_CreditFacilityTrancheSixMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_25ab4284-021e-44ca-94d1-7871611d57d2" xlink:to="loc_tars_CreditFacilityTrancheSixMember_f8f82fcb-ce61-4d96-905c-4c0af00c2335" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateAxis_d3c07d30-1595-4875-8a94-22696197e4e6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableRateAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_72c764a2-309f-4cad-a9e4-0a338fc2a156" xlink:to="loc_us-gaap_VariableRateAxis_d3c07d30-1595-4875-8a94-22696197e4e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_35baaef0-908a-475a-a766-637761125c7a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableRateDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateAxis_d3c07d30-1595-4875-8a94-22696197e4e6" xlink:to="loc_us-gaap_VariableRateDomain_35baaef0-908a-475a-a766-637761125c7a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrimeRateMember_fc856e89-efac-4e64-8876-f356563f437e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrimeRateMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateDomain_35baaef0-908a-475a-a766-637761125c7a" xlink:to="loc_us-gaap_PrimeRateMember_fc856e89-efac-4e64-8876-f356563f437e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_6142c348-8fdb-4216-a410-d061bc957443" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_72c764a2-309f-4cad-a9e4-0a338fc2a156" xlink:to="loc_us-gaap_DebtInstrumentLineItems_6142c348-8fdb-4216-a410-d061bc957443" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_63187369-50ef-41ac-bd30-1cdc6474e19a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6142c348-8fdb-4216-a410-d061bc957443" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_63187369-50ef-41ac-bd30-1cdc6474e19a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_LineOfCreditFacilityDrawDownIncrements_af66cfd7-ce24-4e62-8f88-6893dfa897c7" xlink:href="tars-20220930.xsd#tars_LineOfCreditFacilityDrawDownIncrements"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6142c348-8fdb-4216-a410-d061bc957443" xlink:to="loc_tars_LineOfCreditFacilityDrawDownIncrements_af66cfd7-ce24-4e62-8f88-6893dfa897c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_1beac0e6-59c5-4bf6-b5b5-661866df0f4b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6142c348-8fdb-4216-a410-d061bc957443" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_1beac0e6-59c5-4bf6-b5b5-661866df0f4b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_2dfd72dd-b6dc-4961-a86e-06b3b9989a7a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6142c348-8fdb-4216-a410-d061bc957443" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_2dfd72dd-b6dc-4961-a86e-06b3b9989a7a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityInterestRateDuringPeriod_81afa0d8-2e91-4bee-9ac1-f6ff8a1b38dc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityInterestRateDuringPeriod"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6142c348-8fdb-4216-a410-d061bc957443" xlink:to="loc_us-gaap_LineOfCreditFacilityInterestRateDuringPeriod_81afa0d8-2e91-4bee-9ac1-f6ff8a1b38dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_89217210-4c49-4ecb-ae46-7d7965a20c45" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6142c348-8fdb-4216-a410-d061bc957443" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_89217210-4c49-4ecb-ae46-7d7965a20c45" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityPeriodicPaymentInterest_9dd2647d-96bb-487a-a9a1-457e6ab28438" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityPeriodicPaymentInterest"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6142c348-8fdb-4216-a410-d061bc957443" xlink:to="loc_us-gaap_LineOfCreditFacilityPeriodicPaymentInterest_9dd2647d-96bb-487a-a9a1-457e6ab28438" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_LineOfCreditFacilityPeriodicPaymentInterestRate_33a74591-7e6e-47cc-9739-72413aee8f89" xlink:href="tars-20220930.xsd#tars_LineOfCreditFacilityPeriodicPaymentInterestRate"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6142c348-8fdb-4216-a410-d061bc957443" xlink:to="loc_tars_LineOfCreditFacilityPeriodicPaymentInterestRate_33a74591-7e6e-47cc-9739-72413aee8f89" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtIssuanceCostsLineOfCreditArrangementsNet_0f404b78-d0a2-4266-90f8-b7a8f7d1b91b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtIssuanceCostsLineOfCreditArrangementsNet"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6142c348-8fdb-4216-a410-d061bc957443" xlink:to="loc_us-gaap_DebtIssuanceCostsLineOfCreditArrangementsNet_0f404b78-d0a2-4266-90f8-b7a8f7d1b91b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_8b8d375f-44db-444e-adf5-f383dbfb3284" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_6142c348-8fdb-4216-a410-d061bc957443" xlink:to="loc_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_8b8d375f-44db-444e-adf5-f383dbfb3284" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/CreditFacilityAgreementSummaryofInterestExpenseDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#CreditFacilityAgreementSummaryofInterestExpenseDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/CreditFacilityAgreementSummaryofInterestExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_b9ba6ebd-bdd7-4a59-8a8b-3465a5e27a80" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDebtExcludingAmortization_f498a196-eff3-42ac-bd1a-c373cf30fdbb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpenseDebtExcludingAmortization"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_b9ba6ebd-bdd7-4a59-8a8b-3465a5e27a80" xlink:to="loc_us-gaap_InterestExpenseDebtExcludingAmortization_f498a196-eff3-42ac-bd1a-c373cf30fdbb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfDebtDiscountPremium_ce7f4daa-9122-46c5-8b3b-f3aade8a8e54" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfDebtDiscountPremium"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_b9ba6ebd-bdd7-4a59-8a8b-3465a5e27a80" xlink:to="loc_us-gaap_AmortizationOfDebtDiscountPremium_ce7f4daa-9122-46c5-8b3b-f3aade8a8e54" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_92cd40b1-6523-41c2-92d3-13e3c125ea37" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_b9ba6ebd-bdd7-4a59-8a8b-3465a5e27a80" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_92cd40b1-6523-41c2-92d3-13e3c125ea37" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDebt_8450c934-56fc-4ff7-b7e7-17f1e9cf1db2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpenseDebt"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_b9ba6ebd-bdd7-4a59-8a8b-3465a5e27a80" xlink:to="loc_us-gaap_InterestExpenseDebt_8450c934-56fc-4ff7-b7e7-17f1e9cf1db2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/CreditFacilityAgreementBalancesofDebtDebtIssuanceCostsandAccumulatedAccretionDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#CreditFacilityAgreementBalancesofDebtDebtIssuanceCostsandAccumulatedAccretionDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/CreditFacilityAgreementBalancesofDebtDebtIssuanceCostsandAccumulatedAccretionDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_02a106f1-e250-49d3-99df-e5f273b07803" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_92b4f91c-77e4-472b-8f94-f71dc4641007" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_02a106f1-e250-49d3-99df-e5f273b07803" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_92b4f91c-77e4-472b-8f94-f71dc4641007" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtIssuanceCostsLineOfCreditArrangementsNet_7b35f008-5544-487b-b656-2754c4070baf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtIssuanceCostsLineOfCreditArrangementsNet"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_02a106f1-e250-49d3-99df-e5f273b07803" xlink:to="loc_us-gaap_DebtIssuanceCostsLineOfCreditArrangementsNet_7b35f008-5544-487b-b656-2754c4070baf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet_67296fef-dae3-4398-b41d-b3c277276d2c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_02a106f1-e250-49d3-99df-e5f273b07803" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumNet_67296fef-dae3-4398-b41d-b3c277276d2c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedAmortizationDeferredFinanceCosts_cfbedaf4-1cf5-459e-b2fb-a8e90d9d9529" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedAmortizationDeferredFinanceCosts"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_02a106f1-e250-49d3-99df-e5f273b07803" xlink:to="loc_us-gaap_AccumulatedAmortizationDeferredFinanceCosts_cfbedaf4-1cf5-459e-b2fb-a8e90d9d9529" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_bb61c065-cd34-43bd-9a28-517e2bc46b06" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebt"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_02a106f1-e250-49d3-99df-e5f273b07803" xlink:to="loc_us-gaap_LongTermDebt_bb61c065-cd34-43bd-9a28-517e2bc46b06" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://tarsusrx.com/role/SubsequentEventDetails" xlink:type="simple" xlink:href="tars-20220930.xsd#SubsequentEventDetails"/>
  <link:presentationLink xlink:role="http://tarsusrx.com/role/SubsequentEventDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventsAbstract_8b093253-fe33-436d-b221-68140541709d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTable_dd7ead74-0566-496e-8df6-ff86c11924c1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventsAbstract_8b093253-fe33-436d-b221-68140541709d" xlink:to="loc_us-gaap_SubsequentEventTable_dd7ead74-0566-496e-8df6-ff86c11924c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_e16070d8-75fb-4f60-9516-140f96bbd4a0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_dd7ead74-0566-496e-8df6-ff86c11924c1" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_e16070d8-75fb-4f60-9516-140f96bbd4a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_182cacae-12ac-4be6-a1c2-e33129d5819e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_e16070d8-75fb-4f60-9516-140f96bbd4a0" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_182cacae-12ac-4be6-a1c2-e33129d5819e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_12a94de3-1417-4239-8ec1-e1e53ba86a6e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_182cacae-12ac-4be6-a1c2-e33129d5819e" xlink:to="loc_us-gaap_SubsequentEventMember_12a94de3-1417-4239-8ec1-e1e53ba86a6e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_6134a3bc-2a33-4afc-a6e3-841170870d36" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_dd7ead74-0566-496e-8df6-ff86c11924c1" xlink:to="loc_srt_ProductOrServiceAxis_6134a3bc-2a33-4afc-a6e3-841170870d36" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_e0d3b0a6-e094-4064-8e13-8213e3958a4e" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_6134a3bc-2a33-4afc-a6e3-841170870d36" xlink:to="loc_srt_ProductsAndServicesDomain_e0d3b0a6-e094-4064-8e13-8213e3958a4e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_DevelopmentAndRegulatoryMilestoneMember_5a7d4275-da84-4538-bf79-ee77406b768a" xlink:href="tars-20220930.xsd#tars_DevelopmentAndRegulatoryMilestoneMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_e0d3b0a6-e094-4064-8e13-8213e3958a4e" xlink:to="loc_tars_DevelopmentAndRegulatoryMilestoneMember_5a7d4275-da84-4538-bf79-ee77406b768a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_e27b3731-9a88-4932-a796-9b6e783192dc" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_dd7ead74-0566-496e-8df6-ff86c11924c1" xlink:to="loc_srt_CounterpartyNameAxis_e27b3731-9a88-4932-a796-9b6e783192dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_fef83167-cc2d-4065-a5db-a945db65b86c" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_e27b3731-9a88-4932-a796-9b6e783192dc" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_fef83167-cc2d-4065-a5db-a945db65b86c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_LianBioMember_f0258948-c6f5-43f4-be74-e4ffe876247e" xlink:href="tars-20220930.xsd#tars_LianBioMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_fef83167-cc2d-4065-a5db-a945db65b86c" xlink:to="loc_tars_LianBioMember_f0258948-c6f5-43f4-be74-e4ffe876247e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_ba927ee7-83f7-4231-8d28-a10ff7e8c432" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_dd7ead74-0566-496e-8df6-ff86c11924c1" xlink:to="loc_us-gaap_TypeOfArrangementAxis_ba927ee7-83f7-4231-8d28-a10ff7e8c432" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_42ce2374-4483-4476-9c6d-37296e2edeaa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_ba927ee7-83f7-4231-8d28-a10ff7e8c432" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_42ce2374-4483-4476-9c6d-37296e2edeaa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementTransactionWithPartyToCollaborativeArrangementMember_180bcbc9-0ace-4374-844c-175f2dd24bd2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollaborativeArrangementTransactionWithPartyToCollaborativeArrangementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_42ce2374-4483-4476-9c6d-37296e2edeaa" xlink:to="loc_us-gaap_CollaborativeArrangementTransactionWithPartyToCollaborativeArrangementMember_180bcbc9-0ace-4374-844c-175f2dd24bd2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventLineItems_3cae45e7-dd2d-4093-ba7d-0aad1a643972" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_dd7ead74-0566-496e-8df6-ff86c11924c1" xlink:to="loc_us-gaap_SubsequentEventLineItems_3cae45e7-dd2d-4093-ba7d-0aad1a643972" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_tars_CollaborativeArrangementMilestonePayment_01afc4cd-fb6e-43e9-bf03-52f96300ae81" xlink:href="tars-20220930.xsd#tars_CollaborativeArrangementMilestonePayment"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_3cae45e7-dd2d-4093-ba7d-0aad1a643972" xlink:to="loc_tars_CollaborativeArrangementMilestonePayment_01afc4cd-fb6e-43e9-bf03-52f96300ae81" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
